A causal association between Epstein-Barr virus infection and lung cancer: A two-sample Mendelian Randomization study [0.03%]
EB病毒与肺癌的因果关系：两样本孟德尔随机化研究
Jia Wang,Kai Wang,Zhishang Wang
Jia Wang
BackgroundThe association between Epstein-Barr virus (EBV) and lung cancer risk remains controversial. Here, we used a two-sample Mendelian randomization (MR) analysis to test the causal relationship between EBV and lung cancer.MethodsData ...
In silico analysis suggests ELL2 as a survival-associated cross-tissue biomarker in gastric cancer [0.03%]
基于计算的分析表明ELL2是胃癌中的一个与生存相关的跨组织生物标志物
Kiarash Zare,Zahra Salehi,Ali Reza Morovat et al.
Kiarash Zare et al.
BackgroundThe main aim of this study is to identify prognostic biomarkers through integrating bioinformatics analysis in gastric cancer, which is a significant global health challenge.MethodsGene expression datasets related to blood, tissue...
The clinical assessment of miR-34a and miR-135b panel as promising diagnostic biomarkers predict the risk of colorectal cancer: A case-control study [0.03%]
临床评估miR-34a和miR-135b作为有潜力的诊断生物标志物预测结直肠癌发病风险：一项病例对照研究
Roya Karami,Elaheh Najafi,Anahita Babaei et al.
Roya Karami et al.
BackgroundmiRNAs are of interest due to have been involved in cancers such as colorectal cancer (CRC).ObjectiveTo explore the expression levels of miRNA-34a and miRNA-135b and whether they can be potential biomarker for early diagnosis of C...
Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair-related genes with oral cancer [0.03%]
基于孟德尔随机化的整合多组学分析鉴定出DNA修复相关基因与口腔癌的关联
Jingbo Wang,Weiqing Tang,Weilong Ding et al.
Jingbo Wang et al.
BackgroundThis study aimed to identify DNA repair-related genes causally affecting OCC risk by integrating multi-omics data using summary data-based Mendelian randomization (SMR).MethodsSMR analyses were performed using GWAS, mQTL, eQTL, an...
Stage-specific biomarkers in triple-negative breast cancer: Preliminary findings from bioinformatics approaches [0.03%]
基于生物信息学方法的三阴性乳腺癌阶段特异性标志物的初步研究发现
Faeze Shahraki,Azadeh Meshkini,Elham Nazari
Faeze Shahraki
BackgroundIntegrated bioinformatics approaches were used to identify stage-specific candidate genes and potential drug targets in triple-negative breast cancer (TNBC).MethodsMicroarray (164 early-stage, 33 advanced-stage, and 53 normal samp...
Development and verification of cell cycle-related gene markers for prognosis in bladder cancer [0.03%]
膀胱癌预后相关细胞周期基因标记物的开发与验证
Hao Li,Dandan Zhu
Hao Li
BackgroundThe abnormal expression patterns of genes associated with cell cycle control are essential contributors to the initiation and progression of bladder cancer (BC).MethodsIn this research, transcriptomic profiles sourced from The Can...
Detection of methylated SEPT9 DNA in peripheral blood for diagnosis of colorectal cancer [0.03%]
检测外周血中SEPT9基因甲基化用于诊断结直肠癌
Mengjie Lin,Hong Chen,Caifeng Jiang
Mengjie Lin
BackgroundColorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Although colonoscopy is effective screening method, its widespread adoption is hampered by poor compliance. Development of patient-friendly screeni...
Bidirectional Mendelian randomization analysis reveals significant associations between Serum DNA repair proteins and liver cancer [0.03%]
双向孟德尔随机化分析发现血清DNA修复蛋白与肝癌存在显著关联
Sihao Lin,Kunpeng Fang,Li Geng
Sihao Lin
PurposeThis study investigated causal relationships and underlying mechanisms between serum DNA repair proteins and liver cancer to identify biomarkers for clinical management.MethodsA two-sample bidirectional Mendelian randomization (MR) d...
Integrative bioinformatics analysis identifies HCCS as a prognostic and therapeutic biomarker in lung cancer [0.03%]
整合生物信息学分析识别HCCS作为肺癌预后和治疗生物标志物
Sm Faysal Bellah,Md Alim Hossen,S M Saker Billah
Sm Faysal Bellah
BackgroundLung cancer remains one of the leading causes of cancer-related mortality worldwide. Holocytochrome c synthase (HCCS), a mitochondrial enzyme involved in apoptosis and energy metabolism, has been implicated in tumorigenesis; howev...
The impact of HER2 low positivity in hormone receptor-positive, HER2-negative breast cancer treated with neoadjuvant chemotherapy [0.03%]
HER2低阳性对激素受体阳性、HER2阴性乳腺癌新辅助化疗的影响
Mustafa Ersoy
Mustafa Ersoy
AimsThis study aimed to investigate whether the efficacy of neoadjuvant chemotherapy differs between HER2-low and HER2-zero subgroups in hormone receptor-positive, HER2-negative breast cancer.Materials and MethodsA total of 61 patients who ...