A Pharmacoinformatics and Molecular Dynamics Approach to the Phytochemical Screening of Ficus hispida Fruits for Prostate Cancer Therapy [0.03%]
基于药理信息学和分子动力学的Ficus hispida果实化合物筛选及其抗前列腺癌活性研究
Hasanur Rahman,Ataur Rahman,Sarwar Zahan et al.
Hasanur Rahman et al.
Introduction: Prostate cancer is one of the most prevalent malignancies and a leading cause of cancer-related deaths among men. The androgen receptor (AR) plays a pivotal role in the development and progression of prostat...
Study on the Mechanism of Action of Qi Zhu Formula in the Treatment of Metabolic-associated Fatty Liver Disease based on Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验验证的气株方治疗代谢相关脂肪性肝病作用机制研究
Junran Yang,Qiuyi Zhang,Zhenhua Zhou
Junran Yang
Introduction: The aim of the study was to investigate the mechanism of Qi Zhu Formula (QZF) against Metabolic-Associated Fatty Liver Disease (MAFLD) via network pharmacology and experimental validation. ...
TOP-BIOCom: A Feature Fusion-based Prediction of Protein Complexes from PPI Networks [0.03%]
基于特征融合的PPI网络蛋白复合物预测方法TOP-BIOCom
Madiha Faqir Hussain,Muhammad Hassan Jamal,Muhammad Waqas Anwar
Madiha Faqir Hussain
Introduction: Protein-Protein Interactions (PPI) are crucial for cellular functions. Computational prediction of protein complexes from PPI networks is essential, yet traditional methods relying solely on network topology...
Mechanism of Coptisine in Rotator Cuff Injury: PI3K/Akt/mTORinflammation Crosstalk Uncovered by Network Pharmacology and Experimental Validation [0.03%]
网络药理学和实验验证发现黄连素治疗肩袖损伤的机制：PI3K/AKT/mTOR炎症互作通路解锁
Jinyao Shang,Zhenyu Yuan,Yufeng Wang et al.
Jinyao Shang et al.
Introduction: This study aimed to investigate the therapeutic mechanism of coptisine in rotator cuff injury (RCI) through network pharmacology and experimental validation. This is the first study to examine the role of co...
Mutations in Penicillin G Acylase: A 4D QSAR-based Approach for Enhancing Efficacy of β-lactam Antibiotics [0.03%]
青霉素G酰基酶的突变：基于4DQSAR的方法增强β-内酰胺抗生素的功效
Roopa Lalitha,Shanthi Veerappapillai
Roopa Lalitha
Introduction: Penicillin G Acylase (PGA) plays a central role in the synthesis of β- lactam antibiotics. While certain variants have been extensively studied, their catalytic efficiency remains suboptimal for industrial ...
Identification of Potential Phytochemical Inhibitors of DNMT1 through Virtual Screening and Molecular Dynamics Simulation to Promote Diabetic Wound Healing [0.03%]
基于虚拟筛选和分子动力学模拟的DNA甲基转移酶1潜在植物化学抑制剂识别促进糖尿病伤口愈合
Kaarthik Saravanan,Reena Rajkumari Baskaran
Kaarthik Saravanan
Introduction: DNA methyltransferase 1 (DNMT1) has recently emerged as a potential therapeutic target for diabetic wound healing (DWH). Studies have shown that inhibition of DNMT1 may be valuable in accelerating DWH. ...
Assessing Lung Injury Induced by Streptozotocin-induced Diabetes: A Deep Neural Network Analysis of Histopathological and Immunohistochemical Images [0.03%]
链脲佐菌素诱导的糖尿病肺损伤的病理评估：基于病理切片和免疫组化图像的深度神经网络分析
Tuğba Şentürk,Demet Bolat,Arzu Yay et al.
Tuğba Şentürk et al.
Introduction: Diabetes mellitus is an endocrine disorder characterized by metabolic abnormalities and chronic hyperglycemia, caused by insulin deficiency (Type I) or resistance (Type II). It affects various tissues differ...
Exploring the Selective Potential Inhibitors for Homologous Protein BD1/BD2 with MD and AIDD Methods [0.03%]
基于MD和AIDD方法探索同源蛋白BD1/BD2的选择性潜在抑制剂
Mengxia Zhao,Junfeng Wan,Yiru Wang et al.
Mengxia Zhao et al.
Introduction: The study aims to explore selective potential inhibitors for the homologous BD1/BD2 domains of bromodomain-containing protein 4 (BRD4) and uncover the binding mechanisms between these inhibitors and BD1/BD2....
Wound Healing Properties of Nymphaea alba (Nymphaeaceae) Flower Extract: Evidence from In Vivo, In Vitro, and In Silico Network Analysis [0.03%]
睡莲（Nymphaea alba）花朵提取物的伤口愈合特性：基于体内，体外和网络分析的证据
Deepika Pathak,Avijit Mazumder
Deepika Pathak
Introduction: The white water lily (Nymphaea alba) is a traditional medicinal plant recognized for its diverse array of bioactive properties. However, its potential in wound healing remains largely unexplored. This study ...
Through Network Pharmacology Combined with Artificial Intelligence Techniques, Potential Targets of Banxia Xiexin Decoction for the Treatment of Functional Dyspepsia were Identified and Validated [0.03%]
基于网络药理学结合人工智能技术的半夏泻心汤治疗功能型消化不良潜在靶点筛选及验证
Lang Ren,Yiyao Cheng,Hanlin Dong et al.
Lang Ren et al.
Background: Banxia Xiexin Decoction (BXD) has been shown to exert therapeutic effects on Functional dyspepsia (FD). This study aims to investigate the therapeutic mechanisms of BXD in treating FD. ...