C-Reactive Protein and Neutrophil-To-Lymphocyte Ratio: Can They Be Used Interchangeably in Tracking Clozapine-Related Inflammation? [0.03%]
C反应蛋白和中性粒细胞-淋巴细胞比率：能否互换用于追踪氯氮平相关炎症？
Nicoline Bihelek,Chad A Bousman,William G Honer et al.
Nicoline Bihelek et al.
Background: Clozapine initiation often triggers inflammatory responses that can alter metabolism via Cytochrome P450 1A2 (CYP1A2) suppression. Although C-reactive protein (CRP) is the recommended marker, it may be unavail...
Real-World Use of Letermovir and Maribavir for CMV Prophylaxis and Treatment in Solid Organ Transplant Recipients: Clinical Outcomes and Resistance Patterns From a Dual-Center Cohort [0.03%]
器官移植受者中使用莱特莫韦和马利布韦预防和治疗巨细胞病毒感染的临床结局及耐药模式：来自一个双中心队列的研究
Man Ting Xu,Alissa Wright,Allison Mah et al.
Man Ting Xu et al.
Background: Cytomegalovirus (CMV) is a major opportunistic infection in solid organ transplant (SOT) recipients. Although valganciclovir is first-line for CMV treatment, its use may be limited by resistance and myelotoxic...
Multicenter Study
Pharmacotherapy. 2025 Dec;45(12):815-824. DOI:10.1002/phar.70086 2025
Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin [0.03%]
二甲双胍或卡格列净治疗多囊卵巢综合征患者的胆汁酸代谢谱特征分析
Qi Yan,Meili Cai,Nan Wang et al.
Qi Yan et al.
Objective: Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combine...
Assessment of Artificial Intelligence (AI)-Powered Self-Care Recommendations for Management of Minor Ailments: A Comparative Analysis [0.03%]
人工智能(AI)驱动的自我护理建议在管理小病小痛方面的评估：比较分析
Sham ZainAlAbdin,Saba Kendakji,Fatema Alrahbi et al.
Sham ZainAlAbdin et al.
Introduction: Self-care and self-medication are increasingly viewed as helpful approaches to managing minor ailments; however, patients are often not confident in making informed choices. Pharmacists have traditionally as...
Therapeutic Modulation of IL-6/STAT-3 and Nitric Oxide by Fenofibrate in Patients With Ulcerative Colitis: A Randomized Controlled Pilot Study [0.03%]
非诺贝特在溃疡性结肠炎患者中的治疗作用：对IL-6/STAT-3和一氧化氮的调节作用的一项随机对照试点研究
Khlood Mohammad Aldossary,Mahmoud S Abdallah,Noha Kamal et al.
Khlood Mohammad Aldossary et al.
Background: Peroxisome proliferator-activated receptor α (PPARα) has been reported to exert protective roles in immune-mediated intestinal diseases through inhibition of interleukin-6 (IL-6)-induced signal transducer an...
Developing a Statistical Modeling-Based Machine Learning Approach for Capturing Drug Dosing Using a Proton Pump Inhibitor Case [0.03%]
基于统计模型的机器学习方法在质子泵抑制剂给药剂量捕获中的应用及建模研究
Amanda Massmann,Jordan F Baye,Max Weaver
Amanda Massmann
Objective: To develop a statistical model to capture medication dosing for proton pump inhibitors (PPIs) using structured data from electronic health records (EHR). ...
Terlipressin Administration Strategies in Hepatorenal Syndrome-Acute Kidney Injury: A Narrative Review of Continuous Infusion and Intermittent Bolus Approaches [0.03%]
肝肾综合征-急性肾损伤的特利加压素连续输注与间歇推注给药策略：综述性文献回顾
Tien Q Pham,Stephanie N Bass,Jason R Yerke
Tien Q Pham
Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of cirrhosis, marked by profound splanchnic vasodilation leading to renal hypoperfusion. Guidelines throughout the years have refined the definitions, cla...
Constructing a Personalized Treatment Rule for Initial Therapy in Early Parkinson's Disease [0.03%]
帕金森病初期治疗的个性化用药规则构建
Zachary P Brehm,Ruth B Schneider,Charles S Venuto et al.
Zachary P Brehm et al.
Background: Dopaminergic therapies such as levodopa and dopamine receptor agonists (DRA) improve motor function in people with Parkinson's disease. These therapies are also linked to the advent of motor complications such...
Machine Learning Algorithms for Predicting Injurious Fall Risk Among Older Adults With Depression: A Prognostic Modeling Study [0.03%]
用于预测抑郁老年人受伤跌倒风险的机器学习算法：一种预后模型研究
Grace Hsin-Min Wang,Yao-An Lee,Amie J Goodin et al.
Grace Hsin-Min Wang et al.
Background: Falls and related injuries (FRI) pose a large burden among older adults with depression. Proactively identifying individuals at high FRI risk enables timely and tailored interventions, reducing unnecessary hea...