A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Zomepirac Sodium, Aspirin, and Placebo in Postoperative Oral Surgery Pain [0.03%]
术后拔牙后的 diflunisal，zomepirac 钠盐，阿斯匹林及安慰剂的 12 小时止痛效果评估研究
James A Forbes,Geraldine A Butterworth,William H Burchfield et al.
James A Forbes et al.
One hundred ninety-nine outpatients with pain following oral surgery were randomly assigned, on a double-blind basis, a single oral dose of diflunisal (500 or 1,000 mg), zomepirac sodium 100 mg, aspirin 650 mg, or placebo. Using a self-rati...
A Method for the 12-Hour Evaluation of Analgesic Efficacy in Outpatients with Postoperative Oral Surgery Pain: Three Studies of Diflunisal [0.03%]
一项有关口服手术术后镇痛药疗效的12小时评价方法：二氟尼柳三项研究汇总报告
William T Beaver,James A Forbes,Robert W Shackleford
William T Beaver
We have developed a method for measuring the efficacy of a single dose of an analgesic for 12 hours after administration to outpatients with postoperative oral surgery pain. Using a self-rating record, patients evaluate their pain and its r...
T Y Shen
T Y Shen
Diflunisal, 5-(2',4'-difluorophenyl) salicylic acid, was discovered as a potent antiinflammatory analgesic agent after an extensive investigation of more than 500 salicylic acid analogs. The addition of a difluorophenyl substituent at the C...
A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Acetaminophen, an Acetaminophen-Codeine Combination, and Placebo in Postoperative Pain [0.03%]
术後疼痛的消炎痛、醋氨酚及其与可卡因合用制剂和无效剂疗效的12小时评价
James A Forbes,A Lewis Kolodny,William T Beaver et al.
James A Forbes et al.
The analgesic efficacy of single 500 and 1,000 mg doses of diflunisal, a new nonsteroidal antiinflammatory analgesic, was compared in a double-blind study with acetaminophen 600 mg, the combination of acetaminophen 600 mg with codeine 60 mg...
Effects of Diflunisal on Platelet Function and Fecal Blood Loss [0.03%]
对水杨酸类药物 diflunisal 血小板功能和粪便出血影响的实验研究
David Green,Richard O Davies,Geoffrey I Holmes et al.
David Green et al.
The effects of diflunisal, a nonacetylated difluorinated salicylate, on platelet function were compared with those of aspirin and placebo. In a randomized, double-blind trial, normal subjects were given diflunisal, 250, 500, or 1,000 mg twi...
J Alfred Rider
J Alfred Rider
Diflunisal 1,000 mg/day, aspirin 4.0 g/day, or placebo were given to 36 healthy volunteers for 14 days to determine fecal blood loss. There was a significant increase in fecal blood loss from baseline in the aspirin group compared to both t...
Diflunisal in the Treatment of the Pain of Osteoarthritis Summary of Clinical Studies [0.03%]
diflunisal治疗骨关节炎疼痛的临床研究概况
Elmer R Umbenhauer
Elmer R Umbenhauer
In comprehensive clinical studies, diflunisal - a new nonsteroidal antiinflammatory drug with a long duration of action - was shown to be highly effective and generally well tolerated in the short- and long-term treatment of the pain of ost...
Strength in Amalgamation: Newer Combination Agents for HIV and Implications for Practice [0.03%]
联合抗艾滋病病毒药物的新进展及临床应用展望
Christopher McCoy,Melissa Badowski,Elizabeth Sherman et al.
Christopher McCoy et al.
Antiretroviral (ART) therapy for the treatment of human immunodeficiency virus (HIV) infection has undergone significant changes over the past 30 years. Many single-tablet regimens (STRs), including newer fixed-dose combination (FDC) tablet...
Impact of Penicillin Allergy on Empirical Carbapenem Use in Gram-Negative Bloodstream Infections: An Antimicrobial Stewardship Opportunity [0.03%]
青霉素过敏对革兰氏阴性败血症经验性使用碳青霉烯类药物的影响：抗菌管理中的一个机会点
Majdi N Al-Hasan,Emily C Acker,Joseph E Kohn et al.
Majdi N Al-Hasan et al.
Objectives: Retrospective matched-cohort study evaluating association between penicillin allergy and empirical carbapenem use in gram-negative bloodstream infections (BSIs) and utility of antimicrobial stewardship interve...
Incidence of and Risk Factors for Severe Adverse Events in Elderly Patients Taking Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers after an Acute Myocardial Infarction [0.03%]
老年患者急性心肌梗死后使用血管紧张素转换酶抑制剂或血管紧张素II受体阻滞剂发生严重不良事件的发病情况及危险因素分析
Gang Fang,Izabela E Annis,Joel F Farley et al.
Gang Fang et al.
Study objective: To assess the incidence of and risk factors associated with severe adverse events in elderly patients who used angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) a...