Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody [0.03%]
新制备的单克隆抗体在不同胃癌亚型中DCLK1的"S"异构体的临床意义
Mahdieh Razmi,Ali-Ahmad Bayat,Nafiseh Mortazavi et al.
Mahdieh Razmi et al.
BackgroundDoublecortin-like kinase 1 (DCLK1) isoforms play distinct roles in the progression of gastrointestinal cancers. For the first time ever, the current study aimed to generate DCLK1-S-specific monoclonal antibodies (mAbs) to evaluate...
Apolipoprotein C1 and apoprotein E as potential therapeutic and prognostic targets for adrenocortical carcinoma [0.03%]
载脂蛋白C1和载脂蛋白E作为肾上腺皮质癌的潜在治疗和预后靶点
Shaojin Li,Shuixiu Xiao,Yongli Situ
Shaojin Li
BackgroundApolipoprotein C1 (APOC1) and Apoprotein E (APOE) play important roles in lipid transport and metabolism. In recent years, APOC1 and APOE have been shown to play key roles in the occurrence and development of various cancers. Howe...
Serum CA19-9 as a predictor of incident metabolic syndrome in obese middle-aged and older men: A 9-year cohort study [0.03%]
肥胖中老年男性血清CA19-9作为新发代谢综合征预测因子的九年的队列研究
Chun-Wei Yu,Li-Wei Wu,Je-Ming Hu et al.
Chun-Wei Yu et al.
BackgroundThe status of carbohydrate antigen 19-9 (CA19-9) in metabolic syndrome (MetS) is unknown.ObjectiveTo investigate the association between serum CA19-9 levels and incident metabolic syndrome in obese middle-aged and older men.Method...
Estimated proportion of cancer deaths not addressed by current cancer screening efforts in the United States [0.03%]
估计出当前美国癌症筛查工作中未涉及的癌症死亡比例
Joshua J Ofman,William Dahut,Ahmedin Jemal et al.
Joshua J Ofman et al.
BackgroundIt is unclear what proportion of the population cancer burden is covered by current implementation of USPSTF A/B screening recommendations.ObjectiveWe estimated the proportion of all US cancer deaths caused by cancer types not cov...
Biomarkers in lung cancer diagnosis and bronchoscopy: Current landscape and future directions [0.03%]
肺癌诊断和支气管镜检查中的生物标志物：现状与未来方向
Nina A Thomas,Melissa L New
Nina A Thomas
Lung cancer is the leading cause of cancer death world-wide. Along the entire timeline of lung cancer identification, diagnosis and treatment, clinicians and patients face challenges in clinical decision-making that could be aided by useful...
A nomogram based on preoperative NLR predicts distant metastasis of urothelial carcinoma of the bladder [0.03%]
基于术前NLR的Nomogram预测膀胱尿路上皮癌远处转移
Xingxing Zhang,Bin Zhang,Yang He et al.
Xingxing Zhang et al.
BackgroundDistant metastasis (DM) remains the most commonly reported cause of death in patients with urothelial carcinoma of the bladder (UCB).ObjectiveWe aimed to develop a robust prognostic model to assess the risk of DM in patients with ...
Identification of the molecular subtype and prognostic characteristics of lung adenocarcinoma based on CD8+ T cell-related gene signature [0.03%]
基于CD8+T细胞相关基因特征识别肺腺癌的分子亚型和预后特性
Keke Tang,Ji Shen,Dan Liu et al.
Keke Tang et al.
BackgroundLung adenocarcinoma (LUAD) stands as a major respiratory malignancy with high mortality. With the advent of immunotherapy, new therapeutic avenues have emerged in cancer treatment.ObjectiveOur focus aimed at developing a CD8+ T ce...
A Glycolysis and gluconeogenesis-related model for breast cancer prognosis [0.03%]
与糖酵解和糖异生相关的乳腺癌预后模型
Penglu Yang,Xiong Jiao
Penglu Yang
BackgroundBreast cancer is a malignant tumor with high morbidity and mortality, which seriously endangers the health of women around the world. Biomarker-based exploration will be effective for better diagnosis, prediction and targeted ther...
Pan-cancer genetic profiles of mitotic DNA integrity checkpoint protein kinases [0.03%]
有丝分裂DNA完整检查点蛋白激酶的泛癌遗传特征
Ayana Meegol Rasteh,Hengrui Liu,Panpan Wang
Ayana Meegol Rasteh
Background: The mitotic DNA integrity checkpoint signaling pathway is potentially involved in cancers that regulate genomic stability where protein kinases play a pivotal role. 16 total protein kinase genes are involved in this pathway: ATM...
Predictive role of HPGD gene in carcinogenesis and immune environment monitoring in human cervical cancer [0.03%]
HPGD基因在人类宫颈癌的发生及免疫环境监测中的预测作用研究
Mingzhu Zhai,Weihua Yang,Chen Zou et al.
Mingzhu Zhai et al.
Background15-Hydroxyprostaglandin dehydrogenase (15-PGDH, gene symbol HPGD) is considered a tumor suppressor, and its expression is often proportional to the anticancer response. However, the clinical significance of HPGD/15-PGDH in predict...