Association of endocan expression with clinicopathological prognostic parameters in breast carcinoma [0.03%]
乳腺癌中内皮糖蛋白endo-can的表达与临床病理预后参数的相关性分析
Zeliha Esin Celik,Fatih Demir,Harun Yonar et al.
Zeliha Esin Celik et al.
Background: Breast cancer (BC) is a common malignancy in women. Some molecules, including endocan, are still under investigation as potential prognostic factors in BC. ...
Role of Tim-3 in regulating tumorigenesis, inflammation, and antitumor immunity therapy [0.03%]
Tim-3在调节肿瘤发生、炎症及抗肿瘤免疫治疗中的作用
Yuting Cao,Qiang Li,Huihui Liu et al.
Yuting Cao et al.
Over the past decade, cancer immunotherapy, such as immune checkpoint inhibitors (ICRs), has attained considerable progresses in clinical practice. T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) act as next ICRs, and or...
Targeting PKM2 promotes chemosensitivity of breast cancer cells in vitro and in vivo [0.03%]
靶向PKM2可提高乳腺癌细胞的化疗敏感性
Yu Wang,Han Zhao,Ping Zhao et al.
Yu Wang et al.
Background: Pyruvate kinase M2 (PKM2) was overexpressed in many cancers, and high PKM2 expression was related with poor prognosis and chemoresistance. Obj...
Association between baseline Controlling Nutritional Status score and clinical outcomes of patients with multiple myeloma [0.03%]
基线营养状况评分与多发性骨髓瘤患者临床结局之间的关联研究
Xin Zhou,Yan Lu,Jun Xia et al.
Xin Zhou et al.
Background: The Controlling Nutritional Status (CONUT) score, a novel immuno-nutritional index, was reported as a predictor of overall survival (OS) in some tumors. ...
IGF-1R depletion sensitizes colon cancer cell lines to radiotherapy [0.03%]
IGF-1R的耗竭使结肠癌细胞系对放射治疗产生敏感性
Rui Zong,Xiaoman Chen,Jingjing Feng et al.
Rui Zong et al.
Purpose: Insulin like growth factor receptor 1 (IGF-1R) has been documented to play a key role in radiation response, thereby offering an attractive drug target to enhance tumor sensitivity to radiotherapy. Here, we inves...
Progressive alteration of DNA methylation of Alu, MGMT, MINT2, and TFPI2 genes in colonic mucosa during colorectal cancer development [0.03%]
结直肠癌发生过程中结肠粘膜中Alu、MGMT、MINT2和TFPI2基因DNA甲基化渐进性改变
Ben Kang,Hyun Seok Lee,Seong Woo Jeon et al.
Ben Kang et al.
Background: Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is characterized by different pathways of carcinogenesis and is a heterogeneous disease with diverse molecular l...
Evaluation of a 92 multiplex protein panel in detection of colorectal cancer and high-risk adenoma in 784 symptomatic individuals [0.03%]
评估一种多蛋白标志物检测队列在784例症状性结直肠癌和高危腺瘤患者中的诊断价值
Louise Rasmussen,Hans Jørgen Nielsen,Ib Jarle Christensen
Louise Rasmussen
Background: Blood-based protein biomarkers for detection of colorectal cancer (CRC) have been submitted to intense research to improve the full potential in screening for CRC. ...
CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells [0.03%]
CEACAM5过表达是结直肠CD133阳性癌干细胞的一个可靠特性
Alisa Gisina,Svetlana Novikova,Yan Kim et al.
Alisa Gisina et al.
Background: CD133 (prominin-1) is the most commonly used molecular marker of the cancer stem cells (CSCs) that maintain tumor progression and recurrence in colorectal cancer. However, the proteome of CSCs directly isolate...
Relevance of plasma bone marrow Activin-A and CXCL-12 concentration levels as a biomarker in acute myeloid leukemia [0.03%]
急性髓系白血病中血浆骨髓活化素-A和CXCL-12浓度水平作为生物标志物的相关性研究
Salah Aref,Lamiaa Ebrahim,Shaimaa El-Ashwah et al.
Salah Aref et al.
Background: Acute myeloid leukemia changes the bone marrow (BM) niche to support leukemia cells by modulating the stromal microenvironment. The aim is to assess Activin-A as a biomarker in acute myeloid leukemia (AML). ...
Epigenetically-regulated serum GAS5 as a potential biomarker for patients with chronic hepatitis B virus infection [0.03%]
表观遗传调控的血清GAS5作为慢性乙型肝炎病毒感染患者的潜在生物标志物
Yong Guo,Chunxue Li,Rongrong Zhang et al.
Yong Guo et al.
Background: Long non-coding RNA-growth arrest specific transcript 5 (lncRNA-GAS5) plays a suppressive role in activated hepatic stellate cells (HSCs). LncRNAs could circulate in the blood in a cell-free form and serve as ...