Exploring Cannabis sativa L for Anti-Alzheimer Potential: An Extensive Computational Study including Molecular Docking, Molecular Dynamics, and ADMET Assessments [0.03%]
大麻植物抗阿尔茨海默潜力的计算研究包括分子对接、分子动力学及ADMET评估
Hassan Nour,Imane Yamari,Oussama Abchir et al.
Hassan Nour et al.
Introduction: Cholinesterase enzymes play a pivotal role in hydrolyzing acetylcholine, a neurotransmitter crucial for memory and cognition, into its components, acetic acid, and choline. A primary approach in addressing A...
Yasuhiro Ozeki,S M Abe Kawsar
Yasuhiro Ozeki
Optimized Strategies for the Synthesis and Structure-Activity Relationship of Imidazole as an Antiepileptic Drug [0.03%]
咪唑类抗癫痫药物的合成及构效关系研究进展
Saloni Mangal,Salahuddin,Avijit Mazumder et al.
Saloni Mangal et al.
Imidazole is believed to be a highly multifunctional compound in the medicinal and biological sectors. This literature focuses on information about the synthesis and anticonvulsant activity presented by the imidazole nucleus. Epilepsy is a ...
Novel Pyrrolopyrimidines as Inhibitors of CLK4 and HER2: Targeting Promising Anticancer Pathways [0.03%]
新型噁二唑并嘧啶类化合物作为CLK4和HER2抑制剂：针对有前景的抗癌通路
Jonathan Gries,Frank Totzke,Andreas Hilgeroth
Jonathan Gries
Background: Dysregulated cellular signaling pathways involving protein kinases are critically implicated in cancer development. Consequently, protein kinases have emerged as key targets for novel anticancer therapies. A r...
Potential Inhibitors of SARS-CoV-2 Developed through Machine Learning, Molecular Docking, and MD Simulation [0.03%]
基于机器学习、分子对接和MD模拟的SARS-CoV-2潜在抑制剂开发
Arshiya Khan,Anushka Bhrdwaj,Khushboo Sharma et al.
Arshiya Khan et al.
Background: The advent of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) pandemic, has impacted physical and mental health worldwide. The lac...
Research Progress of G Protein-coupled Receptor 52 on Central Nervous System Diseases [0.03%]
G蛋白偶联受体52在中枢神经系统疾病研究进展
Qingkun Wu,Jun Li,Xiaojie Hu et al.
Qingkun Wu et al.
The G protein-coupled receptor 52 (GPR52) is a Gs-coupled receptor and is located principally in the striatum alongside D2 receptor and in the pre-frontal cortex alongside D1 receptor. Its stimulation leads to potentiation of intracellular ...
Işıl Yıldırım
Işıl Yıldırım
Natural Mimetic 4,6-dihydroxyaurone Derivatives as Tyrosinase Inhibitors: Design, Synthesis, and Biological Evaluation [0.03%]
天然拟效的4,6-羟基黄酮衍生物作为酪氨酸酶抑制剂：设计，合成及生物活性评价
Quoc-Thai Nguyen,Giao Quynh Tran,Huy Thanh Ta et al.
Quoc-Thai Nguyen et al.
Introduction: Tyrosinase, a key enzyme in melanin biosynthesis and food browning, has become an important target for inhibitor development. Aim: ...
Discovering the Cholinesterase Inhibitory Potential of Thiosemicarbazone Derivatives through In vitro, Molecular Docking, Kinetics, and Dynamics Studies [0.03%]
基于体外、分子对接、动力学和分子动力学研究发现噻二唑并线硫代半卡 checkboxes羧胺衍生物的乙酰胆碱酯酶抑制潜能
Manel Essid,Aftab Alam,Ghulam Fareed et al.
Manel Essid et al.
Background: The current study explored the cholinesterase inhibitory activities of some thiosemicarbazone derivatives bearing 2,4-dichloro phenylacetic acid scaffold. ...
Synthesis, Characterization, and Pharmacological Evaluation of Zn4O(BDC)3: Anticancer, Antidiabetic, and Drug Delivery Potential [0.03%]
Zn4O(BDC)3的合成、表征及其药理评价：抗肿瘤、抗糖尿病及药物输送潜力
Sabir Khan,Muhammad Fazal Hameed,Imran Zafar et al.
Sabir Khan et al.
Introduction: This study presents a comprehensive exploration of the biomedical potential of the synthesized metal-organic framework Zn4O(BDC)3, focusing on its applications in cancer and diabetes treatment and its advanc...