Intravenous Push Levetiracetam Administration Compared With Intravenous Piggyback on Benzodiazepine Use for Acute Seizure Treatment [0.03%]
静脉注射左乙拉西坦与静脉附带注射对苯二氮卓急性 seizure 治疗使用情况的比较研究
Sarah C Markovich,Justin Miller,Rebecca Lucarelli et al.
Sarah C Markovich et al.
Introduction: Levetiracetam (LEV) is indicated for benzodiazepine (BZD) refractory status epilepticus (SE) and is traditionally administered as an intravenous piggyback (IVPB) infused over 15 min, although rapid intraveno...
Correction to "Relationship of the Revised Anticholinergic Drug Scale With Cultured Cell-Based Serum Anticholinergic Activity and Cognitive Measures in Older Adults With Mild Cognitive Impairment or Remitted Depression" [0.03%]
关于“修订后的抗胆碱药量表与老年轻度认知障碍或抑郁缓解期患者体外细胞培养基抗胆碱活性和认知测量的关系”的勘误
Published Erratum
Pharmacotherapy. 2025 Nov 25. DOI:10.1002/phar.70077 2025
Predicting Pharmacological Treatment Response in Migraine Using AI/ML: A Scoping Review of the Evidence and Future Directions [0.03%]
利用人工智能/机器学习预测偏头痛药物治疗反应的证据及未来方向的综述研究
Martina Giacon,Salvatore Terrazzino
Martina Giacon
The treatment of migraine is hampered by inter-individual variability, leading to an inefficient "trial and error" approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therap...
Intravenous Regular Insulin for Treatment of Hyperkalemia in Overweight Patients [0.03%]
overweight患者治疗高钾血症的静脉注射常规胰岛素疗法
Denise Kelley,Sarah Piccuirro,Prakruti Gandhi et al.
Denise Kelley et al.
Introduction: Intravenous regular insulin is often used for the management of hyperkalemia due to its rapid onset of action and predictable potassium-lowering effects. Various studies have been conducted to determine opti...
Correlation Between Analgesic and Sedative Drug Withdrawal and Salivary Cortisol Levels in Children in PICUs: A Prospective Cohort Study [0.03%]
儿童PICU镇痛和镇静药物撤药与唾液皮质醇水平的相关性：一项前瞻性队列研究
Yaping Zhan,Shu Lin,Lingjie Lin et al.
Yaping Zhan et al.
Background and objective: Opioids and benzodiazepines are the most widely utilized sedative-analgesic agents in pediatric intensive care units (PICUs). However, prolonged exposure to these drugs may lead to drug tolerance...
Prescription Sequence Symmetry Analysis for Detection of Chronic Opioid Use Adverse Event Signals Using Administrative Claims Data [0.03%]
基于行政收费数据的处方序列对称性分析以发现慢性阿片类药物使用不良事件信号
Efstathia Polychronopoulou,Mukaila A Raji,Yong-Fang Kuo
Efstathia Polychronopoulou
Introduction: Opioids are commonly used to manage chronic pain in older adults, despite their well-documented adverse events (AEs) and the potential for additional less well-known risks. Post-marketing surveillance method...
External Validation of the Fraser Equation for Estimation of Free Valproate Concentrations in Critically Ill Adults [0.03%]
弗雷泽方程在外伤危重成人中估计丙戊酸钠血药浓度的外部验证研究
Andrew J Webb,Caitlin S Brown,JiTong Liu et al.
Andrew J Webb et al.
Background: Critically ill patients may be overexposed to valproate because altered protein binding leads to a disproportionate free valproate fraction. The Fraser equation was derived and internally validated to estimate...
Thromboembolic Risk of Thrombopoietin Receptor Agonists for Adult Primary Immune Thrombocytopenia: A Systematic Review and Meta-Analysis Integrating Randomized Controlled Trials and Prospective Evidence [0.03%]
促血小板生成素受体激动剂治疗成人原发性免疫性血小板减少症的血栓风险：系统评价和荟萃分析，整合随机对照试验和前瞻性证据
Meng-Fei Dai,Gao-Wei Chong,Wen-Xiu Xin et al.
Meng-Fei Dai et al.
Background: Although randomized controlled trials (RCTs) have established evidence regarding thromboembolic risks of thrombopoietin receptor agonists (TPO-RAs) in immune thrombocytopenia (ITP) during short-term follow-up,...
Oritavancin for Treatment of Osteomyelitis: A Systematic Review and Meta-Analysis of Observational Studies [0.03%]
orisponda治疗骨髓炎的系统评价和 meta 分析
Martin Krsak,David Klimpl,Scott W Mueller et al.
Martin Krsak et al.
Background: Osteomyelitis (OM) is a complex inflammatory bone infection typically requiring prolonged antibiotic therapy. Oritavancin (ORI), a long-acting lipoglycopeptide with activity against biofilm-embedded pathogens,...
Comparison of Subcutaneous Versus Intravenous Filgrastim in Autologous Hematopoietic Stem Cell Transplantation: A Retrospective Study [0.03%]
皮下注射与静脉注射非格司亭在自体造血干细胞移植中的对比研究：一项回顾性研究
Glenn Chang,Jelina Nguyen,Elvis Sampson et al.
Glenn Chang et al.
Purpose: Filgrastim is administered to shorten the duration of chemotherapy-induced neutropenia. Filgrastim can be administered intravenously or subcutaneously, but different routes of administration may result in differe...