Design and Verification Process of a Structure-Altering Peptide as a Microtubule Allosteric Polypeptide Against Cancer [0.03%]
一种结构重塑肽作为抗肿瘤微管变构多肽的设计与验证过程研究
Zhan Shi
Zhan Shi
The aim of this study was to design a novel structure-altering polypeptide (SAP) as an anti-microtubule against tumor cells. This series of SAP XA1-XA17 was synthesized by manual solid-phase synthesis and verified by high-performance liquid...
Structural Changes of Apolipoprotein A-I Caused by Hydroxyethyl Starch 130/0.4 Reveals Potential Toxic Mechanisms [0.03%]
羟乙基淀粉130/0.4引起载脂蛋白A-I结构改变的毒性机制研究
Lingyan Qu,Liqun Jia,Jianzhong Zhang et al.
Lingyan Qu et al.
6% hydroxyethyl starch (HES 130/0.4) is frequently employed to address hypovolemia, ensuring sufficient organ perfusion and oxygen transport. The effects on Apolipoprotein A-I (ApoA-I) were examined at three temperatures-280, 295, and 310 K...
Decoding ATXN2 Phosphocode: Structural Insights and Therapeutic Opportunities in Disease [0.03%]
解码ATXN2磷酸化密码：疾病中的结构见解和治疗机会
Apoorva Pai Kalasa Anil Kumar,Suhail Subair,Prathik Basthikoppa Shivamurthy et al.
Apoorva Pai Kalasa Anil Kumar et al.
Ataxin-2 (ATXN2), a key RNA-binding protein, regulates RNA metabolism, stress granule formation, and neuronal homeostasis, with dysregulated phosphorylation contributing to Spinocerebellar Ataxia type 2 (SCA2), amyotrophic lateral sclerosis...
Characterization and Evolutionary Study of Fungal Nitrate Reductase Through Bioinformatics and Partial Gene Amplification from Aspergillus niger PKA16 employing Degenerate Primers [0.03%]
基于生物信息学和退化引物的基因扩增的产黑曲霉PKA16硝酸盐还原酶的性质及进化研究
Amrita Banerjee,Milan Kumar Samanta,Mehak Kanwar et al.
Amrita Banerjee et al.
Nitrate contamination in water sources creates major health risks that primarily affect infants by causing methemoglobinemia ("blue baby syndrome") while also leading to congenital defects and cancer development. The human body absorbs nitr...
Revealing the Bacterial HslV Protease Activation Potential with Triazine Derivatives via Experimental and Computational Approaches [0.03%]
通过实验和计算方法揭示三嗪衍生物激活细菌HslV蛋白酶的潜力
Sana Aurangzeb,Muhammad Aurongzeb,Mehwish Hamid et al.
Sana Aurangzeb et al.
The bacterial HslVU enzyme complex consists of two components: the HslV protease and the HslU ATPase. This complex share both structural and sequence similarities with the eukaryotic proteasome. HslV becomes functionally active upon engagem...
Effect of Mutations on the Evolution of Extended Spectrum β-lactamases (ESBL) [0.03%]
突变对扩展谱β-内酰胺酶(ESBL)进化的影响分析
Anirudha Dutta,Antarika Chowdhury,Parijat Roy et al.
Anirudha Dutta et al.
Bacterial antimicrobial resistance is a great public health threat worldwide, a situation that is much escalated by the rapid propagation of Extended Spectrum β-lactamase (ESBL) enzymes. These can hydrolyze and inactivate a broad range of ...
Unveiling the Immunostimulatory Potential of the HSPA1A Mini-Chaperones Compared to the HSPA1A and HSP27 Chaperones: In Silico and In Vitro Insights for Vaccine Development [0.03%]
基于疫苗开发的计算和实验研究：HSPA1A微型分子 chaperone与HSPA1A和HSP27分子 chaperones免疫刺激潜力的比较分析
Fatemeh Heidarnejad,Fateme Ekhlasi,Parisa Moradi Pordanjani et al.
Fatemeh Heidarnejad et al.
Molecular chaperones known as heat shock proteins (HSPs) are evolutionarily conserved and are critical in regulating immune system functions. To assess the immunostimulatory potential of HSPs, we employed advanced computational and experime...
Characterization of S-homocysteinylation of Human Insulin and Its Implications in Diabetes [0.03%]
人类胰岛素S-同型半胱氨酸化的特征及其在糖尿病中的意义
Amreen B Sheikh,Swaraj M Jathar,Vaishnavi Tammara et al.
Amreen B Sheikh et al.
Homocysteine thiolactone is a reactive thiol known for its interaction with various proteins. Nevertheless, there exists a paucity of information concerning the interaction between homocysteine thiolactone and human insulin, particularly re...
Comparative Characterization of Plasmodium falciparum Small Heat Shock Proteins and Their Inhibition by Quercetin (3,3',4',5,7-Pentahydroxyflavone) [0.03%]
檞皮素（3，3'，4'，5，7-五羟基黄酮）对恶性疟原虫小热休克蛋白的抑制作用及相互比较研究
Francisca Magum Timothy,Tawanda Zininga
Francisca Magum Timothy
Plasmodium falciparum, the parasite responsible for the most severe form of malaria, encodes three small heat shock proteins (sHsps), PfHsp20a, PfHsp20b, and PfHsp20c, each containing a conserved α-crystallin domain (ACD). These class I sH...
A Novel C-Terminal Small Tail Provides Thermostability of FeSOD Implying a New Mechanism of Protein Heat Resistance [0.03%]
一种新颖的C端小尾巴能提供FeSOD的耐热性并暗示了一种新的蛋白质耐热机制
Weina Lu,Zhuo Jiang,Qi Lin et al.
Weina Lu et al.
Superoxide dismutase (SOD) is found in a variety of organisms, including animals, plants, and microorganisms, and is widely used in medicine, food, and cosmetics. In this study, a novel heat-resistant SOD from Rhodothermus sp. XMH10 (RhSOD)...