Assessing Lung Injury Induced by Streptozotocin-induced Diabetes: A Deep Neural Network Analysis of Histopathological and Immunohistochemical Images [0.03%]
链脲佐菌素诱导的糖尿病肺损伤的病理评估：基于病理切片和免疫组化图像的深度神经网络分析
Tuğba Şentürk,Demet Bolat,Arzu Yay et al.
Tuğba Şentürk et al.
Introduction: Diabetes mellitus is an endocrine disorder characterized by metabolic abnormalities and chronic hyperglycemia, caused by insulin deficiency (Type I) or resistance (Type II). It affects various tissues differ...
Exploring the Selective Potential Inhibitors for Homologous Protein BD1/BD2 with MD and AIDD Methods [0.03%]
基于MD和AIDD方法探索同源蛋白BD1/BD2的选择性潜在抑制剂
Mengxia Zhao,Junfeng Wan,Yiru Wang et al.
Mengxia Zhao et al.
Introduction: The study aims to explore selective potential inhibitors for the homologous BD1/BD2 domains of bromodomain-containing protein 4 (BRD4) and uncover the binding mechanisms between these inhibitors and BD1/BD2....
Wound Healing Properties of Nymphaea alba (Nymphaeaceae) Flower Extract: Evidence from In Vivo, In Vitro, and In Silico Network Analysis [0.03%]
睡莲（Nymphaea alba）花朵提取物的伤口愈合特性：基于体内，体外和网络分析的证据
Deepika Pathak,Avijit Mazumder
Deepika Pathak
Introduction: The white water lily (Nymphaea alba) is a traditional medicinal plant recognized for its diverse array of bioactive properties. However, its potential in wound healing remains largely unexplored. This study ...
Through Network Pharmacology Combined with Artificial Intelligence Techniques, Potential Targets of Banxia Xiexin Decoction for the Treatment of Functional Dyspepsia were Identified and Validated [0.03%]
基于网络药理学结合人工智能技术的半夏泻心汤治疗功能型消化不良潜在靶点筛选及验证
Lang Ren,Yiyao Cheng,Hanlin Dong et al.
Lang Ren et al.
Background: Banxia Xiexin Decoction (BXD) has been shown to exert therapeutic effects on Functional dyspepsia (FD). This study aims to investigate the therapeutic mechanisms of BXD in treating FD. ...
Elucidating the Mechanisms of a Patented Chinese Herbal Medicine for Ovarian Cystadenoma via Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations [0.03%]
基于网络药理学、分子对接及分子动力学模拟的专利中药少腹逐瘀方治疗卵巢囊腺瘤机制探讨
Qianping Wang,Yonghui Yu
Qianping Wang
Introduction: Ovarian cystadenoma (OC) is a common benign tumor in women. Wang's formula for gynecological masses (WGM), a patented traditional Chinese medicine, was reported to have therapeutic potential for OC. ...
Decoding the Molecular Mechanism of Bioactive Compounds Derived from Microalgae via Transcriptomics Data and Integrative Bioinformatics Analysis [0.03%]
基于转录组数据和集成生物信息学分析的微藻来源生物活性化合物作用机制研究
Hina Shahid,Muhammad Ibrahim,Wadi B Alonazi et al.
Hina Shahid et al.
Introduction: Microalgae, with their high photosynthetic efficiency and sustainability, hold promise to produce bioactive compounds, chemicals, cosmetics, and biofuels. This study aims to understand the molecular mechanis...
Elucidating the Mechanism of Xiaoqinglong Decoction in Chronic Urticaria Treatment: An Integrated Approach of Network Pharmacology, Bioinformatics Analysis, Molecular Docking, and Molecular Dynamics Simulations [0.03%]
小青龙汤治疗慢性荨麻疹的机制研究：网络药理学、生物信息学分析、分子对接及分子动力学模拟综合研究方法探讨
Zhengjin Zhu,Lu Liu,Meihong Li et al.
Zhengjin Zhu et al.
Introduction: Xiaoqinglong Decoction (XQLD) is a traditional Chinese medicinal formula commonly used to treat chronic urticaria (CU). However, its underlying therapeutic mechanisms remain incompletely characterized. This ...
A Comprehensive Molecular Dynamic Simulation Study of Plant Bioactive Phytoconstituents as Inhibitors for SARS-CoV-2 Main Protease and Spike (S) Glycoprotein [0.03%]
植物生物活性成分作为冠状病毒主蛋白酶和刺突蛋白抑制剂的综合分子动力学模拟研究
Vinay Mohan Kandpal,Apoorv Tiwari,Pranabesh Mandal et al.
Vinay Mohan Kandpal et al.
Background: Since the commencement of the COVID-19 pandemic, researchers have been earnestly exploring the capacity of diverse bioactive compounds present in plants to impede the transmission of SARS-CoV-2. Plants have al...
Investigation of Novel Etoricoxib Analogues as Potential COX-II Inhibitors through a Bioisosteric Strategy, ADMET Evaluations, Docking Studies, and Molecular Dynamics Simulations [0.03%]
基于生物电子等排体策略、ADMET评价、对接研究及分子动力学模拟的新型埃托考昔类似物作为COX-II抑制剂的研究
Girija Prasad Swain,Sanmati Kumar Jain,Ajay Kumar Gupta et al.
Girija Prasad Swain et al.
Background: Inflammation is a natural process; however, chronic inflammation may result in numerous health issues. Etoricoxib (ETX), a selective cyclooxygenase-2 (COX-2) inhibitor, serves as an anti-inflammatory agent for...
A Multiscale Computational Study for the Identification of Novel Inhibitors Targeting Tau-Tubulin Kinase 1 (TTBK1) in Alzheimer's Disease [0.03%]
一种针对Tau-肌动蛋白激酶1(TTBK1)的新型抑制剂鉴定的多层次计算研究以用于阿尔茨海默病治疗
Prashant Kurkute,Sumit Sonawane,Kumar Pratyush et al.
Prashant Kurkute et al.
Introduction: Excessive phosphorylation of tau protein by the tau-tubulin kinase 1 (TTBK1) enzyme is implicated in the pathogenesis of several neurodegenerative diseases. Based on a comprehensive literature review and ava...