Evaluating the efficacy of PARP inhibitor in ARID1A-deficient colorectal cancer: A ex vivo study [0.03%]
ARID1A缺陷型结直肠癌中PARP抑制剂疗效的评估：一种体外研究方法
Rui Zong,Ping Zhou,Shaojie Qin et al.
Rui Zong et al.
ARID1A mutations are a common occurrence in colorectal cancer (CRC) cells, but clinical therapeutic options targeting this anomaly remain unavailable. The loss of ARID1A functionality compromises DNA damage repair processes, potentially cau...
Knockdown of HSF1 inhibits invasion, metastasis, and proliferation of endometrial carcinoma cells while promoting apoptosis [0.03%]
HSF1敲低抑制子宫内膜癌细胞侵袭、转移和增殖并促进其凋亡
Haixia Liu,Xiao Gu,Jinlai Meng et al.
Haixia Liu et al.
BackgroundHeat shock factor 1 (HSF1), the principal transcriptional regulator of cellular stress responses, has been exhibited to play a role in the progression of various human cancer types. However, the function of HSF1 in endometrial can...
CXCL1 and CXCL8: Reliable and feasible biomarkers differentiating intrapulmonary metastasis from multiple primary neoplasms in non-small cell lung cancers [0.03%]
CXC基序配体1和8鉴别非小细胞肺癌内肺转移与多原发肿瘤的可靠性和可行性的生物标志物研究
Ao Liu,Tianlin Sun,Tong Qiu et al.
Ao Liu et al.
ObjectiveIn NSCLC, the main approach to differentiate between intrapulmonary metastases (IPM) and multiple primary lung cancer (MPLC) is to integrate histopathological and genomic information. Here, we identified viable biomarkers that can ...
Serum Protein Profiling as theranostic biomarkers for Left- and Right-Sided Colon Cancer using Luminex® technology [0.03%]
采用Luminex技术研究血清蛋白作为左半结肠癌和右半结肠癌诊疗标志物的差异性
Amani Attia,Azza Habel,Weili Xu et al.
Amani Attia et al.
BackgroundGiven the differences between malignancies arising from different segments of the colon, specific theranostic biomarkers can be linked to either Right-sided (RCC) or Left-sided colon cancer (LCC).ObjectiveAnalysis of 65 serum prot...
Panax notoginseng improves the sensitivity of non-small cell lung cancer to cisplatin by inhibiting Akt signaling [0.03%]
三七通过抑制Akt信号通路增强非小细胞肺癌顺铂敏感性
Lizhen Pan,Dandan Zhang,Qiqi Shao et al.
Lizhen Pan et al.
BackgroundCisplatin (DDP) resistance is a major challenge in the management of non-small cell lung cancer (NSCLC). Panax notoginseng has anticancer effects on a variety of solid tumors, but data on NSCLC and DDP resistance are lacking.Objec...
BUB1, miR-495-3p, and E2F1/E2F8 axis is associated with poor prognosis of breast cancer patients and infiltration of Th2 cells in the tumor microenvironment [0.03%]
BUB1、miR-495-3p和E2F1/E2F8轴与乳腺癌患者的不良预后及肿瘤微环境中Th2细胞浸润有关
Rajeev Nema,Ashok Kumar
Rajeev Nema
Breast cancer, the most common cancer in women, is characterized by cell cycle dysregulation and chromosome segregation errors, leading to mitotic catastrophe and genomic instability. Understanding these molecular mechanisms is crucial for ...
External validation of CEA and CA125 prediction model for lymph node metastasis in endometrial cancer: A multi-institute cohort study [0.03%]
基于多中心队列的子宫内膜癌淋巴结转移CEA和CA125预测模型的外部验证研究
Hao Lin,Hung-Chun Fu,Szu-Yu Huang et al.
Hao Lin et al.
BackgroundWe previously utilized pretreatment tumor markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 125 (CA125) for predicting lymph node metastasis (LNM) in endometrioid endometrial cancer (EC).ObjectiveThe aim of this study was ...
The effect of low-intensity resistance exercise training on Serum tumor biomarkers and quality of life in women with breast cancer: A randomized controlled trial [0.03%]
低强度阻抗运动训练对乳腺癌女性患者血清肿瘤生物标志物及生活质量的影响：一项随机对照试验
Deniz Kocamaz,Nahide Ayhan Fidancioğlu,Ramazan Cihad Yilmaz et al.
Deniz Kocamaz et al.
BackgroundAs the role of physical activity in breast cancer management gains increasing recognition, understanding the effects of aerobic exercise on patients' quality of life and biological markers has emerged as a critical area of researc...
Randomized Controlled Trial
Cancer biomarkers : section A of Disease markers. 2025 Mar;42(3):18758592251329201. DOI:10.1177/18758592251329201 2025
Brain tumor segmentation and detection in MRI using convolutional neural networks and VGG16 [0.03%]
基于卷积神经网络和VGG16的脑肿瘤MRI图像分割与检测
Shunmugavel Ganesh,Ramalingam Gomathi,Suriyan Kannadhasan
Shunmugavel Ganesh
BackgroundIn this research, we explore the application of Convolutional Neural Networks (CNNs) for the development of an automated cancer detection system, particularly for MRI images. By leveraging deep learning and image processing techni...
Hypoxia inducible factor-1α promotes non-small cell lung cancer progression by activating leptin receptor transcription [0.03%]
缺氧诱导因子-1α通过激活瘦素受体转录促进非小细胞肺癌进展
Yan Li,Bo Chen,Shuangshuang Wu et al.
Yan Li et al.
BackgroundHypoxia and leptin receptors (also called obesity receptors, OB-R) are evident markers of tumor progression and have been demonstrated to be essential oncogenes in a variety of cancers. However, the specific role of OB-R in lung c...