Regulated neuronal death in Alzheimer's disease: Crosstalk and convergence of apoptosis, pyroptosis, senescence, and ferroptosis [0.03%]
阿尔茨海默病中的调控神经元死亡：凋亡、焦亡、衰老和铁依赖性细胞死亡的相互作用及汇聚
Yang Zhang,Dongmei Zhang,Hua Xiao
Yang Zhang
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. Despite its rapidly increasing global prevalence, effective disease-modifying therapies remain limited. Neuronal los...
Association between lipid levels and dementia risk among older Ghanaian adults [0.03%]
脂质水平与加纳老年人认知风险的相关性研究
Foster Appiah,David Larbi Simpong,Esther Marfo et al.
Foster Appiah et al.
BackgroundDementia is an escalating global public health concern, with Alzheimer's disease accounting for the largest proportion of cases. However, evidence on its association with lipid abnormalities remains limited in low- and middle-inco...
Nicotinamide mononucleotide supplementation modulates gut microbiota and metabolites to mitigate Alzheimer's disease pathology in APP/PS1 mice [0.03%]
烟酰胺单核苷酸补充通过调节肠道微生物群和代谢物减轻APP / PS1小鼠的阿尔茨海默病病理学
Huili Zhou,Xiaodong Zhao,Yuan Li et al.
Huili Zhou et al.
BackgroundEmerging evidence indicates that gut microbiome dysbiosis may be linked to Nicotinamide adenine dinucleotide (NAD+) deficiency during Alzheimer's disease (AD) progression, a condition potentially alleviated by nicotinamide mononuc...
Using community engagement studios to involve persons living with dementia and their care partners in research design [0.03%]
利用社区参与工作室让痴呆症患者及其看护者参与到研究设计中
Alejandra Martinez-Pereira,Lisa A Mistler,Susan Tarczewski et al.
Alejandra Martinez-Pereira et al.
BackgroundPersons living with dementia (PLWD) and their care partners face unique challenges in participating in research studies. Community Engagement Studios (CES) provide a framework for researchers to work directly with community member...
Edentulism and risk of all-cause dementia and Alzheimer's disease: A competing risk analysis by cognitive status [0.03%]
牙缺失与全因痴呆和阿尔茨海默病风险的关系：一种按认知状态分组的竞争性风险分析方法
Ruotong Liu,Xiang Qi,Huabin Luo et al.
Ruotong Liu et al.
BackgroundEdentulism is an irreversible marker of severe oral disease and systemic disadvantage, yet robust epidemiological evidence linking edentulism to clinically diagnosed dementia remains limited.ObjectiveThis study uses clinically dia...
Modulation of mitochondrial quality by exercise mimetics: A potential strategy for the prevention and treatment of Alzheimer's disease [0.03%]
运动模拟对线粒体质量的调节作用：阿尔茨海默病预防和治疗的一种潜在策略
Zhiwei Ke,Bo Wang,Rongxiang Liang
Zhiwei Ke
Decline in mitochondrial quality is a prominent pathological feature of Alzheimer's disease (AD), manifested by impaired energy metabolism, disrupted mitochondrial biogenesis, abnormal mitochondrial dynamics, and defective mitophagy. Increa...
Plasma amyloid-β predicts amyloid-β accumulation in PET A- non-demented participants [0.03%]
血浆淀粉样蛋白-β预测PET检测Aegative非痴呆参与者的淀粉样蛋白-β聚集现象
Alexandra Gogola,Ann D Cohen,Brian J Lopresti et al.
Alexandra Gogola et al.
BackgroundPlasma biomarkers for Alzheimer's disease (AD) studies, but much remains unknown about the associations of plasma and PET biomarkers of amyloid-β (Aβ).ObjectiveTo determine the associations of plasma Aβ with PET Aβ accumulatio...
Differential associations of cognitive screeners with biological, psychological, and cognitive factors in high-risk older adults [0.03%]
高危老年人中认知筛查与生物、心理和认知因素的关联性分析
Michaela Rice,Kathleen Angela Willoughby-Dudley,Mengting Lin et al.
Michaela Rice et al.
Background: Dementia rates have accelerated in recent decades, yet our ability to screen for and predict who is at risk remains limited. The Montreal Cognitive Assessment (MoCA) and the Alzheimer's Disease Assessment Scal...
Mapping dementia research in Morocco: A scoping review of epidemiological, genetic, and therapeutic evidence [0.03%]
摩洛哥痴呆症研究的图谱：流行病学、遗传和治疗证据的综述性研究
Youssef Razouqi,Hassan El-Abid,Loubna Khalki
Youssef Razouqi
BackgroundDementia represents a major global health challenge, particularly in low- and middle-income countries (LMICs). Morocco, facing rapid population ageing, lacks integrated epidemiological and translational research on Alzheimer's dis...
Clinical relevance of automated cerebrospinal fluid amyloid and tau biomarkers in Indian patients with early onset cognitive decline: Insights from the AIIMS-Delhi Study Cohort of Early/late oNset Dementia (ASCEND) [0.03%]
印度早期认知功能下降患者的自动脑脊液淀粉样蛋白和tau生物标志物的临床意义：来自印度医学科学院- Delhi研究队列（ASCEND）早发/晚发痴呆组的见解
Anu Gupta,Anjali Anjali,Arnab Adhya et al.
Anu Gupta et al.
Automated cerebrospinal fluid (CSF) biomarkers have been underexplored in early onset dementias (EOD) within the South-Asian context. In our ongoing ASCEND cohort (tertiary care center in India), we evaluated the added value of incorporatin...