Evolving Role of Non-Statin Therapy for the Management of Dyslipidemia and Cardiovascular Risk Reduction: Past, Present, and Future [0.03%]
胆固醇管理：从过往到未来非他汀疗法在脂质异常和心血管风险降低中的作用日益重要
Evan M Sisson,Lauren Pamulapati,John D Bucheit et al.
Evan M Sisson et al.
PARADIGM-HF Trial: Secondary Analyses Address Unanswered Questions [0.03%]
PARADIGM-HF研究：回答未解决问题的二次分析
Kristin R Smith,Chia-Chi Hsu,Theodore J Berei et al.
Kristin R Smith et al.
Our aim was to summarize published secondary analyses of the PARADIGM-HF trial. In the original trial, published in September 2014, sacubitril/valsartan significantly reduced the primary composite outcome of cardiovascular death or heart fa...
Nieves Gómez-Coronado,Adam J Walker,Michael Berk et al.
Nieves Gómez-Coronado et al.
Tobacco use disorder is a chronic illness. With its high comorbidity rate, it is a major cause of years of life lost or years lived with disability; however, it is also considered the most preventable cause of death in developed countries. ...
Evaluation of the Use of Novel Biomarkers to Augment Antimicrobial Stewardship Program Activities [0.03%]
评估使用新型生物标志物增强抗菌药物管理计划活动的效果
Kayla R Stover,Rachel M Kenney,Samuel Travis King et al.
Kayla R Stover et al.
As antimicrobial stewardship increasingly receives worldwide attention for improving patient care by optimizing antimicrobial therapy, programs are evaluating new tools that may augment antimicrobial stewardship activities. Biomarkers are o...
Melissa E Badowski,Scot Walker,Shaffeeulah Bacchus et al.
Melissa E Badowski et al.
The goal of this white paper is to provide direction for clinical pharmacists providing telehealth. Telehealth care is rapidly emerging to improve patient access to health care and optimize patient health outcomes. With the increasing abili...
Navaneeth Narayanan,Clifton R Lacy,Joseph E Cruz et al.
Navaneeth Narayanan et al.
Biological disasters can be natural, accidental, or intentional. Biological threats have made a lasting impact on civilization. This review focuses on agents of clinical significance, bioterrorism, and national security, specifically Catego...
Association of Higher Daptomycin Dose (7 mg/kg or Greater) with Improved Survival in Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia [0.03%]
达托霉素剂量(≥7 mg/kg)与甲氧西林耐药金黄色葡萄球菌血流感染患者生存改善的关系
Tristan T Timbrook,Aisling R Caffrey,Megan K Luther et al.
Tristan T Timbrook et al.
Study objective: Current guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this reco...
Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease [0.03%]
用于改变炎性肠病患者硫嘌呤代谢以优化治疗的别嘌呤醇添加疗法
Geoffrey C Wall,Hamid Muktar,Cassandra Effken et al.
Geoffrey C Wall et al.
Thiopurine drugs, including azathioprine and 6-mercaptopurine, are used commonly in patients with inflammatory bowel disease for maintenance of remission. Although generally well tolerated, adverse effects lead to discontinuation in a signi...
Refining a Claims-based Algorithm to Estimate Biologic Medication Effectiveness and Cost per Effectively Treated Patient with Rheumatoid Arthritis [0.03%]
改进基于索赔的算法以估计生物制剂在治疗类风湿关节炎患者中的有效性和每位患者的治疗成本
Ryan A Popp,Karen Rascati,Matthew Davis et al.
Ryan A Popp et al.
Background: Claims data generally lack information on clinical outcomes. However, a validated claims-based algorithm for estimating the effectiveness of biologic agents in treating rheumatoid arthritis (RA) was recently d...
Ketamine Infusion for Adjunct Sedation in Mechanically Ventilated Adults [0.03%]
用于机械通气成人患者辅助镇静的氯胺酮输注疗法
Lara M Groetzinger,Ryan M Rivosecchi,William Bain et al.
Lara M Groetzinger et al.
Background: Many critically ill patients receive ketamine for adjunct sedation despite a paucity of evidence on its use, dosing, and monitoring in this setting. ...