PDGF-BB induces conversion, proliferation, migration, and collagen synthesis of oral mucosal fibroblasts through PDGFR-β/PI3K/ AKT signaling pathway [0.03%]
血小板源性生长因子BB通过PDGFR-β/PI3K/AKT信号通路诱导口腔黏膜成纤维细胞转化、增殖、迁移及促胶原合成
Jie Wang,Jialing You,Ding Gong et al.
Jie Wang et al.
Objective: To explore the pathogenesis of oral submucosal fibrosis (OSF) by analyzing the impact of Platelet Derived Growth Factor (PDGF)-BB on oral mucosal fibroblasts (FB) and PDGFR-β/Phosphoinositide 3-kinase (PI3K)/s...
Coexpression of Smac/DIABLO and Estrogen Receptor in breast cancer [0.03%]
survivin和乳腺癌组织中雌激素受体的共表达研究
Magali Espinosa,Floria Lizárraga,Karla Vázquez-Santillán et al.
Magali Espinosa et al.
Background: Smac/DIABLO is a proapoptotic protein deregulated in breast cancer, with a controversial role as a tumor marker, possibly due to a lack of correlative mRNA and protein analyses. ...
LncRNA XIST/miR-137 axis strengthens chemo-resistance and glycolysis of colorectal cancer cells by hindering transformation from PKM2 to PKM1 [0.03%]
长链非编码RNA XIST通过抑制PKM2向PKM1的转化增强结直肠癌细胞化疗耐药性及糖酵解的miR-137轴机制研究
Hailun Zheng,Mei Zhang,Xiquan Ke et al.
Hailun Zheng et al.
Background: Glycolysis was an essential driver of chemo-resistance in colorectal cancer (CRC), albeit with limited molecular explanations. Objective: ...
DEPDC1 upregulation promotes cell proliferation and predicts poor prognosis in patients with gastric cancer [0.03%]
DEPDC1表达上调通过促进胃癌细胞增殖提示不良预后
Zhaohua Gong,Hongjin Chu,Jian Chen et al.
Zhaohua Gong et al.
Background: Previous studies revealed that DEP domain containing 1 (DEPDC1) is involved in the carcinogenesis and progression of several types of human cancer. However the role of DEPDC1 in gastric cancer has not been stu...
The discriminative ability of Prostate Health Index to detect prostate cancer is enhanced in combination with miR-222-3p [0.03%]
前列腺健康指数联合miR-222-3p用于提高检测前列腺癌的鉴别能力
Angelika Tölle,Klaus Jung,Frank Friedersdorff et al.
Angelika Tölle et al.
Background: There is an urgent need for better prostate cancer (PCa) biomarkers due to the low specificity of prostate specific antigen (PSA). Objective: ...
Identification of potential serum biomarkers for simultaneously classifying lung adenocarcinoma, squamous cell carcinoma and small cell carcinoma [0.03%]
同时分类肺腺癌、鳞状细胞癌和小细胞癌的潜在血清生物标志物的识别
Jiangqing Yu,Fen Du,Liping Yang et al.
Jiangqing Yu et al.
Background: Histological subtypes of lung cancer are crucial for making treatment decisions. However, multi-subtype classifications including adenocarcinoma (AC), squamous cell carcinoma (SqCC) and small cell carcinoma (S...
Integrative analysis of transcriptional profile reveals LINC00052 as a suppressor of breast cancer cell migration [0.03%]
整合分析发现长链非编码RNA LINC00052能够抑制乳腺癌细胞转移
Jose Manuel Sanchez-Lopez,Edna Ayerim Mandujano-Tinoco,Alfredo Garcia-Venzor et al.
Jose Manuel Sanchez-Lopez et al.
Background: Long-non-coding RNAs, a class of transcripts with lengths > 200 nt, play key roles in tumour progression. Previous reports revealed that LINC00052 (long intergenic non-coding RNA 00052) was strongly downregula...
MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3 [0.03%]
microRNA-miR-3666通过靶向STAT3下调AK4在卵巢癌中起抑癌作用
Huiping Tan,Chunlin Wu,Bo Huang et al.
Huiping Tan et al.
As a result of metastasis and high recurrence, ovarian carcinoma (OC) is one of the most frequent gynecological carcinomas affecting women up to now. In spite of advances in OC treatments, the molecular mechanisms underlying OC progression ...
Upregulation lnc-NEAT1 contributes to colorectal cancer progression through sponging miR-486-5p and activating NR4A1/Wnt/β-catenin pathway [0.03%]
长链非编码RNA NEAT1通过海绵吸附miR-486-5p和激活NR4A1 / Wnt / β-catenin通路促进结直肠癌进展的作用机制研究
Zhining Liu,Yimei Gu,Xiaohu Cheng et al.
Zhining Liu et al.
Colorectal cancer is a major public health problem and fourth guiding cause of cancer-induced mortality worldwide. The five-year survival rate for patients with colorectal cancer remains poor, and almost half of colorectal cancer patients p...
Study of the co-expression gene modules of non-small cell lung cancer metastases [0.03%]
非小细胞肺癌转移的共表达基因模块研究
Guanghui Wang,Fenglong Bie,Guangxu Li et al.
Guanghui Wang et al.
Background: Metastasis regularly is a marker of the disease development of cancers. Some metastatic sites significantly showed more serious clinical outcomes in non-small cell lung cancer (NSCLC). Whether they are caused ...