Maternal and Pediatric Precision in Therapeutic Knowledge Portal (MPRINT-KP): Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations [0.03%]
母体和儿科精准治疗知识门户(MPRINT-KP): 母体和儿科人群药理学研究现状分析
Xiaofu Liu,Aditi Shendre,Lei Wang et al.
Xiaofu Liu et al.
Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these pop...
Aspirin Deprescribing Interventions for Primary Prevention: A Systematic Review and Proposed Guidance for Deprescribing [0.03%]
初级预防阿司匹林去处方干预措施的系统评价及去处方建议的制定
Alison Lobkovich,Hannah Ferrari,Amber Lanae Martirosov et al.
Alison Lobkovich et al.
Recent literature indicates that the benefits of aspirin use for primary prevention of atherosclerotic cardiovascular disease (ASCVD) may be equivocal to the risk. This has resulted in several organizations making updates to their clinical ...
Probiotic Supplementation as an Adjuvant Therapy in Pediatric Drug-Resistant Epilepsy: A Double-Blind Placebo-Controlled Trial [0.03%]
益生菌作为儿童药物抵抗性癫痫辅助治疗的临床双盲安慰剂对照试验
Amira R Rashdan,Sahar M El-Haggar,Ahmed Mustafa Kishk et al.
Amira R Rashdan et al.
Background: Drug-resistant epilepsy (DRE) is increasingly linked to neuroinflammatory mechanisms driven by gut dysbiosis. These mechanisms compromise blood-brain barrier integrity, enhance seizure susceptibility, and modu...
Randomized Controlled Trial
Pharmacotherapy. 2026 Mar;46(3):e70117. DOI:10.1002/phar.70117 2026
Jennifer N Clements,Julia Mesawich,Cassandra Twisdale
Jennifer N Clements
Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin le...
Oral β-Lactams for Complicated Urinary Tract Infections: A Systematic Review and Point-Counterpoint Comparison With Trimethoprim/Sulfamethoxazole and Fluoroquinolones [0.03%]
用于复杂性尿路感染的口服β-内酰胺类药物：系统评价和与甲氧苄氨嘧啶/磺胺甲噁唑及氟喹诺酮类药物对比分析
Ashlan J Kunz Coyne,Jeannette Bouchard,Spencer H Durham et al.
Ashlan J Kunz Coyne et al.
Background: Rising resistance and toxicity concerns with fluoroquinolones (FQs) and trimethoprim/sulfamethoxazole (TMP/SMX) have prompted interest in oral β-lactams as alternatives for complicated urinary tract infection...
Comparative Study
Pharmacotherapy. 2026 Mar;46(3):e70118. DOI:10.1002/phar.70118 2026
Cohort Study to Determine the Impact of CYP3A5 Genotype on Tacrolimus Dosing Requirements and Trough Concentrations in Heart Transplant Recipients [0.03%]
一项队列研究：CYP3A5基因型对心脏移植受者的他克莫司给药需求和谷浓度的影响
Yanting Wu,Michael T Eadon,Laurie Schenkelberg et al.
Yanting Wu et al.
Background: Tacrolimus is primarily metabolized by Cytochrome P450 (CYP)3A4/5. The Clinical Pharmacogenetics Implementation Consortium recommends increasing the initial dose 1.5- to 2-fold in CYP3A5 expressers to enhance ...
Considerations for Menstrual Suppression in Patients With Hematologic Malignancies [0.03%]
血液系统恶性肿瘤患者月经抑制的考虑因素
Sahaana Veeravalli,Allison Schepers,Lydia L Benitez et al.
Sahaana Veeravalli et al.
Patients who menstruate during treatment for hematologic malignancies have a higher risk of heavy vaginal bleeding due to thrombocytopenia caused by malignancy and myelosuppressive chemotherapy. Heavy menstrual bleeding is associated with s...
Immune Checkpoint Inhibitor Exposure During Pregnancy: A Systematic Review [0.03%]
妊娠期间接触免疫检查点抑制剂：系统性回顾
Casey L Keller,Kristina C Hermanson,Ryan M Schuller et al.
Casey L Keller et al.
Immune checkpoint inhibitors (ICIs) have been widely implemented in current oncology practice. However, there is limited data regarding ICI administration in pregnancy. This systematic review aims to evaluate the risk-benefit of ICI exposur...
Development and Validation of a Time-Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug-Resistant Tuberculosis [0.03%]
耐药性肺结核患者使用利奈唑胺治疗期间预测血液学毒性的时变列线图的开发和验证
Wenqiang Zhou,Hui Zhu,Zhongquan Liu et al.
Wenqiang Zhou et al.
Background: Linezolid is essential for drug-resistant tuberculosis (DR-TB) treatment but causes frequent hematological toxicity. We developed a time-dependent nomogram to predict this risk. ...
Association of Serotonin Transporter Gene 5HTTLPR rs25531 Polymorphism With Escitalopram Efficacy in Patients With Major Depressive Disorder [0.03%]
五羟色胺转运体基因多态性与艾斯西酞普兰治疗抑郁症疗效的关系研究
Muhammad Faisal Afridi,Shahbaz Ahmad Zakki,Rafiullah Rafiullah et al.
Muhammad Faisal Afridi et al.
Background: Escitalopram is considered a cornerstone therapy for major depression, but inter-individual variations exist in its clinical efficacy. The current study aims to explore the possible association between seroton...
Observational Study
Pharmacotherapy. 2026 Feb;46(2):e70098. DOI:10.1002/phar.70098 2026