Mechanism study of serum extracellular nano-vesicles miR-412-3p targeting regulation of TEAD1 in promoting malignant biological behavior of sub-centimeter lung nodules [0.03%]
血清外泌体miR-412-3p通过靶向调控TEAD1促进小肺癌恶性生物学行为的机制研究
Yuxia Deng,Nishant Patel,Shuang Ding et al.
Yuxia Deng et al.
Objective: To investigate the impact and potential mechanisms of serum extracellular nano-vesicles (sEVs) miR-412-3p released from sub-centimeter lung nodules with a diameter of ⩽ 10 mm on the malignant biological functi...
Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients [0.03%]
机器学习识别出用于早期检测慢性萎缩性胃炎患者的五联血清细胞因子谱面板
Fangmei An,Yan Ge,Wei Ye et al.
Fangmei An et al.
Background: Chronic atrophy gastritis (CAG) is a high-risk pre-cancerous lesion for gastric cancer (GC). The early and accurate detection and discrimination of CAG from benign forms of gastritis (e.g. chronic superficial ...
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab [0.03%]
纳武单抗治疗晚期肝细胞癌的疗效反应中循环肿瘤DNA（ctDNA）作为生物标志物的作用
Yehia I Mohamed,Sunyoung S Lee,Tarik Demir et al.
Yehia I Mohamed et al.
Background: Circulating tumor DNA (ctDNA) is a promising non-invasive marker for detection, diagnosis, treatment selection, and prognosis of hepatocellular carcinoma (HCC). ...
RANK in cancer-associated fibroblasts: A valuable prognostic determinant for metastasis in early-stage breast cancer patients [0.03%]
乳腺癌相关成纤维细胞中RANK蛋白：早期乳腺癌患者转移有价值的预后决定因素
María Belén Giorello,Francisco Raúl Borzone,María Florencia Mora et al.
María Belén Giorello et al.
Background: The molecular system of receptor activator of nuclear factor kappa-β (RANK) and its ligand (RANKL) plays a role in a variety of physiological and pathological processes. These encompass the regulation of bone...
Glioma stem cells remodel immunotolerant microenvironment in GBM and are associated with therapeutic advancements [0.03%]
胶质瘤干细胞重塑胶质母细胞瘤免疫耐受微环境并关联治疗进展
Xifeng Fei,Jie Wu,Haiyan Tian et al.
Xifeng Fei et al.
Glioma is the most common primary tumor of the central nervous system (CNS). Glioblastoma (GBM) is incurable with current treatment strategies. Additionally, the treatment of recurrent GBM (rGBM) is often referred to as terminal treatment, ...
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma [0.03%]
低级别胶质瘤中DNA甲基化调控的WEE1的鉴定及其在预后和免疫治疗中的潜在作用
Wang-Jing Zhong,Li-Zhen Zhang,Feng Yue et al.
Wang-Jing Zhong et al.
Background: WEE1 is a critical kinase in the DNA damage response pathway and has been shown to be effective in treating serous uterine cancer. However, its role in gliomas, specifically low-grade glioma (LGG), remains unc...
EMP3: A promising biomarker for tumor prognosis and targeted cancer therapy [0.03%]
EMP3：一种有前景的肿瘤预后和靶向癌症治疗生物标志物
Wenjing Zhu,Shu Song,Yangchun Xu et al.
Wenjing Zhu et al.
Epithelial membrane protein 3 (EMP3) belongs to the peripheral myelin protein 22 kDa (PMP22) gene family, characterized by four transmembrane domains and widespread expression across various human tissues and organs. Other members of the PM...
Identification of a novel necroptosis-related LncRNA signature for prognostic prediction and immune response in oral squamous cell carcinoma [0.03%]
口腔鳞状细胞癌中用于预后预测和免疫反应的新型坏死性凋亡相关长链非编码RNA标志物识别
Lanting Ji,Shuang Liang,Yahsin Cheng et al.
Lanting Ji et al.
Background: Necroptosis is a caspase-independent regulated necrotic cell death modality that elicits strong adaptive immune responses, and has the potential to activate antitumor immunity. Long non-coding RNAs (lncRNAs) h...
The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development [0.03%]
转化生长因子-β在控制口腔鳞状细胞癌发生中的悖论作用
Ruiting Peng,Yun Huang,Ping Huang et al.
Ruiting Peng et al.
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that plays a vital role in regulating cell growth, differentiation and survival in various tissues. It participates in a variety of cellular processes, including cell apop...
Glutaminase 1 plays critical roles in myelodysplastic syndrome and acute myeloid leukemia cells [0.03%]
谷氨酰胺酶1在骨髓增生异常综合征和急性髓系白血病细胞中起关键作用
Seiichi Okabe,Mitsuru Moriyama,Yuya Arai et al.
Seiichi Okabe et al.
Background: Myelodysplastic syndrome (MDS) features bone marrow failure and a heightened risk of evolving into acute myeloid leukemia (AML), increasing with age and reducing overall survival. Given the unfavorable outcome...