Mechanistic Study of Traditional Chinese Medicine Compound Containing Ginseng Radix et Rhizoma in the Treatment of Colorectal Cancer [0.03%]
人参复方中药治疗结直肠癌的机制研究
Wei Yue,Liwen Zhang,Jiazhi Xu et al.
Wei Yue et al.
Introduction: Colorectal Cancer (CRC) is a prevalent gastrointestinal malignancy with complex pathogenesis involving genetic and epigenetic alterations and multi‑pathway dysregulation. Traditional Chinese Medicine (TCM) ...
DecoyFinderNetAna: Application of Graph Convolution Neural Networks for Accurate Classification of True Small Molecule Binders from their Decoys [0.03%]
用于从诱饵分子中准确分类真正的小分子结合物的图卷积神经网络的应用：DecoyFinderNetAna
Akshat Jha,Shreyansh Suyash,Manjusha Govindh et al.
Akshat Jha et al.
Introduction: The drug discovery pipeline faces significant challenges, often requiring extensive screening to differentiate between true ligands and decoys. Computational biology techniques, particularly those involving ...
Jinwei Guben Formula (Jinwei Formula II) Modulates Neutrophil Extracellular Trap Formation and Enhances Glucocorticoid Efficacy in COPD Through HDAC2 Regulation [0.03%]
金水健肺方调控中性粒细胞胞外陷阱形成及增强慢性阻塞性肺疾病糖皮质激素疗效的作用机制（II）：通过HDAC2表观遗传调控实现
Jianjun Wu,Wenjuan Zhang,Deyu Kong et al.
Jianjun Wu et al.
Introduction: Neutrophil extracellular traps (NETs) contribute to chronic inflammation in chronic obstructive pulmonary disease (COPD). Jinwei Guben Formula (JWGB) is a clinically used TCM for COPD, but its mechanism rega...
Study on the Mechanism of Ku Diding in the Treatment of Diabetes based on Network Pharmacology, Molecular Docking Technology, and Molecular Dynamics [0.03%]
基于网络药理学、分子对接技术及分子动力学的库尔勒迪 Ding 治疗糖尿病机制研究
Qingyun Chi,Tao Zheng,Bin Yang
Qingyun Chi
Introduction: To explore how Ku Diding (KDD) works in managing Diabetes Mellitus (DM), researchers utilized network pharmacology, molecular docking, and molecular dynamics methodologies. ...
Potential Inhibitors of Mycobacterium abscessus VapC5 Protein: A Molecular Dynamics Simulation Study [0.03%]
基于分子动力学模拟的胞外致病菌鸟分枝杆菌败血症型VapC5蛋白抑制剂研究
Maira Bibi,Shaoyuan Zeng,Muhammad Tahir Khan et al.
Maira Bibi et al.
Introduction: Mycobacterium abscessus (MAB) is severely resistant to available antibacterial agents. The current study aimed to find natural inhibitors against MAB to fight the resistant isolates. ...
Machine Learning-driven ADHD Classification: Exploring Medication Effects with VMD Sub-band Analysis [0.03%]
基于机器学习的注意缺陷多动障碍分类：具有VMD子带分析的药物效应探索
Ebru Aker,Şerife Gengeç Benli,Zeynep Ak
Ebru Aker
Introduction: There has been increasing interest in neuroimaging studies in recent years, and computer-aided approaches have gained prominence in improving diagnostic accuracy. Attention Deficit Hyperactivity Disorder (AD...
Integrated Network Pharmacology, LC-MS/MS, and Experimental Validation of Fangji-astragalus in Hyperlipidemia [0.03%]
基于网络药理学、液质联用及实验验证的防己黄芪汤治疗高脂血症的作用机制研究
Wangqin Wu,Mi Zhang,Chunlei Fan
Wangqin Wu
Introduction: Hyperlipidemia is linked to multiple cardiovascular and cerebrovascular diseases. Traditional Chinese Medicine formulations show potential for managing this condition, but the underlying mechanisms remain un...
Exploring the Mechanism of Qigesan in Treating Esophageal Carcinoma Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation [0.03%]
基于网络药理学、分子对接及分子动力学模拟的枳壳散治疗食管癌机制探讨
Shun Zhang,Haolan You,Shixin Ye et al.
Shun Zhang et al.
Background: Qigesan (QGS) is a traditional Chinese herbal medicine used for the treatment of esophageal carcinoma (EC) and possesses anti-cancer properties. However, the mechanism of QGS in the treatment of EC remains unc...
A Comprehensive Strategy for Component Screening and Mechanism Determination of Paris Polyphylla Var. Yunnanensis in Anti-liver Cancer [0.03%]
云南白药止癌成分筛选及机制确定的综合策略
Hanzhu Sun,Le Wang,Jin Sun et al.
Hanzhu Sun et al.
Introduction: Paris Polyphylla var. Yunnanensis (PY) is an anti-liver cancer TCM used in clinical practice, but its core components and anti-liver cancer mechanism remain unclear. This study combines animal experiments, n...
Study Integrating GWAS and pQTL Data Identifies Potential Therapeutic Targets for Hypertension [0.03%]
整合GWAS和pQTL数据识别高血压潜在治疗靶点的研究
Yiduo Wang,Huan Qu
Yiduo Wang
Background: Hypertension, a major risk factor for cardiovascular disease morbidity and mortality, remains poorly controlled in many patients despite available treatments. There are many patients with poorly managed blood ...