Impact of Single Nucleotide Polymorphisms on Plasma Concentrations of Efavirenz and Lopinavir/Ritonavir in Chinese Children Infected with the Human Immunodeficiency Virus [0.03%]
单核苷酸多态性对中国人类免疫缺陷病毒儿童患者体内依非韦伦和洛匹那韦/利托那韦浓度影响的研究
Xia Liu,Qing Ma,Yan Zhao et al.
Xia Liu et al.
Single nucleotide polymorphisms (SNPs) in the genes that encode the cytochrome P450 (CYP) drug metabolizing enzymes and drug transporters have been reported to influence antiretroviral drug pharmacokinetics. Although primarily metabolized b...
Pharmacogenomics Implementation: Considerations for Selecting a Reference Laboratory [0.03%]
药物基因组学的实施：选择参考实验室的注意事项
Teresa T Vo,Gillian C Bell,Aniwaa Owusu Obeng et al.
Teresa T Vo et al.
One of the initial steps for implementing pharmacogenomics into routine patient care is selecting an appropriate clinical laboratory to perform the testing. With the rapid advances in genotyping technologies, many clinical laboratories are ...
IMP-6 Carbapenemase-Producing Enterobacteriaceae Bacteremia Successfully Treated with Amikacin-Meropenem in Two Patients [0.03%]
两例产碳青霉烯酶肠杆菌科细菌感染性休克患者成功使用阿米卡星-美罗培南治疗案例报告
Ichiro Nakakura,Yoshihiko Ogawa,Kota Sakakura et al.
Ichiro Nakakura et al.
Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) are becoming increasingly common worldwide. Although CPE infections can be fatal, few reports in the literature have described effective and successful treatments for inf...
Case Reports
Pharmacotherapy. 2017 Oct;37(10):e96-e102. DOI:10.1002/phar.1984 2017
Review of Opioid Pharmacogenetics and Considerations for Pain Management [0.03%]
阿片类药物药理遗传学的回顾及其在镇痛管理中应用的考虑因素
Aniwaa Owusu Obeng,Issam Hamadeh,Michael Smith
Aniwaa Owusu Obeng
Opioid analgesics are the standards of care for the treatment of moderate to severe nociceptive pain, particularly in the setting of cancer and surgery. Their analgesic properties mainly emanate from stimulation of the μ receptors, which a...
Ganciclovir-Resistant Cytomegalovirus Infection in Abdominal Solid Organ Transplant Recipients: Case Series and Review of the Literature [0.03%]
腹部实体器官移植受者抗ganciclovir巨细胞病毒感染的病例系列及文献回顾
Katherine E Rolling,Margaret R Jorgenson,Jillian L Descourouez et al.
Katherine E Rolling et al.
Ganciclovir-resistant cytomegalovirus (GR-CMV) is emerging as a significant infection in the abdominal transplant population. GR-CMV is difficult to manage, and treatment options are limited. We report a descriptive case series of 15 patien...
Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT) [0.03%]
人类白细胞抗原(HLA)基因和自然杀伤细胞免疫球蛋白样受体(KIR)类型对肝素诱导的血小板减少症(HIT)的影响
Jason H Karnes,Christian M Shaffer,Robert Cronin et al.
Jason H Karnes et al.
Heparin-induced thrombocytopenia (HIT) is an unpredictable, life-threatening, immune-mediated reaction to heparin. Variation in human leukocyte antigen (HLA) genes is now used to prevent immune-mediated adverse drug reactions. Combinations ...
Justin B Kaye,Lauren E Schultz,Heidi E Steiner et al.
Justin B Kaye et al.
Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose...
Impact of Pharmacogenetics on Efficacy and Safety of Statin Therapy for Dyslipidemia [0.03%]
药理基因组学对降脂他汀治疗疗效和安全性的影响力
Whitney D Maxwell,Laura B Ramsey,Samuel G Johnson et al.
Whitney D Maxwell et al.
Interindividual variability in response to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, with regard to both efficacy and safety is an obvious target for pharmacogenetic research. Many genes have been identified as...
Heather A Zierhut,Colleen A Campbell,Allison G Mitchell et al.
Heather A Zierhut et al.
Increased use of pharmacogenomic (PGx) testing in the clinical setting has revealed a number of challenges to providing this service. PGx is an important component of precision medicine that brings together the fields of genetics and clinic...
Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet? [0.03%]
向急性白血病的精准医疗迈进：我们准备好了吗？
Clement Chung,Hilary Ma
Clement Chung
Despite recent progress in the understanding of the molecular basis of acute leukemias, treatment options for these diseases have not changed significantly over the last few decades. We present a nonexhaustive summary of the current cytogen...