Exploring Structural Requirement of Curcumin-Based CK2 Inhibitors as Anticancer Agents: 3D-QSAR, Pharmacophore Modeling, Virtual Screening, and Molecular Docking [0.03%]
基于姜黄素的CK2抑制剂作为抗癌制剂的结构要求的探究：3D QSAR、药效团建模、虚拟筛选及分子对接研究
Firdous Fatima,Priyanshu Nema,Anushka Garhwal et al.
Firdous Fatima et al.
Introduction: Casein Kinase 2 (CK2), discovered as one of the earliest protein kinases, is a ubiquitous Ser/Thr protein kinase-specific to acidic environments. CK2 has been implicated in regulating diverse cellular proces...
Docking and Molecular Dynamics Studies on Anticancer Activities of Flavonoids as Inhibitors of CDK2 and CDK9 [0.03%]
flavonoids抗肿瘤活性的分子对接及分子动力学研究*(CDK2和CDK9抑制剂)
A S Sony,M Xavier Suresh
A S Sony
Background: Flavonoids express a wide range of medicinal properties, our study presented results on the anticancer activity of selected compounds using in silico studies. ...
Exploring Thiophene Derivatives: Synthesis Strategies and Biological Significance [0.03%]
噻吩衍生物的探索：合成策略与生物学意义
Isha Mishra,Vikram Sharma,Nitin Kumar et al.
Isha Mishra et al.
Objectives: Thiophene is one of the most important heterocyclic scaffolds with notable pharmacological properties. Thiophene and its derivatives are of particular interest among sulphurcontaining heterocycles because of t...
Platinum Group Metals against Parasites: State of the Art and Future Perspectives [0.03%]
铂族金属抗寄生虫研究：现状与未来展望
Jose Manuel Mendez-Arriaga
Jose Manuel Mendez-Arriaga
Background: Globally, parasitic diseases are considered among the neglected diseases. Clinically, several drugs are used in treatment, however due to drug resistance and multidrug resistance and the low investment in new ...
Exploring Pyridine-Based Schemes: A Comprehensive Review on their Synthesis and Therapeutic Applications [0.03%]
基于吡啶的方案的研究：关于其合成和治疗应用的全面回顾
Amruta M Balikai,M R Pradeep Kumar,Kalirajan Rajagopal et al.
Amruta M Balikai et al.
Pyridine and its derivatives are six-membered aromatic rings containing nitrogen, which are abundant in nature and indispensable in studying heterocyclic chemistry. They constitute significant chemical substances with numerous applications....
Integrating Machine Learning and Pharmacophore Features for Enhanced Prediction of H1 Receptor Blockers [0.03%]
结合机器学习和药效团特征以增强H1受体阻断剂的预测能力
Zaid Anis Sherwani,Mohammad Nur-E-Alam,Aftab Ahmed et al.
Zaid Anis Sherwani et al.
Introduction: Histamine Type I Receptor Antagonists (H1 blockers) are widely used to mitigate histamine-induced inflammation, particularly in allergic reactions. Histamine, a biogenic amine found in endothelial cells, vas...
Pyridine Derivatives: A Comprehensive Review of Their Potential as Anti-Diabetic Agents [0.03%]
吡啶衍生物：其作为抗糖尿病剂的潜力综述
Deepak Dua,Prakash Kumar,Riya Anand et al.
Deepak Dua et al.
Background: Diabetes mellitus and obesity are two of the most frequent health conditions in the world, prompting medical researchers to seek novel effective treatments. According to World Health Organization (WHO) regulat...
Exploring 1-Azaaurones: A Concise Overview of Synthetic Strategies and Biological Activities [0.03%]
1-氮杂奥龙的研究：合成策略和生物活性综述
Naveen Chauhan,Suresh Kumar
Naveen Chauhan
Azaaurones are formed by the replacement of intra-cyclic oxygen of the central core of a five-membered furan ring or any other carbon of aurones by a nitrogen atom. However, 1- azaaurone obtained by the replacement of intra-cyclic oxygen is...
Zhou Dejun,Zhang Yuying,Liu Xiaoyue et al.
Zhou Dejun et al.
Background: Dopamine (1) is a commonly used vasopressor, primarily employed to treat various types of shock, congestive heart failure, and acute renal failure. Dopamine dimer (2) is an impurity generated during the produc...
Synthetic Strategies for the Development of Novel Heterocycles as Larvicides Targeting Aedes aegypti Linn [0.03%]
针对埃及伊蚊的新颖杂环杀幼虫剂的合成策略
Thaysnara Batista Brito,Luana Marília Santos Oliveira,Rafaela Karolina Viana Nunes et al.
Thaysnara Batista Brito et al.
Background: Owing to their extensive utilization as pesticides, heterocycles assume a fundamental role in the management of vector-borne diseases. Despite the presence of numerous heterocyclic compounds in commercial inse...