Response to Comment on "Establishing discordance rate of estimated glomerular filtration rate between serum creatinine-based calculations and cystatin-C-based calculations in critically ill patients" [0.03%]
对“基于血清肌酐与胱抑素C计算的肾小球滤过率在危重症患者中的分歧率”一文的回复
Victoria L Williams,Anthony T Gerlach
Victoria L Williams
Transdermal rivastigmine as a therapeutic option in severe diphenhydramine-induced anticholinergic toxicity: A case report and literature review [0.03%]
穿透性 Rivastigmine 治疗重度苯海拉明抗胆碱能中毒的临床疗效：病例报告及文献回顾
Brian W Gilbert,Ruben D Santiago,Joel B Huffman et al.
Brian W Gilbert et al.
Diphenhydramine overdose is a common toxicological emergency characterized by anticholinergic symptoms such as delirium, hallucinations, and cardiovascular instability. Physostigmine, a centrally acting acetylcholinesterase inhibitor, is th...
Case Reports
Pharmacotherapy. 2025 Jun 10. DOI:10.1002/phar.70031 2025
Chloride dipstick to rapidly estimate urine sodium during diuresis in acute heart failure [0.03%]
心力衰竭时用氯化物试纸快速估计利尿期间的尿钠浓度
V Shah,David Cordwin,Scott L Hummel et al.
V Shah et al.
Background: Rapid assessment of diuretic efficacy is necessary in the treatment of acute decompensated heart failure. European guidelines advocate for the use of spot urinary sodium measurements, but recent data suggest u...
Pharmacokinetic and pharmacodynamic evaluation of sulbactam-durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex [0.03%]
连续静脉-静脉血液滤过患者感染耐碳青霉烯类产酸肠杆菌复合体时，舒巴坦-德拉巴坦的药代动力学和药效学评价
Wesley D Kufel,Nabil Zeineddine,Aliaa Fouad et al.
Wesley D Kufel et al.
Background: Drug databases currently do not provide dosing guidance for sulbactam-durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam-durl...
Pharmacotherapy research landscape and knowledge gaps of opioids in maternal and pediatric populations [0.03%]
药理学界针对母胎和儿科人群的阿片类药物研究现状与知识空白点分析
Aditi Shendre,Xiaofu Liu,ChienWei Chiang et al.
Aditi Shendre et al.
The use and misuse of opioids has surged in the past decade, with nearly half of the users being female. Although opioid use is lower among pregnant women, trends mirror the general population. While pediatric exposures largely occur throug...
Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double-blind placebo-controlled crossover trial [0.03%]
富马酸单水合物对儿童面肩肱型肌营养不良症患者运动功能的影响：一项多中心随机双盲安慰剂对照交叉试验
Ian R Woodcock,Katy de Valle,Anita Cairns et al.
Ian R Woodcock et al.
Background: Facioscapulohumeral muscular dystrophy (FSHD) is a rare, progressive muscle disease with no available disease-modifying therapy. Creatine monohydrate (CrM) has been shown to improve muscle strength in individu...
Predictive performance of population pharmacokinetic models in InsightRX® for model-informed precision dosing for Cefepime [0.03%]
InsightRX®中预测人群药代动力学模型指导头孢吡肟个体化用药的性能评估
Christina König,Joseph L Kuti,Andrew J Fratoni
Christina König
Background: Model-informed precision dosing (MIPD) is a promising tool used to ensure therapeutic antimicrobial concentrations. Model selection and sampling strategy might lead to different pharmacokinetic (PK) parameter ...
Proton pump inhibitor concomitant use to prevent oxaliplatin-induced peripheral neuropathy: Clinical retrospective cohort study [0.03%]
proton泵抑制剂联用预防奥沙利铂外周神经毒性的临床回顾队列研究
Keisuke Mine,Takehiro Kawashiri,Kohei Mori et al.
Keisuke Mine et al.
Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a major clinical challenge because it leads to discontinuation of chemotherapy. Omeprazole, a proton pump inhibitor (PPI), has been shown to prevent OIPN in ...
Retrospective cohort study of oral switch versus intravenous antibiotics for carbapenem-resistant enterobacterales and Pseudomonas aeruginosa infections on hospital discharge [0.03%]
一项出院时口服药物与静脉用抗生素治疗碳青霉烯类耐药肠杆菌目和铜绿假单胞菌感染的回顾性队列研究
Christen J Arena,Ali Abed,Rachel M Kenney et al.
Christen J Arena et al.
Objectives: To compare outcomes of oral switch versus intravenous antibiotics for the treatment of carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA) infections at hospital discharge. ...