Reducing Cabozantinib Toxicity in Renal Cell Carcinoma Treatment through Structural Modifications [0.03%]
通过结构改良降低卡博替尼治疗肾细胞癌的毒性
Jiaxiang Guo,Xiaotao Yin,Yongliang Lu et al.
Jiaxiang Guo et al.
Background and objectives: Cabozantinib, a Tyrosine Kinase Inhibitor (TKI), is widely used in Renal Cell Carcinoma (RCC) therapy but often causes serious side effects such as myelosuppression, immunosuppression, and angio...
Expanding Therapeutic Horizons with Indazole-Based Compounds: A Review of Anticancer, Antimicrobial, and Neuroprotective Applications [0.03%]
基于吲唑化合物的治疗前景拓展：抗肿瘤、抗菌和神经保护作用综述
Pooja Dinkar Bhane,Sarita Suryabhan Pawar
Pooja Dinkar Bhane
Indazole-based compounds have recently developed and physiologically evaluated as diverse agents for antibacterial, anticancer, anti-inflammatory, anti-obesity, and neurological therapies. This review highlights these advancements. Through ...
Pyrazole and Pyrazoline-Based EGFR TK Inhibitors: A Review Study Emphasizing Structure-Activity Relationship (SAR) [0.03%]
基于吡唑和吡唑啉的EGFR TK抑制剂：着重结构活性关系（SAR）的综述研究
Shruti Mittal,Ozair Alam,Lakshay Singh et al.
Shruti Mittal et al.
Unusual cell growth patterns, metastasis (the spread of tumors to other parts of the body), and potential death are all hallmarks of cancerResearch in oncology clearly shows that abnormalities in EGFR expression directly contribute to uncon...
Integrated Artificial Intelligence and Physics-Based Methods for the De Novo Design of Spleen Tyrosine Kinase (SYK) Inhibitors [0.03%]
结合人工智能和基于物理的方法从头设计脾酪氨酸激酶(SYK)抑制剂
Atul Darasing Pawar,Heba Taha M Abdelghani,Hemchandra Deka et al.
Atul Darasing Pawar et al.
Introduction: SYK (Spleen Tyrosine Kinase) regulates immune response and is a promising target for cancer, sepsis, and allergy therapies. This study aims to create novel compounds that serve as alternative inhibitors for ...
Pyrimidine-Based Compounds in Tuberculosis Management: A Review of their Biological and Medicinal Importance [0.03%]
嘧啶类化合物在结核病管理中的生物学和药理学重要性综述
Deepshikha Singh,Vikram Singh,Afrasim Moin et al.
Deepshikha Singh et al.
Pyrimidine derivatives are a class of chemically & biologically active heterocyclic compounds promising for developing anti-tubercular, anti-viral, anti-malarial, anti-inflammatory, and enzyme-inhibiting drugs. To cure TB, scientists were d...
Characterization of the Cytotoxic Effect of Naphthalenacetamides Hydrochlorides on Cervical Cancer-Derived Cells [0.03%]
萘酰胺盐对宫颈癌细胞毒性的特征分析
Cristina Martinez-Nava,Cuauhtemoc Perez-Gonzalez,Miguel Ángel Zavala-Sanchez et al.
Cristina Martinez-Nava et al.
Introduction: Cervical cancer is a global health problem due to its high incidence and prevalence in women, mainly in third-world countries. For the treatment of this disease, there are different therapeutic options, but ...
Application of Iodine-Amine Oxidation Approach in the Synthesis of Various N-Alkyl Phosphoramidate Oligonucleotide Derivatives [0.03%]
碘-胺氧化法在各种N-烷基磷酰胺核酸衍生物合成中的应用
Mikhail D Nekrasov,Dmitrii V Pyshnyi,Maxim S Kupryushkin
Mikhail D Nekrasov
Introduction: Nowadays, use of phosphate modifications in oligonucleotide backbone has become a common approach for imbuing its structure with the desired beneficial properties. The recent advances in successful applicati...
Exploring Phytochemicals as Potential Inhibitors of Cancer Cell Metabolic Pathways: A Computational Study [0.03%]
探索植物化学物质作为潜在的癌症细胞代谢途径抑制剂的计算研究
Yagyesh Kapoor,Yasha Hasija
Yagyesh Kapoor
Objective: The objective of this study is to explore the therapeutic potential of phytochemicals in cancer cell metabolism by investigating their ability to inhibit key molecular targets involved in tumor growth and drug ...
Emerging Role of Natural Topoisomerase Inhibitors as Anticancer agents [0.03%]
天然拓扑异构酶抑制剂作为抗癌药物的新兴作用
Sanjeev Kumar Sahu,Manish Vyas,Pranav Kumar Prabhakar
Sanjeev Kumar Sahu
Topoisomerases I and II are the functionally two forms of DNA topoisomerase. In anticancer research, novel anticancer chemotherapeutical capable of blocking topoisomerase enzymes have been discovered. Most commonly, topoisomerase causes rep...
Benzimidazole Conjugates as Multi-target Anticancer Agents - A Comprehensive Review [0.03%]
苯并咪唑偶联物作为多靶点抗癌剂的综合评价
R S Remya,N Ramalakshmi,M G Safiya Aaliya et al.
R S Remya et al.
Cancer is the second leading cause of mortality globally and is characterized by a multifactorial etiology. Drug resistance and multidrug resistance are the reasons for the failure of many anticancer drugs that are in clinical practice now....