Network Pharmacology and Molecular Docking to Explore the Mechanism of Compound Qilian Tablets in Treating Diabetic Retinopathy [0.03%]
网络药理学和分子对接探讨祁连丸治疗糖尿病视网膜病变的作用机制研究
Jiangwei Jia,Bo Liu,Xin Wang et al.
Jiangwei Jia et al.
Background: Diabetic Retinopathy (DR) is one of the common chronic complications of diabetes mellitus, which has developed into the leading cause of irreversible visual impairment in adults worldwide. The Compound Qilian ...
Mario Cano
Mario Cano
Validation of the Mechanism of Action of Jiedu Shengji Oil in the Treatment of Radiation Dermatitis based on Network Pharmacology and In Vivo Experiments [0.03%]
基于网络药理学和体内实验验证解毒生肌油治疗放射性皮炎的作用机制有效性研究
Weishan He,Guangmei Deng,Wenya Liu et al.
Weishan He et al.
Background: Radiation Dermatitis (RD) is a common complication of radiation therapy, with approximately 90% of patients experiencing moderate to severe radiation dermatitis injury after radiotherapy. Jiedu Shengji oil (JD...
Screening of the Prodiginine Molecules as BH3-Mimetics against the Developed Bcl-2 Antiapoptotic Chemotherapeutic Resistance: A Molecular Docking and ADMET Study Supported by Molecular Dynamics Simulations [0.03%]
基于分子对接和ADMET研究并结合分子动力学模拟筛选针对Bcl-2抗凋亡化疗耐药性开发的BH3模体的小扁桃花色素分子
Ayoub El Abbassi,Salaheddine Redouane,Zineb Azoubi et al.
Ayoub El Abbassi et al.
Background: Chemotherapy remains a primary treatment for stopping cancer cell growth. Unfortunately, resistance to chemotherapy is a challenge that leads to cancer relapse. Overexpression of the antiapoptotic proteins is ...
In Silico Identification of 2,4-Diaryl-6-styrylpyridine Derivatives as Orthosteric-Allosteric EGFR Inhibitors [0.03%]
基于计算的鉴定2,4-二芳基-6-烯丙基吡啶衍生物为表皮生长因子受体双机制抑制剂
Harizal -,Jumina -,Harno Dwi Pranowo et al.
Harizal - et al.
Background: Epidermal growth factor receptor tyrosine kinase [EGFR TK] is a primary target for inhibiting cellular signal transduction in several types of cancer. Numerous EGFR TK inhibitors have been developed and approv...
The Active Ingredients and Mechanisms of Xuefuzhuyu Pills in Treating Hyperprolactinemia Caused by Antipsychotics based on UHPLCQ-TOF-MS/MS, Network Pharmacology, and Molecular Docking Validation [0.03%]
基于UHPLCQ-TOF-MS/MS、网络药理学及分子对接验证的血复止瘀丸治疗抗精神病药物所致高催乳素血症的有效成分与机制研究
Linliu Du,Zihuan Zhang,Mingyue Liu et al.
Linliu Du et al.
Background: XueFuZhuYu pills (XFZY), a traditional Chinese herbal formula originated from the xuefuzhuyu decoction in Correction on Errors in Medical Classics, has a certain clinical effect on the treatment of hyperprolac...
Targeting the Ubiquitin-conjugating Enzyme for Oral Squamous Cell Carcinoma Therapy: Discovering Natural Inhibitors [0.03%]
靶向泛素结合酶的口腔鳞状细胞癌治疗：发现天然抑制剂
Unnati Soni,Pritish Kumar Varadwaj,Krishna Misra
Unnati Soni
Background: Oral Squamous Cell Carcinoma (OSCC) is a multiple-phase carcinogenic disease that concurrently involves malignant lesions, invasion, and metastasis. It has been reported that Ubiquitin-conjugating enzymes play...
Cholinesterase Inhibition and Anticancer Properties of [4-(Benzyloxy) phenyl]{Methylidene}hydrazinylidene]-1,3-dihydro-2H-Indol-2-ones Using Swiss Target-guided Prediction [0.03%]
[4-(苄氧基)苯基]甲ylene)-1,3-二氢-2H-吲哚-2-酮的乙酰胆碱酯酶抑制和抗癌性质及Swiss target guided预测方法研究
Naseer Maliyakkal,Parham Taslimi,Burak Tuzun et al.
Naseer Maliyakkal et al.
Introduction: Our group previously reported isatin-based hydrazones (ISB1-ISB6) were further evaluated for their in vitro acetylcholine esterase, butylcholinestrase and cytotoxic effects on cancer cell lines. The compound...
Prediction Factors for Quality Risks in the Pharmaceutical Development of Tablets Bisoprolol Fumarate with Indapamide [0.03%]
富马酸比索洛尔与吲达帕胺片药品开发质量风险预测因素探究
Nadia Malanchuk,Mariana Demchuk,Andriy Sverstiuk et al.
Nadia Malanchuk et al.
Background: An important characteristic of the quality-by-design approach is defining risk, which is a combination of the probability of harm and its severity. During risk assessment, it is essential to determine how the ...
Discovery of Polyphenolic Compounds from Mangifera indica as Potent Therapeutics for Strongyloides stercoralis Infection via Computer-aided Drug Design [0.03%]
芒果中多酚类化合物作为治疗丝虫感染的潜在药物的计算机辅助药物设计发现
Samson Olusegun Afolabi,Abel Kolawole Oyebamiji,Omowumi Temitayo Akinola et al.
Samson Olusegun Afolabi et al.
Background: The global spread of Strongyloides stercoralis has escalated public health concerns, affecting over 600 million people worldwide. The rise in global migration has heightened the risk of transmission, underscor...