LDCT image biomarkers that matter most for the deep learning classification of indeterminate pulmonary nodules [0.03%]
用于深度学习分类的不确定肺结节的关键低剂量CT影像生物标志物
Axel H Masquelin,Nick Cheney,Raúl San José Estépar et al.
Axel H Masquelin et al.
Background: Continued improvement in deep learning methodologies has increased the rate at which deep neural networks are being evaluated for medical applications, including diagnosis of lung cancer. However, there has be...
Peripheral blood biomarkers associated with combination of immune checkpoint blockade plus chemotherapy in NSCLC [0.03%]
免疫检查点抑制剂联合化疗治疗非小细胞肺癌的外周血生物标志物研究
Nozomu Kimura,Yoko Tsukita,Risa Ebina-Shibuya et al.
Nozomu Kimura et al.
Background: Biomarkers predicting clinical outcomes of treating non-small cell lung cancer (NSCLC) with combination of immune checkpoint inhibitors (ICIs) and chemotherapy would be valuable. ...
PRDM1 rs2185379, unlike BRCA1, is not a prognostic marker in patients with advanced ovarian cancer [0.03%]
PRDM1 rs2185379与BRCA1不同，并不是晚期卵巢癌患者的预后标志物
Klara Horackova,Michal Vocka,Sarka Lopatova et al.
Klara Horackova et al.
Background: Ovarian cancer (OC) is mostly diagnosed in advanced stages with high incidence-to-mortality rate. Nevertheless, some patients achieve long-term disease-free survival. However, the prognostic markers have not b...
Cuproptosis-related gene-located DNA methylation in lower-grade glioma: Prognosis and tumor microenvironment [0.03%]
低级别胶质瘤中与铜死亡相关的基因定位DNA甲基化：预后和肿瘤微环境
Liucun Zhu,Fa Yuan,Xue Wang et al.
Liucun Zhu et al.
Cuproptosis a novel copper-dependent cell death modality, plays a crucial part in the oncogenesis, progression and prognosis of tumors. However, the relationships among DNA-methylation located in cuproptosis-related genes (CRGs), overall su...
Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma [0.03%]
circ_0049271通过靶向miR-1197/PTRF轴抑制成骨细胞瘤恶性进展
Yixin Wen,Feng Xu,Hui Zhang
Yixin Wen
Background: Circular RNAs (circRNAs) perform key regulatory functions in osteosarcoma (OS) tumorigenesis. In this study, we aimed to explore the detailed action mechanisms of circ_0049271 in OS progression. ...
Curating retrospective multimodal and longitudinal data for community cohorts at risk for lung cancer [0.03%]
肺癌高风险人群社区队列的回顾性多模态纵向数据整理
Thomas Z Li,Kaiwen Xu,Neil C Chada et al.
Thomas Z Li et al.
Background: Large community cohorts are useful for lung cancer research, allowing for the analysis of risk factors and development of predictive models. O...
GINS2 promotes the progression of human HNSCC by altering RRM2 expression [0.03%]
GINS2通过改变RRM2表达促进人类头颈部鳞癌进展
Tianxiang Wang,Luxi Qian,Pingchuan Zhang et al.
Tianxiang Wang et al.
Introduction: GINS2 exerts a carcinogenic effect in multiple human malignancies, while it is still unclear that the potential roles and underlying mechanisms of GINS2 in HNSCC. ...
Identification of a prognostic signature based on five ferroptosis-related genes for diffuse large B-cell lymphoma [0.03%]
基于五种铁死亡相关基因的弥漫性大B细胞淋巴瘤预后标志的鉴定
Wuping Li,Ruizhe Yao,Nasha Yu et al.
Wuping Li et al.
Background: Therapies for diffuse large B-cell lymphoma (DLBCL) are limited due to the diverse gene expression profiles and complicated immune microenvironments, making it an aggressive lymphoma. Beyond this, researches h...
Multi-omics comprehensive analysis reveals the predictive value of N6-methyladenosine- related genes in prognosis and immune escape of bladder cancer [0.03%]
多组学综合分析揭示N6-甲基腺苷相关基因在膀胱癌预后及免疫逃逸中的预测价值
Yang Liu,Zhongqi Pang,Jianshe Wang et al.
Yang Liu et al.
Background: N6-methyladenosine (m6A) is the most frequent RNA modification in mammals, and its role in bladder cancer (BC) remains rarely revealed. Object...
A novel disulfidptosis-related prognostic gene signature and experimental validation identify ACTN4 as a novel therapeutic target in lung adenocarcinoma [0.03%]
一种新的二硫化物酶相关的预后基因特征及实验验证鉴别出ACTN4为肺腺癌的新型治疗靶点
Kai Xie,Bin Wang,Pei Pang et al.
Kai Xie et al.
Background: Lung adenocarcinoma (LUAD) is a prevalent form of malignancy globally. Disulfidptosis is novel programmed cell death pathway based on disulfide proteins, may have a positive impact on the development of LUAD t...