Efficacy and safety of a novel, extended-release rivastigmine transdermal patch (TW-4752N) in patients with Alzheimer's disease: A 24-week randomized, double-blind trial with a 28-week open-label extension [0.03%]
一种新型盐酸瑞斯帕丁透皮贴片(TW-4752N)治疗阿尔茨海默病患者的疗效和安全性：一项为期24周的随机、双盲试验，并延长了为期28周的开放标签期研究
Yu Nakamura,Takaya Kurokawa,Shun Terashima et al.
Yu Nakamura et al.
BackgroundRivastigmine may offer greater efficacy and convenience of use with a novel formulation than previously reported.ObjectiveTo evaluate the efficacy and safety of a novel, twice-weekly rivastigmine patch (TW-4752N) (TW) in Alzheimer...
Surface-based but not voxel-based morphometry reveals structural abnormalities in individuals with subjective cognitive decline [0.03%]
基于表面的形态测量而非体素的形态测量可揭示主观认知下降个体的大脑结构异常
Laura Serra,Sabrina Bonarota,Carlotta Di Domenico et al.
Laura Serra et al.
BackgroundSubjective cognitive decline (SCD) refers to individuals who perceive a decrease in their cognitive functioning despite no detectable deficits on neuropsychological tests, and may represent the earliest clinical stage of Alzheimer...
Hippocampal transcriptome-wide association analysis of shared genetic risks between posttraumatic stress disorder and Alzheimer's disease [0.03%]
全转录组关联分析海马基因组中 PTSD 和阿尔茨海默病的共享遗传风险
Eric Du,Jing Tian
Eric Du
BackgroundThe etiopathogenesis of Alzheimer's disease (AD) is puzzled by the heterogeneous nature of this neurodegenerative disorder. In recent years, clinical and basic research has accentuated a relationship between post-traumatic stress ...
Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease [0.03%]
血浆可溶性TREM2与阿尔茨海默病高风险的轻度认知障碍老年人的磷酸化tau蛋白相关性研究
Prita R Asih,Cameron W Morris,Hong Wang et al.
Prita R Asih et al.
BackgroundCSF and blood soluble TREM2 (sTREM2) levels have been found to increase at early stage of Alzheimer's disease (AD). The relationships between sTREM2, AD-related biomarkers, and other neuroinflammation biomarkers remain unclear. Mo...
Alzheimer's disease amyloid-β affects membrane structure and mechanical properties of human neural progenitors [0.03%]
阿尔茨海默病淀粉样蛋白-β影响人神经前体细胞膜结构和机械性能
Sophie Asnacios,Galya Staneva,Gabriel Thon et al.
Sophie Asnacios et al.
BackgroundIn Alzheimer's disease (AD), neurogenesis and neuroplasticity are severely affected but there is not yet a consensus about the underlying mechanisms. The amyloid cascade hypothesis is associated with overproduction of the amyloid-...
Dysregulated mTOR signaling in Alzheimer's disease: Linking pathogenic mechanisms to emerging therapeutic strategies [0.03%]
阿尔茨海默病中的失调的mTOR信号：连接致病机理与新兴治疗方法
Siqi Zhang,Tianyi Wang,Guocheng Xue et al.
Siqi Zhang et al.
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline and multifaceted pathogenic mechanisms (including amyloid-β [Aβ] plaques, tau neurofibrillary tangles, synaptic dysfunction, a...
Posterior cingulate cortex atrophy across the Alzheimer's disease spectrum: A cross-sectional MRI study linking volumetrics to cognitive decline [0.03%]
阿尔茨海默病谱系联络区萎缩的磁共振成像体积分析及其与认知衰退的关系研究
Iman Kiani,Ghazal Mohseni,Tayyebeh Hassani et al.
Iman Kiani et al.
BackgroundThe posterior cingulate cortex (PCC) is a metabolic hub within the default-mode network and an early target of Alzheimer's disease (AD) pathology, yet its quantitative relationship with cognition across the normal aging-mild cogni...
Comparative efficacy and safety of different brexpiprazole doses for agitation in Alzheimer's disease: A systematic review and network meta-analysis [0.03%]
鲁拉西酮不同剂量治疗阿尔茨海默病激越的疗效和安全性系统综述与网络meta分析
Mahmoud Kandeel,Maryam Mahmoud
Mahmoud Kandeel
BackgroundAgitation in Alzheimer's disease significantly impacts patient outcomes and caregiver burden. Brexpiprazole has emerged as a promising treatment option, but optimal dosing remains unclear.ObjectiveTo evaluate the comparative effic...
Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact [0.03%]
加拿大神经退行性疾病队列的周围炎症：发生率、决定因素和影响
Bruna Seixas-Lima,Pedro Rosa-Neto,Natalie A Phillips et al.
Bruna Seixas-Lima et al.
Background"Inflammaging" describes chronic low-grade inflammation observed in aging individuals. It may play a major role in neurodegeneration.ObjectiveTo assess blood inflammatory markers in older adults. We hypothesized that elevated infl...
Home-based, caregiver-assisted multimodal exercise and cognitive training via videoconferencing for older adults with mild dementia: A mixed-methods pilot study [0.03%]
基于视频会议的居家护理人员辅助多模式锻炼和认知训练的试点研究：老年人轻度痴呆患者的混合方法研究
Dandan Xue,Doris Sf Yu,Ling Yue et al.
Dandan Xue et al.
BackgroundEvidence on the effects of caregiver-assisted combined exercise and cognitive interventions for persons with dementia (PwD) is inconsistent.ObjectiveThis study aimed to evaluate the feasibility and preliminary effects of a home-ba...