From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform [0.03%]
从胰腺血液生物标志物载脂蛋白A2的发现到临床应用
Ayumi Kashiro,Giman Jung,Kazufumi Honda
Ayumi Kashiro
Pancreatic cancer is a rare and refractory cancer, and the development of blood biomarkers for the enrichment of high-risk individuals who have risk factors for pancreatic cancer from the asymptomatic population is an unmet medical need. We...
Multi-cancer early detection tests: Attributes for clinical implementation [0.03%]
多癌症早期检测测试：临床实施属性分析
Jon O Ebbert,Ernest T Hawk,Christopher V Chambers et al.
Jon O Ebbert et al.
Guideline-recommended screening programs exist for only a few single-cancer types, and these cancers represent less than one-half of all new cancer cases diagnosed each year in the U.S. In addition, these "single-cancer" standard of care (S...
Circulating tumor HPV DNA, antibodies to HPV16 early proteins, and oral HPV16 DNA as biomarkers for HPV-related oropharyngeal cancer screening [0.03%]
用于筛查HPV相关口咽癌的生物标志物：循环肿瘤HPV DNA，针对HPV16早期蛋白的抗体和口腔HPV16 DNA
Kristina R Dahlstrom,Andrew T Day,Victor M Alvarez et al.
Kristina R Dahlstrom et al.
BackgroundOropharyngeal cancer rates continue to rise with no effective screening method. Persistent oral oncogenic human papillomavirus (HPV), antibodies to HPV16 early (E) oncoproteins, and circulating tumor HPV DNA (ctHPVDNA) are biomark...
Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow [0.03%]
组织和多种癌症类型的空间蛋白质组学和转录组学特征，包括去钙化的骨髓
Cecilia Cs Yeung,Daniel C Jones,David W Woolston et al.
Cecilia Cs Yeung et al.
BackgroundRecent technologies enabling the study of spatial biology include multiple high-dimensional spatial imaging methods that have rapidly emerged with different capabilities evaluating tissues at different resolutions for different sa...
A potential target for the future treatment of malignant pleural effusion: Monocyte chemoattractant protein-1 (MCP-1) [0.03%]
恶性胸腔积液治疗的潜在靶点：单核细胞趋化蛋白-1(MCP-1)
Fatih Tekin,Deniz Koksal,Z Gunnur Dikmen et al.
Fatih Tekin et al.
Background and Aim: Malignant pleural effusion (MPE) is a common clinical problem. Management options are mainly pleurodesis and drainage, and have remained unchanged for years. Novel therapies that target the molecules responsible for flui...
A simplified MyProstateScore2.0 for high-grade prostate cancer [0.03%]
高分级前列腺癌的简化版MyProstateScore2.0
Tiffany M Tang,Yuping Zhang,Ana M Kenney et al.
Tiffany M Tang et al.
Background: The limited diagnostic accuracy of prostate-specific antigen screening for prostate cancer (PCa) has prompted innovative solutions, such as the state-of-the-art 18-gene urine test for clinically-significant PCa (MyProstateScore2...
DNA damage of peripheral blood lymphocytes as a dual biomarker: Diagnostic and treatment response in woman breast cancer patients [0.03%]
外周血淋巴细胞的DNA损伤作为双效生物标志物：女性乳腺癌患者的诊断和治疗反应
Ana Rita Guedes,Jorge Pinto Soares,Renato Cunha et al.
Ana Rita Guedes et al.
BackgroundBreast cancer is the leading malignancy among women and the lack of ideal early biomarkers hampers diagnosis and treatment monitoring. Genomic instability, central to breast cancer development, makes DNA damage a potential biomark...
Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody [0.03%]
新制备的单克隆抗体在不同胃癌亚型中DCLK1的"S"异构体的临床意义
Mahdieh Razmi,Ali-Ahmad Bayat,Nafiseh Mortazavi et al.
Mahdieh Razmi et al.
BackgroundDoublecortin-like kinase 1 (DCLK1) isoforms play distinct roles in the progression of gastrointestinal cancers. For the first time ever, the current study aimed to generate DCLK1-S-specific monoclonal antibodies (mAbs) to evaluate...
Apolipoprotein C1 and apoprotein E as potential therapeutic and prognostic targets for adrenocortical carcinoma [0.03%]
载脂蛋白C1和载脂蛋白E作为肾上腺皮质癌的潜在治疗和预后靶点
Shaojin Li,Shuixiu Xiao,Yongli Situ
Shaojin Li
BackgroundApolipoprotein C1 (APOC1) and Apoprotein E (APOE) play important roles in lipid transport and metabolism. In recent years, APOC1 and APOE have been shown to play key roles in the occurrence and development of various cancers. Howe...
Serum CA19-9 as a predictor of incident metabolic syndrome in obese middle-aged and older men: A 9-year cohort study [0.03%]
肥胖中老年男性血清CA19-9作为新发代谢综合征预测因子的九年的队列研究
Chun-Wei Yu,Li-Wei Wu,Je-Ming Hu et al.
Chun-Wei Yu et al.
BackgroundThe status of carbohydrate antigen 19-9 (CA19-9) in metabolic syndrome (MetS) is unknown.ObjectiveTo investigate the association between serum CA19-9 levels and incident metabolic syndrome in obese middle-aged and older men.Method...