Structure, Mutation, Functional Domain Roles and Medical Implications of Glycerol Kinase [0.03%]
甘油激酶的结构、突变、功能区作用及其医学意义
Emmanuel Oluwadare Balogun,Israel Ogwuche Ogra,Uche Samuel Ndidi et al.
Emmanuel Oluwadare Balogun et al.
Glycerol kinase (GK) is a key part of glycerol metabolism. It connects the metabolic pathways for lipids and carbohydrates by phosphorylating glycerol to glycerol-3-phosphate in an ATP-dependent reaction. This is essential for maintaining c...
SARS-CoV-2 Spike Protein S2 Subunit: Recombinant Protein Expression Analysis, Purification, and Its Regulatory Effect on IGF-1R Expression [0.03%]
SARS-CoV-2刺突蛋白S2亚基：重组蛋白表达分析、纯化及其对IGF-1R表达的调控作用
Ekta Singh,Rajnish Kumar,Nishita Nishi et al.
Ekta Singh et al.
SARS-CoV-2 consists of the spike (S) protein which plays an important role in mediating the entry of virus into the host and it mainly consists of two subunits which are functionally different from each other. The first subunit S1, is invol...
Biophysical Characterization of an Engineered CD80 Variant for CTLA-4 Blockade in Cancer Immunotherapy [0.03%]
癌症免疫治疗中工程改造的CD80变异型表征及其阻断CTLA-4的作用机制
Zahra Hajihassan,Amir Hossein Mosayebi,Ramezan Ali Taheri et al.
Zahra Hajihassan et al.
Production Enhancement of Surface-Expressed D-hydantoinase and D-carbamoylase in E. Coli by Developing a Novel Coculture Process for the Efficient Biotransformation of D-p-hydroxyphenylglycine [0.03%]
通过开发新型共培养过程高效生物转化D-对羟基苯甘氨酸增强表面表达D-水杨酶和D-碳酰胺酶的产量
Fatemeh Poureini,Valiollah Babaeipour,Rasoul Khalilzadeh et al.
Fatemeh Poureini et al.
D-p-hydroxyphenyl glycine (D-PHPG) is a D-amino acid used as an intermediate in the synthesis of semi-synthetic antibiotics. It is synthesized from hydantoin derivatives through two sequential enzymatic reactions involving D-hydantoinase (D...
Bruce E Bursten,Lawrence J Berliner
Bruce E Bursten
Halved but Potent: Exploring the Inhibitory Property of Curcumin Derivatives Against Evolving SARS-CoV-2 Strains [0.03%]
半量却强力：姜黄素衍生物抑制新兴SARS-CoV-2毒株的探究
Atala Bihari Jena,Umesh Chandra Dash,Asim K Duttaroy
Atala Bihari Jena
Expression and Purification of p70 (∆NH2-146/∆CT104) S6 K, a 57.3 kDa N- and C-Terminal Truncated p70S6 Kinase-GST Fusion Protein in Bacterial Expression System [0.03%]
表达及纯化不含N端146氨基酸和C端104氨基酸的p70(S6K) GST融合蛋白（分子量57.3KD）细菌表达体系研究
Shafat A Latoo
Shafat A Latoo
An essential modulator of cell growth and division is the evolutionarily conserved kinase (S6K1). It is triggered by certain stimulants, including amino acids, insulin, and other growth hormones. The Akt/phosphatidylinositol 3-kinase pathwa...
Advantages and Limitations of AlphaFold in Structural Biology: Insights from Recent Studies [0.03%]
AlphaFold在结构生物学中的优势与局限性：近期研究的启示
Mandarina Qing Cheng Li,Sihan Wang,Shi-Ruei Lin et al.
Mandarina Qing Cheng Li et al.
Over the past three years, AlphaFold-a deep learning-based protein structure prediction system-has transformed structural biology by providing near-experimental accuracy models directly from amino acid sequences. This narrative review synth...
Peptide and Protein Tags for the Half-Life Extension of Therapeutic Agents: A Review Article [0.03%]
用于药物长效化的多肽和蛋白标签：综述文章
Sorour Aboutalebi,Fatemeh Najafi,Negin Yazdizadeh et al.
Sorour Aboutalebi et al.
Although biological drugs have been considered as one of the effective and growing therapeutic approaches in the pharmaceutical industry in recent decades, the largest concern about them is the insufficient stability and rapid degradation i...
Evaluating the Structural Stability of Recombinant Rotavirus Capsid Protein VP6 in Altered Physicochemical States Using Fluorescence and CD Spectroscopy [0.03%]
基于荧光和圆二色谱技术评价轮状病毒衣壳蛋白VP6重组体系在不同物化状态下结构稳定性
Modibedi Lesego Gladys,Preenan Pillay
Modibedi Lesego Gladys
Rotaviruses (RV) are a major cause of severe childhood diarrhoea, particularly in developing nations, necessitating stable vaccines. Therefore, the presented preliminary study aimed to assess the impact of altered physicochemical properties...