Trends in Initiation of Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis Among Commercially Insured Adults in the United States, 2001-2021 [0.03%]
2001至2021年美国商业保险成人启动类风湿关节炎疾病修饰抗风湿药物的趋势
Lydia Y Lee,Jeffrey A Sparks,Priyanka Yalamanchili et al.
Lydia Y Lee et al.
Objective: To evaluate patterns in disease-modifying antirheumatic drugs (DMARDs) initiations between 2001 and 2021 among adults with Rheumatoid Arthritis (RA) in the United States METHODS: This retrospective cohort study...
Hereditary Pseudocholinesterase Deficiency and Succinylcholine: Historical Perspective, Therapeutic Implications, and Future Considerations [0.03%]
遗传性假胆碱酯酶缺乏症与司可林：历史回顾、治疗意义及未来考虑事项
Jenny Q Nguyen,Courtney Paetznick,Roseann S Donnelly
Jenny Q Nguyen
Succinylcholine, a commonly used neuromuscular blocker, is hydrolyzed by the pseudocholinesterase (also known as butyrylcholinesterase) enzyme in the plasma to inactive metabolites. Individuals who have inherited genetic variants in the BCH...
Biological Therapy and Small Molecules for Adults With Crohn's Disease: Systematic Review and Network Meta-Analysis [0.03%]
成人克罗恩病生物制剂和小分子药物治疗的系统评价和网络 meta 分析
Daniela Gorski,Raul Edison Luna Lazo,Dalton de Assis de Souza et al.
Daniela Gorski et al.
First-line therapeutic approaches for Crohn's disease include immunosuppressants, aminosalicylates, and corticosteroids. However, more than one-third of patients are resistant to these treatments and require second-line therapies. Our goal ...
Comment on "Proton Pump Inhibitor Concomitant Use to Prevent Oxaliplatin-Induced Peripheral Neuropathy: Clinical Retrospective Cohort Study" [0.03%]
关于“质子泵抑制剂联用预防奥沙利铂外周神经毒性：临床回顾性队列研究”的述评
Majid Khalilizad,Ebrahim Hejazian,Mohammad Barary et al.
Majid Khalilizad et al.
Response to Comment on "Proton Pump Inhibitor Concomitant Use to Prevent Oxaliplatin-Induced Peripheral Neuropathy: Clinical Retrospective Cohort Study" [0.03%]
奥沙利铂诱导的外周神经病变预防性联合使用质子泵抑制剂：临床回顾队列研究——评论及回复
Keisuke Mine,Takehiro Kawashiri,Yusuke Mori et al.
Keisuke Mine et al.
Precision Daptomycin Dosing: Comparison of 3-, 2-, 1-, and 0-Concentration Sample Strategies [0.03%]
达托霉素精准给药：比较3、2、1和0个浓度样本策略的效果
Simone Giuliano,Manjunath P Pai,Jacopo Angelini et al.
Simone Giuliano et al.
Background: Daptomycin is a once-daily lipopeptide antibiotic with a narrow therapeutic window. As higher doses (8-12 mg/kg) are increasingly used to treat resistant gram-positive infections, achieving therapeutic exposur...
Genome-wide associations with metabolic syndrome among UK Biobank participants reporting use of second-generation antipsychotics [0.03%]
在使用第二代抗精神病药物的英国生物银行参与者中与代谢综合征的全基因组关联分析
Nihal El Rouby,Aniwaa Owusu-Obeng,Michael Preuss et al.
Nihal El Rouby et al.
Objectives: Second-generation antipsychotic (SGA) medications are frequently prescribed for mental health conditions; however, they are associated with an increased risk of metabolic syndrome (MetS). We aimed to identify ...
Effect of P2Y12 Inhibitors on Major Adverse Cardiovascular Events After Coronary Artery Bypass Graft Surgery: A Population-Based Cohort Study [0.03%]
冠脉旁路移植术后血小板P2Y12受体抑制剂与主要心血管不良事件的关联：基于人群的队列研究
Arden R Barry,Hamed Helisaz,Abdollah Safari et al.
Arden R Barry et al.
Background: Patients who undergo coronary artery bypass graft (CABG) surgery remain at high risk for major adverse cardiovascular events (MACE) despite contemporary preventive pharmacotherapy. Although commonly used in pr...
A Large Cohort Study to Identify Risk Factors of Acute Kidney Injury in Pediatric Patients Undergoing Intravenous Vancomycin Therapy [0.03%]
一项大型队列研究：识别静脉给药万古霉素治疗儿科患者急性肾损伤的风险因素
Rahul K Goyal,Brady S Moffett,Kristine A Parbuoni et al.
Rahul K Goyal et al.
Background and objectives: The relative contribution of vancomycin exposure versus clinical factors to acute kidney injury (AKI) development in pediatric patients remains unclear. This study examined risk factors for AKI ...
Intraperitoneal Granisetron for Post-Laparoscopic Cholecystectomy Pain Management: A Double-Blinded, Randomized Controlled Trial [0.03%]
腹腔内注射格拉司琼用于 laparoscopy胆囊切除术 术后镇痛的双盲随机对照研究
Hoda Mohamed Bayoumi,Doaa Hamed Abdelaziz,Sherif Boraii et al.
Hoda Mohamed Bayoumi et al.
Background: Laparoscopic cholecystectomy (LC) may cause significant pain, increasing morbidity. Granisetron, an antiemetic selective serotonin (5HT3)-antagonist, demonstrates analgesic properties through sodium channel bl...