Focusing on an EEG Biomarker, the Photoparoxysmal Response (PPR), to Identify Promising Investigational Anti-Seizure Medications (ASMs) and Differentiate the Efficacy of Existing ASMs [0.03%]
通过聚焦EEG生物标志物光诱发反应（PPR）来识别有前景的试验性抗癫痫药物（ASM）并区分现有ASM的有效性
Ronald C Reed,Dorothee G A Kasteleijn-Nolst Trenite
Ronald C Reed
Lithium Augmentation in Treatment-Resistant Depression: A Qualitative Review of the Literature [0.03%]
难治性抑郁障碍的锂增效治疗：文献定性综述
Angela Acero-González,Yahira Guzman,Nadia Juliana Proaños et al.
Angela Acero-González et al.
Depression is the leading cause of disability worldwide, affecting people of all ages. Both pharmacological and non-pharmacological therapies are available for its treatment. However, some patients do not respond to first-line pharmacologic...
Synthetic Data-Driven Early Prediction Framework for Acute Kidney Injury in Patients Receiving Vancomycin and Ceftazidime/Avibactam [0.03%]
基于合成数据的万古霉素和头孢他啶/阿维巴坦用药患者的急性肾损伤早期预测框架
Maryam Ramazani,Todd Brothers,Imtiaz Ahmed et al.
Maryam Ramazani et al.
Background: The nephrotoxic risks of combining ceftazidime/avibactam (AVI) with vancomycin (VAN) remain underexplored, despite both agents independently being linked to acute kidney injury (AKI). This study assessed the r...
Association of Omeprazole-Related Myopathy With Drug-Drug and Drug-Gene Interactions Involving CYP2C19 and CYP3A4: A Nested Case-Control Study [0.03%]
含CYP2C19和CYP3A4药物-药物及药物-基因相互作用的奥美拉唑相关性肌病的病例对照研究
Eugene Jeong,Aditi Shendre,Yu Su et al.
Eugene Jeong et al.
Background: Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a pote...
Bradley J Peters,Luz Y Sullivan,Rebecca L Lange et al.
Bradley J Peters et al.
We describe a case of a 56-year-old male who developed severe, refractory hypotension after an intentional ingestion of clozapine and who became hemodynamically stable after one session of therapeutic plasma exchange (TPE). The patient, who...
Case Reports
Pharmacotherapy. 2025 Sep 7. DOI:10.1002/phar.70057 2025
Severe Persistent Urinary Retention Following Treatment With Intravenous Lecanemab: Urinary Retention With IV Lecanemab [0.03%]
仑伐单抗静脉给药后的严重持续性尿潴留：仑伐单抗静脉给药所致的尿潴留
Amber N Navarra,Laura A Wang,Heba Al-Sahlani et al.
Amber N Navarra et al.
Lecanemab is an amyloid-targeted antibody indicated for treating patients with amyloid-confirmed early Alzheimer's Disease in mild dementia or mild cognitive impairment stages. We report here a case of a subject with early stage of Alzheime...
Case Reports
Pharmacotherapy. 2025 Sep 5. DOI:10.1002/phar.70060 2025
A Multicenter, Open-Label Study to Assess the Safety of Nebulized Tissue Plasminogen Activator for the Acute Treatment of Pediatric Plastic Bronchitis: The PLATyPuS Trial [0.03%]
评价用于急性治疗儿童塑形性支气管炎的雾化组织型纤溶酶原激活剂的安全性的多中心开放标签研究：PLATyPuS试验
Kathleen A Stringer,David Goldberg,Sharon Chen et al.
Kathleen A Stringer et al.
Introduction: Pediatric plastic bronchitis (PB) is a rare complication of surgically palliated congenital heart disease (CHD). Fibrin casts obstruct airways and can cause respiratory distress. There are no therapeutics ap...
Restarting Oral Anticoagulation in Patients With Atrial Fibrillation After Admission for a Gastrointestinal Bleeding Event: Effectiveness and Safety of Direct Oral Anticoagulants Compared to Warfarin [0.03%]
非瓣膜性房颤患者因上消化道出血住院后的抗凝治疗：直接口服抗凝药与华法林的有效性和安全性比较
Oluwadolapo D Lawal,Herbert D Aronow,Fisayomi Shobayo et al.
Oluwadolapo D Lawal et al.
Background: There are sparse data to guide resumption of direct oral anticoagulants (DOACs) versus warfarin in patients with atrial fibrillation (AF) who survive a major gastrointestinal bleeding (GIB) event. ...
Correction to Chloride Dipstick to Rapidly Estimate Urine Sodium During Diuresis in Acute Heart Failure [0.03%]
纠正氯化物试纸快速估计急性心力衰竭利尿期间尿钠的方法
V. Shah, D. Cordwin, S. L. Hummel, M. P. Dorsch, "Chloride Dipstick to Rapidly Estimate Urine Sodium During Diuresis in Acute Heart Failure." Pharmacotherapy. 45, (2025): 352-355. https://doi.org/10.1002/phar.70026. The author's name, V Sha...
Published Erratum
Pharmacotherapy. 2025 Aug 13. DOI:10.1002/phar.70052 2025
Drug-Drug Interactions and Combination Therapy Strategies of Amiodarone With Digoxin, Rivaroxaban, and Phenytoin Assessed by Physiologically Based Pharmacokinetic Modeling [0.03%]
基于生理的药代动力学模型评估胺碘酮与地高辛、利伐沙班和苯妥英相互作用及联合用药策略的研究
Youjun Chen,Zhiwei Liu,Yiming Li et al.
Youjun Chen et al.
Background: Amiodarone (AMI) is a potent inhibitor of Cytochrome P450 (CYP) 2C9 and P-glycoprotein (P-gp), as well as a weak inhibitor of CYP3A4. Concomitant administration of AMI with digoxin (DIG), rivaroxaban (RIV), or...