APOE ε4 and late-onset Alzheimer's disease in Syria: A case-control study [0.03%]
APOE ε4和叙利亚迟发性阿尔茨海默病：一项病例对照研究
Ibrahim Labbad,Lama A Youssef,Maha Rustom et al.
Ibrahim Labbad et al.
BackgroundThe apolipoprotein E (APOE) ε4 allele is the strongest known genetic risk factor for late-onset Alzheimer's disease (AD), but its prevalence and impact vary substantially across populations. No previous study has characterized AP...
A working feedback-based framework for goal-directed spatial memory deficits in Alzheimer's disease: Feedforward and feedback interactions along the RSC-MEC-CA1-RSC axis [0.03%]
阿尔茨海默病空间记忆障碍的工作反馈框架：RSC-MEC-CA1-RSC轴的前馈和反馈相互作用
Yaoyao Tian,Hong Qing,Zhenzhen Quan
Yaoyao Tian
Spatial navigation deficits are among the earliest and most clinically significant cognitive impairments in Alzheimer's disease (AD), particularly when navigation depends on goal-directed spatial memory. This review defines goal-directed sp...
Integrative machine learning reveals telomere-associated gene modules reflecting neuronal dysregulation in Alzheimer's disease [0.03%]
整合型机器学习揭示了阿尔茨海默病中反映神经元失调的端粒相关基因模块
Syeda Ummul Khair Fatima,Abdul Jabber,Mosammat Halima Khanam et al.
Syeda Ummul Khair Fatima et al.
BackgroundTelomere dysfunction contributes to cellular aging and genome instability, but telomere-associated transcription in Alzheimer's disease (AD) is poorly characterized. Telomere genes are commonly tested gene by gene, leaving it unce...
Subthreshold early white-matter hyperintensity increase predicts accelerated hippocampal and whole-brain atrophy in anti-amyloid-β immunotherapy [0.03%]
亚阈值早期白质高信号增加可预测抗淀粉样蛋白-β免疫治疗的海马体和全脑萎缩加速现象
Shiori Amemiya,Hidemasa Takao,Shoya Matsumoto et al.
Shiori Amemiya et al.
BackgroundAnti-amyloid-β (anti-Aβ) therapy slows cognitive decline but paradoxically accelerates whole-brain gray matter atrophy, complicating outcome prediction.ObjectiveTo identify early imaging markers that predict long-term prognoses....
Predicting progression from mild cognitive impairment to dementia with baseline neuropsychological test scores [0.03%]
基线神经心理学测试分数预测轻度认知障碍向痴呆发展
Natalie E Kurniadi,Joel S Steele,Nora Mattek et al.
Natalie E Kurniadi et al.
BackgroundAlthough neuropsychological scores have predicted progression from mild cognitive impairment (MCI) to dementia, past work has limitations, including small samples, limited batteries, and research cohorts.ObjectiveThis study sought...
Predicting progression from mild cognitive impairment to dementia with baseline neuropsychological test scores [0.03%]
基于基线神经心理学检测评分预测轻度认知障碍向痴呆发展
Natalie E Kurniadi,Joel S Steele,Nora Mattek et al.
Natalie E Kurniadi et al.
BackgroundAlthough neuropsychological scores have predicted progression from mild cognitive impairment (MCI) to dementia, past work has limitations, including small samples, limited batteries, and research cohorts.ObjectiveThis study sought...
Concordance between plasma biomarkers of phosphorylated tau and tau-PET: A narrative review [0.03%]
磷酸化tau的血浆生物标志物与Tau-PET的一致性：叙述性综述
Anna S Van Houwelingen,Meike W Vernooij,Marie R Vermeiren et al.
Anna S Van Houwelingen et al.
Plasma phosphorylated tau (p-tau) and tau positron emission tomography (PET) are key biomarkers for detecting tau pathology in Alzheimer's disease (AD), offering both diagnostic and prognostic value. However, the concordance between plasma ...
Concordance between plasma biomarkers of phosphorylated tau and tau-PET: A narrative review [0.03%]
磷酸tau血浆生物标志物与tau-PET一致性：综述文章
Anna S Van Houwelingen,Meike W Vernooij,Marie R Vermeiren et al.
Anna S Van Houwelingen et al.
Plasma phosphorylated tau (p-tau) and tau positron emission tomography (PET) are key biomarkers for detecting tau pathology in Alzheimer's disease (AD), offering both diagnostic and prognostic value. However, the concordance between plasma ...
Beyond binary classification: A tiered claims-based algorithm for Alzheimer's disease and related dementias in Medicare [0.03%]
超越二元分类：医疗保险中阿尔茨海默病和相关痴呆症的分层索赔算法
Sara Knox,Mary Dooley,Maxwell Cutty et al.
Sara Knox et al.
BackgroundAdministrative data is widely used to identify Alzheimer's disease and related dementias (ADRD), yet commonly applied algorithms (e.g., the Chronic Conditions Warehouse [CCW] algorithm) rely on binary classification that may obscu...
Thermodynamic impedance mismatch in neurodegeneration: A biophysical framework for the prediction of amyloid-related imaging abnormalities [0.03%]
神经退行性病变中的热力学阻抗不匹配：预测淀粉样蛋白相关影像异常的生物物理框架
Kevin Thorsen Baird
Kevin Thorsen Baird
Amyloid-related imaging abnormalities (ARIA) represent a significant iatrogenic complication of anti-amyloid monoclonal antibody therapies. To address this, we propose the Impedance Mismatch Theory as a theoretical framework and hypothesis,...