Assessing the clinical utility of biomarkers using the intervention probability curve (IPC) [0.03%]
利用干预概率曲线（IPC）评估生物标志物的临床效用
Rafael Paez,Dianna J Rowe,Stephen A Deppen et al.
Rafael Paez et al.
Background: Assessing the clinical utility of biomarkers is a critical step before clinical implementation. The reclassification of patients across clinically relevant subgroups is considered one of the best methods to es...
Upregulation of MED7 was associated with progression in hepatocellular carcinoma [0.03%]
MED7上调与肝细胞癌进展相关
Zheng-Lin Chen,Ying-Yu Ma,Xiao-Zhou Mou et al.
Zheng-Lin Chen et al.
Objective: MED subunits have been reported to be associated with various types of tumors, however, the potential role of MED7 in hepatocellular carcinoma (HCC) was still unclear. The aim of the study was to explore the ro...
Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response [0.03%]
循环miR-10b、可溶性尿激酶型纤溶酶原激活物受体和纤溶酶原激活剂抑制物-1作为非小细胞肺癌进展和治疗反应预测因素的研究
Lyana Setiawan,Rahajuningsih Setiabudy,Siti Boedina Kresno et al.
Lyana Setiawan et al.
Background: Despite advances in lung cancer treatment, most lung cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminoge...
Correlation between IL3 signaling pathway-related genes and immune checkpoint inhibitor efficacy in patients with renal cell carcinoma [0.03%]
IL3信号通路相关基因与肾细胞癌患者免疫检查点抑制剂疗效的相关性研究
Shuang Hou,Tianqi Gu,Ying Shi et al.
Shuang Hou et al.
Background: There is a lack of effective biomarkers that predict immunotherapy efficacy in clear cell renal cell carcinoma(KIRC). Objective: ...
Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model [0.03%]
皮下脂肪可预测乳腺癌骨转移：一种新型多模态深层学习模型
Shidi Miao,Haobo Jia,Wenjuan Huang et al.
Shidi Miao et al.
Objectives: This study explores a deep learning (DL) approach to predicting bone metastases in breast cancer (BC) patients using clinical information, such as the fat index, and features like Computed Tomography (CT) imag...
Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma [0.03%]
PUI元素诱导的小花睾丸（PIWI）转录物高表达模式可能是肝细胞癌潜在的候选标记物
Gehan Hammad,Samah Mamdouh,Dina Mohamed Seoudi et al.
Gehan Hammad et al.
Background: P-Element-induced wimpy testis (PIWI) proteins, when in combination with PIWI-interacting RNA (piRNA), are engaged in the epigenetic regulation of gene expression in germline cells. Different types of tumour c...
Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression [0.03%]
hsa_circ_0000018/let-7f-5p/FAM96A轴在肺腺癌进展中作用的评估
Qi Li,Min Zhao,Dan-Dan Hu et al.
Qi Li et al.
Background: Circular RNAs (circRNAs) are critical regulators of lung adenocarcinoma (LA) progression. Although a molecular marker targeting hsa_circ_0000018 has been developed and used for diagnosing colon cancer, the rol...
The identification of N6-methyladenosine-related miRNAs predictive of hepatocellular carcinoma prognosis and immunotherapy efficacy [0.03%]
用于预测肝细胞癌预后和免疫治疗效果的N6-甲基腺苷相关的miRNA的鉴定
Renrui Zou,Yaqian Liu,Sangsang Qiu et al.
Renrui Zou et al.
Background: Hepatocellular carcinoma (HCC) has a high degree of malignancy and poor prognosis. N6-methyladenosine (m6A) modifications and microRNAs (miRNAs) play pivotal roles in tumorigenesis and development. However, th...
Integrative analysis of histone acetyltransferase KAT2A in human cancer [0.03%]
人类癌症中组蛋白乙酰转移酶KAT2A的集成分析
Hua Li,Chun Li,Lu-Zong Yang et al.
Hua Li et al.
The high incidence of mutations and the crucial roles of KAT2A in cancer development have received increased attention. Nevertheless, a systematic comparison of the heterogeneity and dynamics across different cancer types has not been condu...
STEAP3 is a prognostic biomarker that promotes glioma progression by regulating immune microenvironment and PI3K-AKT pathway [0.03%]
STEAP3通过调节免疫微环境和PI3K-AKT途径促进胶质瘤进展的预后生物标志物
Zihan Song,Zijun Zhao,Siyu Zhu et al.
Zihan Song et al.
Background: STEAP3 is a metal reductase located on the plasma membrane close to the nucleus and vesicles. Despite numerous studies indicating the involvement of STEAP3 in tumor advancement, the prognostic value of STEAP3 ...