Utilizing Machine Learning to Identify Predictors of Corticosteroid Discontinuation 1-Year After Adult Heart Transplant [0.03%]
机器学习识别成人心脏移植术后一年皮质类固醇减停预测因素
Caroline Chen,Zeina Jedeon,Abhishek Jaiswal et al.
Caroline Chen et al.
Objective: To use machine learning methods to identify factors associated with corticosteroid (CS) discontinuation 1 year after adult heart transplantation (HT). ...
Impact of Gabapentin as a Benzodiazepine-Sparing Medication During Acute Alcohol Withdrawal [0.03%]
加巴喷丁作为急性酒精戒断期苯二氮卓类药物的替代品的效果研究
William G Cordell,Leah A Surbaugh,Kelsey Inman et al.
William G Cordell et al.
Background: Abrupt cessation of alcohol consumption after prolonged periods of use leaves patients at risk for experiencing withdrawal symptoms. Alcohol is a central nervous system depressant that increases the activity o...
Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Partial- and Full-Thickness Skin Burns [0.03%]
塞铂拉霉素/他唑巴坦在部分和全部皮肤厚度烧伤患者中的药动学特征
Ronald G Hall nd,Levi Hooper,Sharmila Dissanaike et al.
Ronald G Hall nd et al.
Introduction: Patients with burns are at an increased risk of multidrug-resistant pathogens including Pseudomonas aeruginosa and may need specialized dosing regimens due to alterations in physiology due to their injuries....
Developing New Drugs for the COVID-19 Emergency: Anatomy of the U.S. Response [0.03%]
美国对新冠肺炎疫情的药物研发响应及其启示
Thomas J Moore,Mariana P Socal,Gerard Anderson
Thomas J Moore
Context: To meet the need for effective treatments during the COVID-19 Public Health Emergency, the U.S. government sought to accelerate the discovery and development of new antiviral treatments-a process that normally to...
High-Throughput Screening for Prescribing Cascades Among Real-World Angiotensin-II Receptor Blockers (ARBs) Initiators [0.03%]
高效筛选现实生活中的血管紧张素II受体阻滞剂使用者处方变化的案例
Asinamai M Ndai,Kayla Smith,Shailina Keshwani et al.
Asinamai M Ndai et al.
Objective: Angiotensin-II Receptor Blockers (ARBs) are commonly prescribed; however, their adverse events may prompt new drug prescriptions, known as prescribing cascade (PC). We aimed to identify potential ARB-induced PC...
C Lindsay DeVane
C Lindsay DeVane
Identifying Pediatric Drug Safety Knowledge Gaps: An Integrated Approach Leveraging Real-World Data, a Biomedical Knowledge Base, and Postmarketing Surveillance Data [0.03%]
利用真实世界数据、生物医学知识库和上市后监测数据识别儿科药物安全性知识缺口的综合方法
Saurabh Rahurkar,Jiayi Ouyang,Pallavi Jonnalagadda et al.
Saurabh Rahurkar et al.
Background: Drug safety has historically been understudied in pediatric populations, rendering them "therapeutic orphans." Pediatric drug indications and dosages are often inferred by extrapolating safety, efficacy, and d...
Acute Pharmacodynamic Effects of Oral Levodopa on Blood Pressure in Parkinson's Disease [0.03%]
口服左旋多巴对帕金森病患者血压急性药理学效应的影响
Katherine Longardner,Cat Liu,Jeremiah Momper et al.
Katherine Longardner et al.
Background: Levodopa decreases blood pressure (BP) in persons with Parkinson's disease (PwP), but no pharmacodynamic studies integrating systemic levodopa concentration measurements have characterized its hypotensive effe...
Nephrocast-V: A Deep Learning Model for the Prediction of Vancomycin Trough Concentration Using Electronic Health Record Data [0.03%]
基于电子健康记录数据的万古霉素谷浓度预测深度学习模型:Nephrocast-V
Ghodsieh Ghanbari,Craig Stevens,Eliah Aronoff-Spencer et al.
Ghodsieh Ghanbari et al.
Introduction: Vancomycin is a critical antibiotic for treating methicillin-resistant Staphylococcus aureus and other gram-positive bacterial infections, but achieving and maintaining therapeutic trough concentrations is c...