Mechanism-Based Allosteric Inhibition of PTP1B by Prenylated Flavonoids from Glycyrrhiza echinata: In Vitro Experiments and in Silico Validation [0.03%]
甘草酸预芳基黄酮类化合物基于机制的PTP1B异构抑制作用：体外实验及计算机模拟验证
Emadeldin M Kamel,Doaa A Abdelrheem,Noha A Ahmed et al.
Emadeldin M Kamel et al.
A phytochemical investigation of Glycyrrhiza echinata led to the isolation and structural characterization of twelve phenolic compounds. An in silico target fishing analysis identified protein tyrosine phosphatase 1B (PTP1B) as a potential ...
Functional Activities of Cohesin Proteins Can Be Altered by Chemical Chaperones [0.03%]
化学分子可改变粘连素蛋白的活性
Sayali Marathe,Haripriya Chougule,Vandana Nikam et al.
Sayali Marathe et al.
The cohesin protein complex plays a very important role in chromosome segregation, transcription, DNA replication and chromosome condensation. Mutations in cohesin proteins give rise to a disease collectively referred to as Cohesinopathies....
Delineation of Recombinant Cestode Phosphoenolpyruvate Carboxykinase Activity Co-expressed with Molecular Chaperones [0.03%]
分子伴侣共表达的复雌吸虫磷酸烯醇式丙酮酸羧基酶活性的动力学研究
Joplin Nongkhlaw,Superior Syngkli,Miranda Moirangthem et al.
Joplin Nongkhlaw et al.
Phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) of cestodes is considered a possible anthelmintic target because of its differential role in their hosts. In an earlier study, the recombinant PEPCK from Raillietina echinobothrida (reP...
Fluorescence Spectroscopy Reveals Resveratrol Binding to a Hydrophobic Pocket in Leishmania amazonensis Sir2-Related Protein 1 (LaSir2RP1) [0.03%]
荧光光谱揭示白杨素与亚马逊利什曼原虫sir2相关蛋白1型（LaSir2RP1）疏水袋的结合现象
Melissa R Fessel,Ana P R Povinelli,Veronica S Fontes et al.
Melissa R Fessel et al.
Resveratrol, a natural phytoalexin synthesized by certain plants in response to injury, exhibits antimicrobial properties and various medically significant effects, including anticancer and antiaging activities. Although its exact mechanism...
Shuchen Pei,Shusheng Liu,Jihong Luo et al.
Shuchen Pei et al.
Insulin lispro, a fast-acting insulin analogue, is widely used for the treatment of diabetes due to its rapid onset and high flexibility. This study established a three-step chromatography purification process, L fermentation broth can obta...
Correction: From Crude Extracts to Purity: A Comparative Study of Butyrylcholinesterase Purification [0.03%]
订正：从粗提物到纯化：丁酰胆碱酯酶纯化比较研究
Gamze Sonmez,Bahattin Enes Karatas,Ebru Bodur
Gamze Sonmez
Published Erratum
The protein journal. 2025 Jun 14. DOI:10.1007/s10930-025-10274-9 2025
Purification and Characterization of a New Phytolectin Extracted from Eucalyptus vicina Fruits with Immunomodulatory Effect [0.03%]
一种具免疫调节活性的新白千层果实凝集素的纯化与特性分析
Sana Boufeker,Ahlem Bahi,Imene Torche et al.
Sana Boufeker et al.
Plant-derived lectins are getting growing interest for their potential biomedical applications, however, there are few studies on lectins from Eucalyptus vicina fruits. The aim of the current study was to isolate and characterize a new phyt...
Identification of Potential RNAi Targets for Cotton Mealybug (Phenacoccus solenopsis Tinsley) Management [0.03%]
棉蚜(RNAi)潜在靶基因的鉴定
Sanchita Singh,Somnath Rahangdale,Shivali Pandita et al.
Sanchita Singh et al.
Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae), commonly known as the cotton mealybug, is a highly invasive pest worldwide, particularly in tropical and subtropical regions. Despite posing a significant economic threat to variou...
Expression and Purification of Human Stem Cell Factor and Its Effect on the Growth of A549 Cells [0.03%]
人源干细胞因子的表达纯化及其对A549细胞生长的影响
Zhenling Ma,Xulu Han,Yiyang Zhu et al.
Zhenling Ma et al.
Stem cell factor (SCF) is a type of hematopoietic cytokine that functions in early hematopoietic stem cells. SCF, together with its cognate receptor c-kit, plays crucial roles in cell survival, proliferation, and differentiation. A dysregul...
Novel Self-Cleaving Affinity Purification Method for Cellular Membrane-Associated Recombinant Paraoxonase-1 (rePON1) Enzyme [0.03%]
用于细胞膜相关重组寄主衍生的卵磷脂胆固醇酰基转移酶的新型自切割亲和纯化方法
Milton S Gonzalez-Serrano,Shuhan Chen,Alicia K Friedman et al.
Milton S Gonzalez-Serrano et al.
Mammalian paraoxonase-1 (PON1) is a ~ 39.45 kDa calcium-dependent hydrolytic enzyme with potential therapeutic applications in chemical defense and cardiovascular disease. The N-terminus of PON1 is embedded in the cellular membrane, imparti...