Development and verification of cell cycle-related gene markers for prognosis in bladder cancer [0.03%]
膀胱癌预后相关细胞周期基因标记物的开发与验证
Hao Li,Dandan Zhu
Hao Li
BackgroundThe abnormal expression patterns of genes associated with cell cycle control are essential contributors to the initiation and progression of bladder cancer (BC).MethodsIn this research, transcriptomic profiles sourced from The Can...
Detection of methylated SEPT9 DNA in peripheral blood for diagnosis of colorectal cancer [0.03%]
检测外周血中SEPT9基因甲基化用于诊断结直肠癌
Mengjie Lin,Hong Chen,Caifeng Jiang
Mengjie Lin
BackgroundColorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Although colonoscopy is effective screening method, its widespread adoption is hampered by poor compliance. Development of patient-friendly screeni...
Bidirectional Mendelian randomization analysis reveals significant associations between Serum DNA repair proteins and liver cancer [0.03%]
双向孟德尔随机化分析发现血清DNA修复蛋白与肝癌存在显著关联
Sihao Lin,Kunpeng Fang,Li Geng
Sihao Lin
PurposeThis study investigated causal relationships and underlying mechanisms between serum DNA repair proteins and liver cancer to identify biomarkers for clinical management.MethodsA two-sample bidirectional Mendelian randomization (MR) d...
Integrative bioinformatics analysis identifies HCCS as a prognostic and therapeutic biomarker in lung cancer [0.03%]
整合生物信息学分析识别HCCS作为肺癌预后和治疗生物标志物
Sm Faysal Bellah,Md Alim Hossen,S M Saker Billah
Sm Faysal Bellah
BackgroundLung cancer remains one of the leading causes of cancer-related mortality worldwide. Holocytochrome c synthase (HCCS), a mitochondrial enzyme involved in apoptosis and energy metabolism, has been implicated in tumorigenesis; howev...
The impact of HER2 low positivity in hormone receptor-positive, HER2-negative breast cancer treated with neoadjuvant chemotherapy [0.03%]
HER2低阳性对激素受体阳性、HER2阴性乳腺癌新辅助化疗的影响
Mustafa Ersoy
Mustafa Ersoy
AimsThis study aimed to investigate whether the efficacy of neoadjuvant chemotherapy differs between HER2-low and HER2-zero subgroups in hormone receptor-positive, HER2-negative breast cancer.Materials and MethodsA total of 61 patients who ...
A panel of plasma proteins associated with venous thromboembolism in patients with prostate cancer [0.03%]
前列腺癌患者静脉血栓形成的血浆蛋白谱系分析
Asha Jose,Simon Lu,Chao Zhang et al.
Asha Jose et al.
PurposeVenous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a leading cause of morbidity and mortality in cancer patients. Prostate cancer is associated with an elevated risk of VTE, yet the molecular driv...
Serum exosomal miR-1275 as a potential biomarker for the diagnosis and prognostic assessment of hepatocellular carcinoma [0.03%]
血清外泌体miR-1275作为肝细胞癌诊断和预后评估潜在生物标志物的研究
Yang Jun,Chen Yeng,Shen Sainan et al.
Yang Jun et al.
BackgroundHepatocellular carcinoma (HCC) is a major global health burden, with limited tools for early diagnosis and prognosis. This study explores serum-derived exosomal miR-1275 as a potential non-invasive biomarker for HCC.MethodsExosome...
CD137L and colorectal cancer prognosis: Insights from clinical and TCGA data analysis [0.03%]
CD137L与结直肠癌预后的关系：来自临床和TCGA数据分析的启示
Kaiyu Xu
Kaiyu Xu
BackgroundCD137L plays a substantial role in immune regulation and has been associated with tumor progression. However, its expression pattern and clinical significance in colorectal cancer remain unclear. The current study was planned to e...
Characterization of a novel four-miRNA signature in papillary thyroid carcinoma: Integrating molecular profiling, hormonal regulation, and diagnostic implications in populations with rising PTC incidence [0.03%]
一种新型的四个microRNA标志物在乳头状甲状腺癌中的特征描述：整合分子谱型、激素调节和诊断意义以应对不断上升的PTC发病率人群
Afshan Afzal,Nafeesa Kainat,Aayesha Riaz et al.
Afshan Afzal et al.
Diagnosing papillary thyroid carcinoma (PTC) remains challenging, particularly due to limitations in fine-needle aspiration biopsy (FNAB), which yields up to 10% nondiagnostic results. The objective of this study was to evaluate the diagnos...
SLAMF8 expression and prognostic significance in melanoma: A multi-omics and Mendelian randomization study [0.03%]
SLAMF8在黑色素瘤中的表达及预后意义：一项多组学和孟德尔随机化研究
Jianjiang Liu,Wei Han,Guoliang Shen
Jianjiang Liu
BackgroundMelanoma represents one of the most aggressive skin cancers, responsible for over 75% of skin cancer-related deaths despite comprising only 5% of cases. Despite therapeutic advances, patient responses remain variable and unpredicv...