Systematic exploration of prognostic alternative splicing events related to tumor immune microenvironment of Clear Cell Renal Cell Carcinoma [0.03%]
系统探索透明细胞肾细胞癌肿瘤免疫微环境相关的预后可变剪接事件
Hongwei Wu,Yuchuan Zhou,Xi Wang et al.
Hongwei Wu et al.
BackgroundPathologically, clear cell renal cell carcinoma (ccRCC) is the most common type of renal carcinoma, with high heterogeneity and poor prognosis. There is increasing evidence that alternative splicing (AS) is involved in tumor evolu...
Exploring the regulatory role of CNPY3 as a prognostic biomarker on human glioma cell migration, invasion and immune infiltration [0.03%]
探索CNPY3作为胶质瘤预后生物标志物调控胶质瘤细胞迁移、侵袭及免疫浸润的作用机制
Lu Zhan,Fanyue Zeng,Jie Zheng et al.
Lu Zhan et al.
BackgroundCanopy FGF signalling regulator 3 (CNPY3) is involved in immune regulation, tumorigenesis and development, nevertheless, its role in glioma remains largely unexplored. Our study aimed to explore the regulatory role of CNPY3 as a p...
A nomogram based on the 3-gene signature and clinical characteristics for predicting lymph node metastasis in papillary thyroid cancer [0.03%]
基于三种基因特征和临床特点的甲状腺乳头状癌淋巴结转移预测图表模型
Yan Yang,Da-Song Wang,Lei Yang et al.
Yan Yang et al.
BackgroundPrecise recognition of neck lymph node metastasis (LNM) is essential for choosing the suitable scope of operation for papillary thyroid cancer(PTC) patients.ObjectiveThe purpose of our study was to establish an effective nomogram ...
From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform [0.03%]
从胰腺血液生物标志物载脂蛋白A2的发现到临床应用
Ayumi Kashiro,Giman Jung,Kazufumi Honda
Ayumi Kashiro
Pancreatic cancer is a rare and refractory cancer, and the development of blood biomarkers for the enrichment of high-risk individuals who have risk factors for pancreatic cancer from the asymptomatic population is an unmet medical need. We...
Multi-cancer early detection tests: Attributes for clinical implementation [0.03%]
多癌症早期检测测试：临床实施属性分析
Jon O Ebbert,Ernest T Hawk,Christopher V Chambers et al.
Jon O Ebbert et al.
Guideline-recommended screening programs exist for only a few single-cancer types, and these cancers represent less than one-half of all new cancer cases diagnosed each year in the U.S. In addition, these "single-cancer" standard of care (S...
Circulating tumor HPV DNA, antibodies to HPV16 early proteins, and oral HPV16 DNA as biomarkers for HPV-related oropharyngeal cancer screening [0.03%]
用于筛查HPV相关口咽癌的生物标志物：循环肿瘤HPV DNA，针对HPV16早期蛋白的抗体和口腔HPV16 DNA
Kristina R Dahlstrom,Andrew T Day,Victor M Alvarez et al.
Kristina R Dahlstrom et al.
BackgroundOropharyngeal cancer rates continue to rise with no effective screening method. Persistent oral oncogenic human papillomavirus (HPV), antibodies to HPV16 early (E) oncoproteins, and circulating tumor HPV DNA (ctHPVDNA) are biomark...
Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow [0.03%]
组织和多种癌症类型的空间蛋白质组学和转录组学特征，包括去钙化的骨髓
Cecilia Cs Yeung,Daniel C Jones,David W Woolston et al.
Cecilia Cs Yeung et al.
BackgroundRecent technologies enabling the study of spatial biology include multiple high-dimensional spatial imaging methods that have rapidly emerged with different capabilities evaluating tissues at different resolutions for different sa...
A potential target for the future treatment of malignant pleural effusion: Monocyte chemoattractant protein-1 (MCP-1) [0.03%]
恶性胸腔积液治疗的潜在靶点：单核细胞趋化蛋白-1(MCP-1)
Fatih Tekin,Deniz Koksal,Z Gunnur Dikmen et al.
Fatih Tekin et al.
Background and Aim: Malignant pleural effusion (MPE) is a common clinical problem. Management options are mainly pleurodesis and drainage, and have remained unchanged for years. Novel therapies that target the molecules responsible for flui...
A simplified MyProstateScore2.0 for high-grade prostate cancer [0.03%]
高分级前列腺癌的简化版MyProstateScore2.0
Tiffany M Tang,Yuping Zhang,Ana M Kenney et al.
Tiffany M Tang et al.
Background: The limited diagnostic accuracy of prostate-specific antigen screening for prostate cancer (PCa) has prompted innovative solutions, such as the state-of-the-art 18-gene urine test for clinically-significant PCa (MyProstateScore2...
DNA damage of peripheral blood lymphocytes as a dual biomarker: Diagnostic and treatment response in woman breast cancer patients [0.03%]
外周血淋巴细胞的DNA损伤作为双效生物标志物：女性乳腺癌患者的诊断和治疗反应
Ana Rita Guedes,Jorge Pinto Soares,Renato Cunha et al.
Ana Rita Guedes et al.
BackgroundBreast cancer is the leading malignancy among women and the lack of ideal early biomarkers hampers diagnosis and treatment monitoring. Genomic instability, central to breast cancer development, makes DNA damage a potential biomark...