Hypoxia inducible factor-1α promotes non-small cell lung cancer progression by activating leptin receptor transcription [0.03%]
缺氧诱导因子-1α通过激活瘦素受体转录促进非小细胞肺癌进展
Yan Li,Bo Chen,Shuangshuang Wu et al.
Yan Li et al.
BackgroundHypoxia and leptin receptors (also called obesity receptors, OB-R) are evident markers of tumor progression and have been demonstrated to be essential oncogenes in a variety of cancers. However, the specific role of OB-R in lung c...
Development of a multiplexed lateral flow assay for the serologic detection of HPV-associated head and neck cancer [0.03%]
一种用于人乳头状瘤病毒相关头颈部癌症血清学检测的多重侧向流动分析法的研发
Ching-Wen Hou,Pankaj Kumar,Stacy Williams et al.
Ching-Wen Hou et al.
BackgroundAmong head and neck squamous cell carcinomas (HNSCCs), the incidence of oropharyngeal cancer (OPC) has been increasing in recent decades. Human papillomavirus (HPV) type 16 is associated with the majority of OPC. Circulating antib...
Biomarkers and potential function analysis of triple-negative breast cancer screening based on bioinformatics [0.03%]
基于生物信息学的三阴性乳腺癌筛查标志物及其潜在功能分析
Xing Chen,Xiaodan Tan,Zhe Peng et al.
Xing Chen et al.
This study aims to identify and validate potential endogenous biomarkers for triple-negative breast cancer (TNBC). TNBC microarray data (GSE38959, GSE53752) were retrieved from the Gene Expression Omnibus (GEO) database, and principal compo...
Bioinformatics screened of biomarkers for the prognosis of hepatocellular carcinoma [0.03%]
肝细胞癌预后生物标志物的生物信息学筛选研究
Chunxu Bao,Tingting Liu,Guiling Hu et al.
Chunxu Bao et al.
BackgroundThis study aimed to identify hub genes linked to hepatocellular carcinoma (LIHC) pathogenesis using bioinformatics analysis.MethodA total of 3865 samples from 12 datasets in the HCCDB database were analyzed to identify prognostic ...
Identification of key genes related to cancer associated fibroblasts in neuroblastoma: A comprehensive bioinformatics approach [0.03%]
利用综合生物信息学方法鉴定与神经母细胞瘤相关癌相关成纤维细胞的关键基因
Zhao Qianyun,Wang Jianjun,Fan Kaisi et al.
Zhao Qianyun et al.
BackgroundNeuroblastoma (NB) is one of the most common and aggressive pediatric solid tumors, characterized by a highly complex pathogenesis. Within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) constitute a major c...
Identifying diagnostic markers and establishing prognostic model for lung cancer based on lung cancer-derived exosomal genes [0.03%]
基于肺癌来源的外泌体基因鉴定诊断标志物和建立预后模型
Yongxiang Zhang,Feng Chen,Yuqi Cao et al.
Yongxiang Zhang et al.
Background: Lung cancer (LC) is the most common malignancy and the leading cause of cancer death. LC-derived exosomes have been found to play a critical role in tumor initiation, progression, metastasis and drug resistance. Therefore, the o...
Development and validation of machine learning models for early diagnosis and prognosis of lung adenocarcinoma using miRNA expression profiles [0.03%]
基于miRNA表达谱的机器学习模型在肺腺癌早期诊断和预后中的建立及验证
Lin Lin,Yongxia Bao
Lin Lin
ObjectiveStudy aims to develop diagnostic and prognostic models for lung adenocarcinoma (LUAD) using Machine learning（ML）algorithms, aiming to enhance clinical decision-making accuracy.MethodsData from The Cancer Genome Atlas (TCGA) for LUAD ...
Stepwise single-cell data identifies RNA binding proteins associated with the development of head and neck cancer and tumor microenvironment remodeling [0.03%]
基于单细胞数据的步进分析鉴定与头颈癌发生发展及肿瘤微环境重塑相关RNA结合蛋白
Bin Yang,Wei Sun,Ping Peng et al.
Bin Yang et al.
Background: Head and neck squamous cell carcinoma (HNSC) is a globally prevalent malignancy with high mortality rates. RNA-binding proteins (RBPs) are crucial regulators of gene expression and play significant roles in cancer development. H...
Systematic exploration of prognostic alternative splicing events related to tumor immune microenvironment of Clear Cell Renal Cell Carcinoma [0.03%]
系统探索透明细胞肾细胞癌肿瘤免疫微环境相关的预后可变剪接事件
Hongwei Wu,Yuchuan Zhou,Xi Wang et al.
Hongwei Wu et al.
BackgroundPathologically, clear cell renal cell carcinoma (ccRCC) is the most common type of renal carcinoma, with high heterogeneity and poor prognosis. There is increasing evidence that alternative splicing (AS) is involved in tumor evolu...
Exploring the regulatory role of CNPY3 as a prognostic biomarker on human glioma cell migration, invasion and immune infiltration [0.03%]
探索CNPY3作为胶质瘤预后生物标志物调控胶质瘤细胞迁移、侵袭及免疫浸润的作用机制
Lu Zhan,Fanyue Zeng,Jie Zheng et al.
Lu Zhan et al.
BackgroundCanopy FGF signalling regulator 3 (CNPY3) is involved in immune regulation, tumorigenesis and development, nevertheless, its role in glioma remains largely unexplored. Our study aimed to explore the regulatory role of CNPY3 as a p...