Design, Synthesis, and Biological Evaluation of Novel 7-Hydroxycoumarin- Based N-Hydroxyamides as Histone Deacetylase Inhibitors and Cytotoxic Agents [0.03%]
一类新的组蛋白去乙酰化酶抑制剂和细胞毒活性的7-羟基香豆素基N-羟胺类化合物的设计、合成及生物活性评价
Tran Duy Thanh,Vu Xuan Thach,Luu Van Chinh et al.
Tran Duy Thanh et al.
Introduction: Histone deacetylases (HDACs) play a crucial role in gene expression, and their dysregulation is linked to various cancers. HDAC inhibitors, particularly hydroxamic acid derivatives, have shown promising anti...
Virtual Screening of FDA-Approved Drugs on Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) to Obtain New Trypanocidal Agents [0.03%]
基于甘油醛-3-磷酸脱氢酶（GAPDH）虚拟筛选FDA批准药物以获得新的查帕酮类化合物
Alfredo Juarez-Saldivar,Lenci K Vazquez-Jimenez,Eyra Ortíz-Pérez et al.
Alfredo Juarez-Saldivar et al.
Introduction: The protozoan parasite Trypanosoma cruzi (T. cruzi) is the etiologic agent of Chagas disease, also known as American trypanosomiasis, which primarily affects the Americas and is highly prevalent in developin...
Priyanshi Choudhary,Manisha Bhatti
Priyanshi Choudhary
Quinolones are nitrogen-containing heterocyclic compounds that exist in natural, semisynthetic, and synthetic forms, and play a vital role as antibiotics. Their complex structure and numerous potential modifications have made them a signifi...
Shilpi Pathak,Kenika Sharma,Anmol Goswami et al.
Shilpi Pathak et al.
Oxindole and its derivatives have emerged as interesting scaffolds for developing innovative anticancer medicines due to their various biological activities and capacity to target critical molecular pathways in cancer growth. The oxindole n...
Unveiling the Therapeutic Potential of 8-Hydroxyquinoline: A Multi-Targeting Approach [0.03%]
8-羟基喹啉治疗潜力的揭示：多靶点策略
Riddhisiddhi Patel,Drashti Shah,Ashish Patel
Riddhisiddhi Patel
In recent years, extensive research has been conducted by medicinal and organic chemists on derivatives of 8-Hydroxyquinoline (8-HQ) due to their potential as therapeutic agents for a wide range of diseases and disorders. These derivatives ...
Hypolipidemic and Hepatoprotective Effects of 5-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)Pentanoic Acid (TDPPA) on Hyperlipidemic Mice [0.03%]
5-(4-(3-硫代-3h-1,2-二噻-5-基)苯氧基)戊酸(TDPPA)对高脂血症小鼠的降血脂和保肝作用
Ting Li,Manjun Liu,Qiuzhen Yuan et al.
Ting Li et al.
Introduction: Hyperlipidemia is a prevalent condition that accelerates the development of cardiovascular diseases. Traditional treatments targeting lipid regulation often have limitations, such as hepatotoxicity. This stu...
Virtual Screening of HBV Capsid Assembly Modulators with the Combination of Pharmacophore Modeling and Hydrogen Bond Constraints [0.03%]
基于药效团模型和氢键约束的HBV衣壳组装调节剂虚拟筛选研究
Hui Zhao,Yunwen Wang,Huihui Yan et al.
Hui Zhao et al.
Introduction: Hepatitis B virus (HBV) infection remains a significant public health challenge. Targeting HBV capsid assembly has the potential to achieve a functional cure for HBV infection, and the capsid assembly modula...
Stereoisomerism in Chemistry and Drug Development: Optical, Geometrical, and Conformational Isomers [0.03%]
化学和药物开发中的立体异构现象：光学异构体、几何异构体和构象异构体
Shivani Chawla,Rishikesh Gupta,Sudhanshu Kumar Jha et al.
Shivani Chawla et al.
Stereoisomerism in addition to conformational, geometrical, and optical isomerism, has considerable effects on the stability, reactivity, and functioning of molecules. Therefore, the objective of this article is to review the recent develop...
Dimitra Hadjipavlou-Litina
Dimitra Hadjipavlou-Litina
A Step Towards Development and Bio-evaluation of a Novel Radio-ligand 99mTc-CYX-DTPA Targeting Sigma 2 Receptors [0.03%]
新型放射配体99mtc-cyx-dtpa的作用机制及Sigma-2受体显像的初步研究
Ritika Chaudhary,Shubhra Chaturvedi,Divya Gautam et al.
Ritika Chaudhary et al.
Introduction: Development of theranostics agents targeted towards particular receptors can effectively help in the management of cancer. The overexpression of the sigma-2 receptor (S2R) in tumors establishes it as a promi...