Efficacy and safety of mirikizumab compared with currently approved biologic drugs for the treatment of ulcerative colitis: A systematic review and network meta-analysis [0.03%]
与当前批准的生物制剂药物治疗溃疡性结肠炎相比，Mirikizumab的有效性和安全性：系统评价和网络meta分析
Paweł Moćko,Magdalena Koperny,Katarzyna Śladowska et al.
Paweł Moćko et al.
Ulcerative colitis (UC) is a serious health problem that requires a constant need to identify new effective drugs. The aim of this study was to assess the efficacy and safety of mirikizumab compared with other biologic drugs approved for th...
Meta-Analysis
Pharmacotherapy. 2024 Oct;44(10):811-821. DOI:10.1002/phar.4611 2024
Delirium event and associated treatment modifications among older adults with Alzheimer's disease: An interrupted time-series analysis of Medicare data [0.03%]
基于医疗保险数据的阿尔茨海默病老年患者谵妄发作及相应治疗调整的一项时间序列分析研究
Ashna Talwar,Satabdi Chatterjee,Susan Abughosh et al.
Ashna Talwar et al.
Background: Both Alzheimer's disease (AD) and deliriogenic medications increase the risk of delirium in older adults. This study examined the association between delirium and the subsequent monthly use of anticholinergic,...
Influence of intravenous iron on bacterial infection risk immediately following kidney transplantation [0.03%]
静脉铁对肾移植后感染细菌的危险因素的影响
Spenser E January,Casey A Dubrawka,Kristin Progar et al.
Spenser E January et al.
Background: Kidney transplant recipients are at higher risk of infections due to immunosuppression, especially in the perioperative period after receiving induction therapy. Administration of iron has been linked to bacte...
Trends in the appropriateness of oral antibiotic prescriptions dispensed in the United States from 2010 to 2018 [0.03%]
2010年至2018年美国开具的口服抗生素处方的适宜性趋势
Mahek Garg,Veena Venugopalan,Scott M Vouri et al.
Mahek Garg et al.
Background: One of the goals established by the United States National Action Plan to Combat Antibiotic-Resistant Bacteria is to reduce inappropriate outpatient antibiotic prescriptions by 50% by 2020. Recent data on the ...
Real-world effectiveness of monoclonal antibody inhibitors of PCSK9 in patients with heterozygous familial hypercholesterolemia: A retrospective cohort study [0.03%]
人源PCSK9单克隆抗体抑制剂治疗异型杂合子家族性高胆固醇血症患者的有效性：回顾性队列研究
Rebecca Siemens,Mark Pryjma,Susan Buchkowsky et al.
Rebecca Siemens et al.
Background: Heterozygous familial hypercholesterolemia (HeFH) is a genetic condition that is associated with a high risk of atherosclerotic cardiovascular disease (ASCVD) due to elevated lipid levels. Proprotein convertas...
Incretin hormone agonists: Current and emerging pharmacotherapy for obesity management [0.03%]
incretin激素激动剂：肥胖管理的当前和新兴药物治疗
Ibrahim S Alhomoud,Azita H Talasaz,Preethi Chandrasekaran et al.
Ibrahim S Alhomoud et al.
Obesity continues to be a significant global health challenge, affecting over 800 million individuals worldwide. Traditional management strategies, including dietary, exercise, and behavioral interventions, often result in insufficient and ...
Ryan M Carnahan,Grant D Brown
Ryan M Carnahan
This article reflects on the potential value and many pitfalls of underpowered studies to help authors and readers consider whether and how they contribute meaningfully to the published literature. A basic introduction to power and sample s...
Physiologically based pharmacokinetic models for predicting lamotrigine exposure and dose optimization in pediatric patients receiving combination therapy with carbamazepine or valproic acid [0.03%]
基于生理的药动学模型预测卡马西平或丙戊酸钠联合拉莫三嗪治疗下的儿童患者暴露量及剂量优化
Zhiwei Liu,Wenxin Shao,Xingwen Wang et al.
Zhiwei Liu et al.
Introduction: Lamotrigine (LTG) is an antiepileptic drug that has been used in pediatric epilepsy as a combination therapy or monotherapy after stabilization in recent years. However, there are significant drug-drug inter...
Fixed dose daptomycin: An opportunity for pharmacokinetic/pharmacodynamic optimization in Staphylococcus aureus infections [0.03%]
固定剂量达托霉素：优化治疗金黄色葡萄球菌感染的药动学/药效学机会
Katie B Olney,Manjunath P Pai,Jenni K Thomas et al.
Katie B Olney et al.
Background: Daptomycin is a high-use intravenous antimicrobial agent affording the convenience of once-daily dosing. Prior studies suggest an opportunity to use a more operationally convenient fixed rather than weight-bas...
Lactated Ringer's versus normal saline in the management of acute diabetic ketoacidosis (RINSE-DKA) [0.03%]
乳酸林格氏液与生理盐水在急性糖尿病酮症酸中毒处理中的应用（RINSE-DKA）
Auriene Jamison,Adham Mohamed,Courtney Chedester et al.
Auriene Jamison et al.
Introduction: A mainstay in the acute management of diabetic ketoacidosis (DKA) is fluid resuscitation. Normal saline is recommended by the American Diabetes Association; however, it has been associated with hyperchloremi...
Comparative Study
Pharmacotherapy. 2024 Aug;44(8):623-630. DOI:10.1002/phar.4600 2024