Elucidating the Activity of E-Lian Granule in Alleviating Chronic Atrophic Gastritis: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation [0.03%]
基于网络药理学、分子对接及实验验证阐明愈连颗粒治疗慢性萎缩性胃炎作用机制
Yini Tang,Yan Xue,Shigui Xue et al.
Yini Tang et al.
Introduction: Chronic Atrophic Gastritis (CAG) and Intestinal Metaplasia (IM) are critical precancerous lesions of gastric cancer. E-Lian granule (ELKL), a traditional Chinese medicine formula, has demonstrated favorable ...
Elucidating the Potential Therapeutic Role of Gut Microbiota Metabolites in Atrial Fibrillation Through Network Pharmacology Combined with Target Omics [0.03%]
基于网络药理学结合靶向组学阐明肠道微生态环境代谢产物在房颤治疗中的潜在作用机制
Yi Ning,Yanglulu Su,Guoqiang Zhong
Yi Ning
Introduction: Atrial Fibrillation (AF) is a prevalent arrhythmia with complex pathogenesis and limited optimal treatments. This study aims to explore the possible protective effects of gut microbiota metabolites against A...
Network Pharmacology-guided Target Evaluation of Nefopam for Alzheimer's Disease: Insights from Docking and Molecular Dynamics Simulations [0.03%]
基于网络药理学的奈弗帕姆治疗阿尔茨海默病靶点评估：分子对接及分子动力学模拟新见解
Mayank Saini,Tanuj Hooda,Mohammad Ovais Dar et al.
Mayank Saini et al.
Introduction: Amyloid-β accumulation, aberrant tau protein, neuroinflammation, and oxidative stress are some of the main pathogenic characteristics of Alzheimer's disease (AD), a degenerative illness characterized by cog...
Exploring Omeprazole Effect on Pro-apoptotic Factors in Colorectal Cancer Treatment: Insights from In Silico Studies and Antiproliferative Assessment on HT29 Cells [0.03%]
奥美拉唑对结直肠癌治疗中促凋亡因素的影响：来自计算机模拟研究和HT29细胞抗增殖评估的见解
Tooba Abdizadeh,Sana Banisakin,Keyhan Ghatreh Samani et al.
Tooba Abdizadeh et al.
Background: Colorectal Cancer (CRC) is one of the most common cancers worldwide. There is an urgent need to identify new drugs for CRC treatment. The apoptotic factors Bad, Bid, Bik, Bim, Bax, and Bak play a crucial role ...
Precision Network Pharmacology Revealed by High-throughput Blind Docking: Deciphering the Multitarget Synergy of Taohe Chengqi Decoction against Constipation [0.03%]
高通量盲打分分子对接揭示的精准网络药理学：桃核承气汤治疗便秘多靶点配伍机制研究
Xiaoli Chang,Linbing Yu,Xudong Wu et al.
Xiaoli Chang et al.
Introduction: Constipation, prevalent globally (16-35%), is particularly common in the elderly, reducing quality of life and causing complications like intestinal obstruction. Current treatments (e.g., methylcellulose, po...
Identification of Novel PKC Alpha Inhibitors: Structural and Functional Characterization Using In Silico and In Vitro Studies [0.03%]
基于计算机和体外实验的新型PKCα抑制剂的结构与功能研究
Shiven Das,Devika S Kumar,Arunasree Kalle
Shiven Das
Introduction: Protein Kinase C alpha (PKCα), a key regulator of cellular signaling, is frequently dysregulated in breast cancer. Despite its clinical relevance, there is a dearth of selective and safe PKCα inhibitors. T...
Integrated Analysis to Identify the Roles of NAV2 in Liver Fibrosis and Atrial Fibrillation [0.03%]
整合分析鉴定NAV2在肝纤维化和房颤中的作用
Mingjie Gao,Jiahui Wang,Liang Liang et al.
Mingjie Gao et al.
Background: Although there is substantial clinical comorbidity between atrial fibrillation and liver fibrosis, it is still unknown what molecular processes these conditions share. ...
Bioactive Compounds and Mechanistic Insights of Chuanxiong Rhizoma and Angelicae Sinensis Radix in Endometriosis Treatment: A Network Pharmacology and Experimental Validation Study [0.03%]
川芎与当归治疗子宫内膜异位症的活性成分及作用机制：网络药理学和实验验证研究
Shanshan Gao,Panpan Zhao,Ke Li et al.
Shanshan Gao et al.
Introduction: Endometriosis, a chronic gynecological disorder, significantly impacts fertility and quality of life. Identifying effective therapeutic targets is critical for their management. ...
Identification of Potential Compounds from Medicinal Plants using Molecular Docking and Molecular Dynamics Simulation with Special Reference to Autism Spectrum Disorder [0.03%]
基于分子对接和分子动力学模拟的中药筛选及其自闭症网络机制研究
Anglina Kisku,Paranthaman Subash,Ambresh Nishad et al.
Anglina Kisku et al.
Introduction/objective: Autism spectrum disorder (ASD) aetiology is a multifactorial concept, involving genetic susceptibility as well as environmental and neuroinflammatory mechanisms. In this context, the present study ...
Molecular Docking, Molecular Dynamics Simulation, DFT, and ADMET Prediction of 3-Carbonyl-3-Hydroxyl-Isoindolin-1-ones, Revealing Potential Inhibitors of MAO-B [0.03%]
分子对接、分子动力学模拟、DFT及ADMET预测研究3-羰基-3-羟基异吲哚啉-1-酮类化合物：发现MAO-B抑制剂的潜在候选物
Kunal Madaan,Ram Singh
Kunal Madaan
Introduction: Parkinson's Disease (PD) is the most common neurodegenerative disease worldwide. Monoamine Oxidase B (MAO-B), which is associated with oxidative stress, is a suitable target for PD treatment. This study aime...