Considerations for Menstrual Suppression in Patients With Hematologic Malignancies [0.03%]
血液系统恶性肿瘤患者月经抑制的考虑因素
Sahaana Veeravalli,Allison Schepers,Lydia L Benitez et al.
Sahaana Veeravalli et al.
Patients who menstruate during treatment for hematologic malignancies have a higher risk of heavy vaginal bleeding due to thrombocytopenia caused by malignancy and myelosuppressive chemotherapy. Heavy menstrual bleeding is associated with s...
Immune Checkpoint Inhibitor Exposure During Pregnancy: A Systematic Review [0.03%]
妊娠期间接触免疫检查点抑制剂：系统性回顾
Casey L Keller,Kristina C Hermanson,Ryan M Schuller et al.
Casey L Keller et al.
Immune checkpoint inhibitors (ICIs) have been widely implemented in current oncology practice. However, there is limited data regarding ICI administration in pregnancy. This systematic review aims to evaluate the risk-benefit of ICI exposur...
Development and Validation of a Time-Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug-Resistant Tuberculosis [0.03%]
耐药性肺结核患者使用利奈唑胺治疗期间预测血液学毒性的时变列线图的开发和验证
Wenqiang Zhou,Hui Zhu,Zhongquan Liu et al.
Wenqiang Zhou et al.
Background: Linezolid is essential for drug-resistant tuberculosis (DR-TB) treatment but causes frequent hematological toxicity. We developed a time-dependent nomogram to predict this risk. ...
Association of Serotonin Transporter Gene 5HTTLPR rs25531 Polymorphism With Escitalopram Efficacy in Patients With Major Depressive Disorder [0.03%]
五羟色胺转运体基因多态性与艾斯西酞普兰治疗抑郁症疗效的关系研究
Muhammad Faisal Afridi,Shahbaz Ahmad Zakki,Rafiullah Rafiullah et al.
Muhammad Faisal Afridi et al.
Background: Escitalopram is considered a cornerstone therapy for major depression, but inter-individual variations exist in its clinical efficacy. The current study aims to explore the possible association between seroton...
Observational Study
Pharmacotherapy. 2026 Feb;46(2):e70098. DOI:10.1002/phar.70098 2026
Drew A Wells,Zachery Halford,Kori Holman et al.
Drew A Wells et al.
Cancer therapy-induced cardiotoxicity (CTIC) is a significant clinical challenge in an era of rapidly evolving oncologic treatment. This comprehensive narrative review synthesizes evidence from clinical trials, meta-analyses, and guidelines...
Development and Validation of a Novel Scoring Model Integrating Clinical Risk Factors and Pharmacokinetic Parameters to Predict Vancomycin-Induced Nephrotoxicity [0.03%]
一种新的评分模型的开发和验证：整合临床风险因素和药代动力学参数预测万古霉素致肾毒性的研究
Yoshihiko Matsuki,Ken-Ichi Sako,Yutaro Kozima et al.
Yoshihiko Matsuki et al.
Background: Vancomycin (VCM), a first-line treatment option for infections caused by methicillin-resistant Staphylococcus aureus, has been reported to cause nephrotoxicity even within therapeutic concentration ranges. Tra...
Utilization of dd-cfDNA Monitoring to Facilitate Immunosuppression Minimization After Kidney Transplantation in a U.S. Veteran Population [0.03%]
美国退伍军人肾脏移植受者中采用dd-cfDNA监测指导降低免疫抑制剂量的研究
Laura Cotiguala,Anne Przybylski,Cara Joyce et al.
Laura Cotiguala et al.
Background: Although donor-derived cell-free DNA (dd-cfDNA) serves as a monitoring tool for rejection, few studies have examined its utility in guiding immunosuppression management. Here, we present the largest kidney tra...
Safety of Tenecteplase in Stroke Mimics Compared With Acute Ischemic Stroke: A Retrospective Cohort Study [0.03%]
替奈普酶在卒中模拟患者中的安全性与急性缺血性卒中患者的对比：一项回顾性队列研究
A Shaun Rowe,Brian Wiseman,Leslie A Hamilton et al.
A Shaun Rowe et al.
Background: Acute ischemic stroke (AIS) accounts for 87% of all strokes and is associated with high morbidity and mortality. Stroke mimics, conditions that present with stroke-like symptoms but are not AIS, represent an i...
Comparative Study
Pharmacotherapy. 2026 Jan;46(1):e70112. DOI:10.1002/phar.70112 2026
Comment on "Acute Pharmacodynamic Effects of Oral Levodopa on Blood Pressure in Parkinson's Disease" [0.03%]
关于“左旋多巴口服对帕金森病患者血压急性药理效应”的评论
Malika Bouhaddi,Fabrice Vuiller,Jacques Regnard
Malika Bouhaddi
Response to Comment on "Acute Pharmacodynamic Effects of Oral Levodopa on Blood Pressure in Parkinson's Disease" [0.03%]
口服左旋多巴对帕金森病患者血压急性药理学效应的回复
Katherine Longardner,Cat Liu,Jeremiah D Momper et al.
Katherine Longardner et al.