Pan-cancer genetic profiles of mitotic DNA integrity checkpoint protein kinases [0.03%]
有丝分裂DNA完整检查点蛋白激酶的泛癌遗传特征
Ayana Meegol Rasteh,Hengrui Liu,Panpan Wang
Ayana Meegol Rasteh
Background: The mitotic DNA integrity checkpoint signaling pathway is potentially involved in cancers that regulate genomic stability where protein kinases play a pivotal role. 16 total protein kinase genes are involved in this pathway: ATM...
Predictive role of HPGD gene in carcinogenesis and immune environment monitoring in human cervical cancer [0.03%]
HPGD基因在人类宫颈癌的发生及免疫环境监测中的预测作用研究
Mingzhu Zhai,Weihua Yang,Chen Zou et al.
Mingzhu Zhai et al.
Background15-Hydroxyprostaglandin dehydrogenase (15-PGDH, gene symbol HPGD) is considered a tumor suppressor, and its expression is often proportional to the anticancer response. However, the clinical significance of HPGD/15-PGDH in predict...
High TCTA expression is an adverse prognostic biomarker in acute myeloid leukemia [0.03%]
高TCTA表达是急性髓系白血病的不良预后生物标志物
Yunli Shao,Tong Qin
Yunli Shao
BackgroundAcute myeloid leukemia (AML) prognosis varies greatly, underscoring the need for novel biomarkers to improve patient stratification. T-cell leukemia translocation-associated gene (TCTA) has emerged as a potential player in hematol...
A fatty acid metabolism-related genes model for predicting the prognosis and immunotherapy effect of lung adenocarcinoma [0.03%]
用于预测肺腺癌预后和免疫治疗效果的脂肪酸代谢相关基因模型
Lingxue Tang,Tong Wang
Lingxue Tang
ObjectiveLung adenocarcinoma (LUAD) is a common and highly heterogeneous malignancy cancer with increasing morbidity and mortality. Dysregulation of fatty acid metabolism (FAM) has been identified as a key regulator of LUAD progression. Our...
Hsa_circ_0002346 inhibits proliferation, invasion, and migration of breast cancer cells and promotes apoptosis: A novel potential biomarker for breast cancer [0.03%]
Hsa_circ_0002346抑制乳腺癌细胞的增殖，侵袭和迁移并促进凋亡：乳腺癌的一种新型潜在生物标志物
Yixin Zhou,Linyi Wang,Wangjin Xu et al.
Yixin Zhou et al.
BackgroundCircular RNA hsa_circ_0002346 has been implicated in the progression of various tumors, yet the functional role in breast cancer remains poorly understood. This study aimed to investigate the significance of hsa_circ_0002346 in br...
Tumor immune microenvironment of colorectal cancer identifies novel prognostic signature and potential therapeutic drugs [0.03%]
结肠癌肿瘤免疫微环境识别新的预后特征和潜在治疗药物
Weijie Fu,Yunhan Gao,Zhenhai Chen et al.
Weijie Fu et al.
Background: The tumor microenvironment (TME) is increasingly recognized as a key player in colorectal cancer biology, however, its potential for improving diagnosis, prognosis, and treatment remains unclear. The major aim of this study is t...
Diagnostic utility of lipocalin 2 and metalloproteinase 9 levels in early-stage endometrial cancer [0.03%]
早期子宫内膜癌诊断中脂钙蛋白2和基质金属蛋白酶9水平的实用价值
Songül Ünüvar,Rauf Melekoğlu,Hande Yüce et al.
Songül Ünüvar et al.
Background: Endometrial cancer (EC) is the fourth most common gynecologic malignancy among women. Histopathologic examination is considered gold-standard for diagnosis of EC. However, these examinations sometimes not be u...
L1CAM is not prognostic factor in HPV-associated adenocarcinoma and adenosquamous cell carcinoma of the uterine cervix [0.03%]
L1CAM并不是与HPV相关的子宫颈腺癌和腺鳞状细胞癌的预后因素
Jaroslav Klát,Martina Romanová,Vladimír Židlík et al.
Jaroslav Klát et al.
Background: Cervical cancer (CC) is the fourth most common malignancy. The significant prognostic factors are tumor size and lympho-vascular space invasion. Considering that these are nonspecific factors, research has bee...
Identification of RNA-binding protein RBMS3 as a potential biomarker for immunotherapy in bladder cancer [0.03%]
膀胱癌免疫治疗潜在生物标志物RBMS3的鉴定
Tarimo Fredrick Praygod,Jinlong Li,Hongwei Li et al.
Tarimo Fredrick Praygod et al.
RNA-binding protein (RBP) plays pivotal roles in the malignant progression of cancer by regulating gene expression. In this paper, we aimed to develop RBP-based prognostic signature and identify critical hub RBPs in bladder cancer (BLCA). F...
KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE [0.03%]
KIF18A通过上调CENPE激活PI3K/AKT途径促进宫颈鳞癌进展
Fengyi Sun,Tiantian Zhao
Fengyi Sun
Background: Cervical cancer is a prevalent malignancy that significantly contributes to morbidity and mortality rates among women in developing nations. Although the association of KIF18A with various cancers has been est...