Quantifying the Serum Magnesium Response and Predictors of Response Following Intravenous Magnesium Replacement in Critically Ill Patients [0.03%]
危重症患者静脉补镁治疗的血镁反应及影响因素分析定量研究
Naheel Said,Giovani Angelotti,Wedad Awad et al.
Naheel Said et al.
Background and objective: Intravenous magnesium is commonly used in critically ill patients; however, data on the serum level response following its administration are limited. This study aimed to evaluate serum magnesium...
Multicenter Study
Pharmacotherapy. 2026 Jul;46(7):e70175. DOI:10.1002/phar.70175 2026
Cost-Effectiveness Analysis of Patient Self-Management of Warfarin Among Patients With Non-Valvular Atrial Fibrillation [0.03%]
非瓣膜性房颤患者华法林自管理的成本效益分析
Warittakorn Kategeaw,Daniel M Witt,Jordan B King et al.
Warittakorn Kategeaw et al.
Background: Patient self-management (PSM) is a warfarin management strategy that allows patients to independently adjust their doses. PSM significantly reduces thrombosis events and has been widely implemented internation...
Factors That Influence Blood Pressure Changes With the Use of Sodium-Glucose Cotransporter 2 Inhibitors in People With Type 2 Diabetes [0.03%]
影响钠-葡萄糖共转运体2抑制剂使用对2型糖尿病患者血压变化的因素
Sara Salama,Charlotte Bolch,Dejan Landup et al.
Sara Salama et al.
Study objective: Multiple clinical trials have reported variable reductions in blood pressure with sodium-glucose cotransporter 2 (SGLT2) inhibitors. Given the variability in the magnitude of blood pressure reduction obse...
Multicenter Study
Pharmacotherapy. 2026 Jun;46(6):e70156. DOI:10.1002/phar.70156 2026
Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis [0.03%]
重症脓毒症患者静脉推注希刻劳的药代动力学分析
Susan E Smith,Rehana Bagodiya,Phuong Luong et al.
Susan E Smith et al.
Background: Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited,...
Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report [0.03%]
持续皮下注射氯胺酮可能会诱导他克莫司和西罗莫司的清除：一例报告
Jana Stojanova,Bridin Murnion,Fay Burrows et al.
Jana Stojanova et al.
Background: Drug interactions involving immunosuppressants can compromise transplant outcomes. Although repeated ketamine administration induces hepatic enzymes in experimental models, clinical reports of induced clearanc...
Case Reports
Pharmacotherapy. 2026 Jun;46(6):e70150. DOI:10.1002/phar.70150 2026
Hyperfiltration in Critically Ill Older Adults: Incidence, Risk Factors, Time Course, and Predictive Performance of Kidney Function Estimation [0.03%]
危重症老年患者的高滤过率：发病率、风险因素、时间过程及肾功能估计的预测性能
Ryusei Mikami,Shungo Imai,Mineji Hayakawa et al.
Ryusei Mikami et al.
Study objective: This study aimed to evaluate the incidence, associated risk factors, time course, and predictive performance of kidney function estimation equations for hyperfiltration in critically ill older adults. ...
Observational Study
Pharmacotherapy. 2026 Jun;46(6):e70153. DOI:10.1002/phar.70153 2026
Seonga Song,Lilia Davenport,Samantha Paone et al.
Seonga Song et al.
Oncofertility is the practice of joining oncology clinicians with reproductive endocrinologists to assess patients' tumor biology, tumor stage, and mutation analysis to discuss the infertility risks from tumor-directed treatments and provid...
Predictors and Clinical Outcomes of Long-Term Opioid Therapy in Older Adults: A Systematic Review [0.03%]
老年人长期接受阿片类药物治疗的预测因素和临床结局：系统性回顾
Iftekhar Ahmed,Nina E Teo,Noha Keshk et al.
Iftekhar Ahmed et al.
Introduction: Older adults have a higher prevalence of pain and are more likely to receive long-term opioid therapy (LTOT) compared to other age groups. They are also at elevated risk of opioid-related adverse events due ...
Bayesian Dosing Simulator (BDS): A Pharmacokinetic Modeling Tool for Optimized Antibiotic Therapy [0.03%]
基于贝叶斯法的抗生素个体化剂量计算软件包及其模拟程序开发与应用研究
Adrian Valadez,Marc H Scheetz,Michael N Neely et al.
Adrian Valadez et al.
Background: Meropenem is widely used to treat hospital-acquired pneumonia in critically ill patients, with efficacy dependent on the time that free concentrations exceed the minimum inhibitory concentration (fT > MIC). In...