Design and Synthesis of 3-(Phenylsulfonamido)benzamide Derivatives as Potent Carbonic Anhydrase IX Inhibitors: Biological Evaluations and Molecular Modeling Studies [0.03%]
3-（苯磺酰胺基）苯甲酰衍生物的设计与合成作为强有力的碳酸酐酶IX抑制剂：生物学评估和分子建模研究
Mohammad A Khanfar,Mohammad Saleh
Mohammad A Khanfar
Introduction: Carbonic anhydrase IX (CAIX) is known to be overexpressed in various tumors and plays a significant role in tumor development and progression. ...
In Silico Studies of Phytoconstituents to Identify Potential Inhibitors for ERα Protein of Breast Cancer [0.03%]
天然植物活性成分对乳腺癌ERα蛋白的抑制作用的计算机研究
Veerachamy Alagarsamy,Mohaideen Thasthagir Sulthana,Bandi Narendhar et al.
Veerachamy Alagarsamy et al.
Background: It is noteworthy that a wide array of plants and nutraceuticals are effectively utilized in the treatment of various cancers, demonstrating potent effects on different cancer targets with fewer side effects. N...
Exploring Quinoline Derivatives: Their Antimalarial Efficacy and Structural Features [0.03%]
喹啉衍生物的探索：它们的抗疟效力和结构特征
Raghav Mishra,Jayze da Cunha Xavier,Nitin Kumar et al.
Raghav Mishra et al.
Objectives: Malaria continues to be the primary cause of mortality worldwide, and timely recognition and prompt intervention are crucial in mitigating adverse consequences. This review article aims to examine the effectiv...
Exploring the Diverse Therapeutic Applications of 1, 3-Thiazine: A Comprehensive Review [0.03%]
1,3-噻嗪的多种治疗应用综述
Neetu Agrawal,Deepika Goyal,Shilpi Pathak
Neetu Agrawal
Thiazine, a six-membered heterocycle containing nitrogen and sulfur atoms, is of paramount importance due to its diverse biological functions and broad therapeutic effects. The pharmacological attributes of 1,3-thiazine span a wide range of...
Design, Synthesis, Characterization, and Antitumor Activities of Benzimidazole-functionalized Organoruthenium Complexes Bearing Fluorine Group [0.03%]
含氟苯并咪唑功能化的有机钌配合物的设计、合成、表征及其抗肿瘤活性研究
Ramazan Paşahan,Özlem Demirci,Irmak İçen Taşkın et al.
Ramazan Paşahan et al.
Background: This work presents the synthesis of Ru(II)NHC complexes bearing a series of 4-fluorobenzyl group. These complexes have been characterized by a variety of spectroscopic methods (1H NMR, 13C NMR, and FTIR) and b...
Synergistic Warriors: Design and Synthesis of Dual-Acting Schiff-Based Threaded 1,2,3-Triazole Hybrids for Potent Antineoplastic and Anti-Mycobacterial Activities [0.03%]
协同战士：设计合成具有抗肿瘤和抗分枝杆菌活性的双重作用希夫碱基穿线1,2,3-三唑杂化物
Vinayak Walhekar,Raghavendra Kulkarni,Mohana Vamsi Nuli et al.
Vinayak Walhekar et al.
Objective: In the pursuit of identifying divergent scaffolds for potential anticancer and anti-mycobacterial agents, a novel series of Schiff-based threaded 1,2,3-triazoles was designed and synthesized. ...
Discovery of the PARP1 Inhibitors from Natural Compounds Using Structure-Based Virtual Screening and Bioactivity Evaluation [0.03%]
基于结构虚拟筛选和生物活性评价从天然化合物中寻找PARP1抑制剂
Dabo Pan,Yaxuan Huang,Dewen Jiang et al.
Dabo Pan et al.
Background: PARP1 (poly ADP-ribose polymerase 1, also known as ADPRT1) plays a significant role in DNA repair and has become an attractive target for treating PARP1-related diseases, such as cancer. ...
In silico Identification and Computational Screening of Potential AFP Inhibitors Against Liver Cancer [0.03%]
基于计算机的AFP抑制剂筛选及潜在肝癌治疗靶点识别研究
Hassan Bin Waseem,Muhammad Shakeel,Faiz-Ul Hassan et al.
Hassan Bin Waseem et al.
Introduction: Liver cancer is considered one of the most common types of cancer and a major cause of ephemerality worldwide having a higher prevalence rate in Asia and sub-Saharan Africa. The alpha-fetoprotein (AFP) is a ...
Unlocking the Biological Potential of 2-Pyridones: Synthesis, Antioxidant and Antimicrobial Activity of N-Phenacylated 5/6-Chloro-2-pyridones [0.03%]
2-吡啶酮生物潜力的开发：N-苯酰化5/6-氯-2-吡啶酮的合成，抗氧化和抗菌活性
Sarita Sangwan,Sonu Chauhan,Neelam Yadav et al.
Sarita Sangwan et al.
Aim: A simple and efficient synthesis of 14 new (9a-9n) N-phenacyl-2-pyridones with good yields (up to 75%), is reported. The synthesized derivatives were screened for their in vitro radical scavenging activity against 1,...
Bioactive Compounds from Myrica esculenta: Antioxidant Insights and Docking Studies on H+K+-ATPase and H2 Receptor Targets [0.03%]
Myrica esculenta生物活性化合物：抗氧化研究及H+K+-ATP酶和H2受体靶标的分子对接研究
Rashmi Pathak,Phool Chandra
Rashmi Pathak
Background: Myrica esculenta (Myricaceae) are common in the Indian Himalayas. Traditional medicine uses it to treat chronic bronchitis, inflammation, stomach ulcers, anaemia, diarrhoea, asthma, and ear, throat, and nose d...