Identification of novel autoantibodies in ascites of relapsed paclitaxel-resistant gastric cancer with peritoneal metastasis using immunome protein microarrays and proteomics [0.03%]
采用免疫组蛋白质微阵列和蛋白质组学鉴定腹水中的新自身抗体以治疗复发紫杉醇耐药胃癌腹膜转移患者
Zhongyin Yang,Chao Yan,Wentao Liu et al.
Zhongyin Yang et al.
Background: Gastric cancer (GC) patients with peritoneal metastasis usually have extremely poor prognosis. Intraperitoneal infusion of paclitaxel (PTX) provides an effective treatment, but relapse and PTX-resistance are u...
Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP [0.03%]
OLK和OLP恶性转化的潜在生物标志物KLK5和uPA唾液检测模型研究
Yingzhu Kang,Jiao Chen,Xiaoying Li et al.
Yingzhu Kang et al.
Background: Oral squamous cell carcinoma (OSCC) usually originates from oral potentially malignant disorders (OPMD), such as oral leukoplakia (OLK) and oral lichen planus (OLP). Identifying biomarkers for the early diagno...
Targeting IL-17alpha to promote anti-PD-1 therapy effect by screening the tumor immune microenvironment in a mouse oral carcinogenesis model [0.03%]
通过筛选小鼠口腔癌变模型中的肿瘤免疫微环境来靶向IL-17α以促进抗PD-1治疗效果
Shan Wang,Xiaorong Yu,Fang Li et al.
Shan Wang et al.
Background: Resistance to PD-1 blocking agents is not uncommon, limiting their wide clinical success. Certain tumor-infiltrating immune cells (e.g., TILs/CTLs) have emerged as biomarkers of response, and absence of such i...
The relationship between LncRNAs and lung adenocarcinoma as well as their ceRNA network [0.03%]
长链非编码RNA与肺腺癌及其ceRNA网络的关系研究
Yuxin Zhao,Shuwen Ma,Zhigang Cui et al.
Yuxin Zhao et al.
Background: More and more studies have shown that long non-coding RNA (LncRNA) as a competing endogenous RNA (ceRNA) plays an important role in lung cancer. Therefore, we analyzed the RNA expression profiles of 82 lung ca...
Exosomal microRNAs as potential biomarkers for osimertinib resistance of non-small cell lung cancer patients [0.03%]
非小细胞肺癌患者奥希替尼耐药相关的外泌体microRNA及其作用机制研究
Keatdamrong Janpipatkul,Narumol Trachu,Piyakarn Watcharenwong et al.
Keatdamrong Janpipatkul et al.
Background: Osimertinib is an epidermal growth factor receptor-tyrosine kinase inhibitor that specifically targets the T790M mutation in cancer.Unfortunately, most non-small cell lung cancer (NSCLC) patients develop osime...
Repression of protocadherin 17 is correlated with elevated angiogenesis and hypoxia markers in female patients with breast cancer [0.03%]
乳腺癌女性患者中原钙粘着蛋白17表达受到抑制与血管生成标志物及缺氧标志物升高相关
Sanaa A El-Benhawy,Samia A Ebeid,Nadia A Abd El Moneim et al.
Sanaa A El-Benhawy et al.
Background: Altered cadherin expression plays a vital role in tumorigenesis, angiogenesis and tumor progression. However, the function of protocadherin 17 (PCDH17) in breast cancer remains unclear. ...
Prognostic role of pretreatment lung immune prognostic index in extensive-stage small-cell lung cancer treated with platinum plus etoposide chemotherapy [0.03%]
铂类联合依托泊苷化疗治疗广泛期小细胞肺癌的预处理肺免疫预后指数的预后作用
Weixiang Qi,Shengguang Zhao,Jiayi Chen
Weixiang Qi
Background: To investigate the prognostic role of lung immune prognostic index (LIPI) in extensive-stage small-cell lung cancer (ES-SCLC) patients treated with platinum plus etoposide chemotherapy. ...
KCNN4 promotes the progression of lung adenocarcinoma by activating the AKT and ERK signaling pathways [0.03%]
KCNN4通过激活AKT和ERK信号通路促进肺腺癌进展
Ping Xu,Xiao Mo,Ruixue Xia et al.
Ping Xu et al.
Background: Potassium channels, encoded by more than seventy genes, are cell excitability transmembrane proteins and become evident to play essential roles in tumor biology. ...
Three plasma-based microRNAs as potent diagnostic biomarkers for endometrial cancer [0.03%]
基于血浆的三种microRNA作为子宫内膜癌有力的诊断生物标志物
Xingchen Fan,Minmin Cao,Cheng Liu et al.
Xingchen Fan et al.
Background: MicroRNAs (miRNAs), with noticeable stability and unique expression pattern in plasma of patients with various diseases, are powerful non-invasive biomarkers for cancer detection including endometrial cancer (...
PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway [0.03%]
PMEPA1通过激活JNK信号通路促进非小细胞肺癌进展
Benxu Tan,Yonghong Chen,Lei Xia et al.
Benxu Tan et al.
Background: Prostate transmembrane protein androgen-induced 1 (PMEPA1), a critical checkpoint of multiple signaling pathways, has been demonstrated to play a crucial role in various types of cancers. However, little is kn...