Chitosan-Based Materials: A Comprehensive Review on Anticancer Drug Development [0.03%]
基于壳聚糖的材料：抗癌药物开发综述
Faris J Tayeb,Mohammed Fareed Felemban,Amal Adnan Ashour et al.
Faris J Tayeb et al.
Cancer remains one of the most formidable global health threats, responsible for millions of deaths annually due to the uncontrolled proliferation and spread of abnormal cells. The development of effective anticancer therapies is crucial, a...
Recent Advances in Molecular Docking Techniques: Transforming Perspectives in Distinct Drug Targeting and Drug Discovery Approaches [0.03%]
分子对接技术的新进展：重塑药物靶点和新药研发的视角
Rashid M Ansari,Radhika N Mundke,Yogeeta O Agrawal et al.
Rashid M Ansari et al.
Introduction: Drug targeting and drug discovery methodologies are advancing rapidly due to recent developments in molecular docking techniques. Molecular docking forecasts the interactions between a small molecule, such a...
Işıl Yıldırım
Işıl Yıldırım
A Search for New Amidrazone Derivatives Containing 4-Oxybut-2-enoic Acid Moiety as Antibacterial Agents [0.03%]
一类含4-氧代丁烯酸结构片段的氨idrazones衍生物的抗菌活性研究
Renata Paprocka,Monika Przybysz,Kamila Pośpieszyńska et al.
Renata Paprocka et al.
Introduction: Bacterial diseases pose a significant challenge to modern medicine due to the rapid development of resistance by bacterial strains and the global migration of people, which facilitates the transmission of th...
Identification of Potential Dual HDAC6 and HSP90 Inhibitors for the Treatment of Cancer using Molecular Docking, Molecular Dynamics and MM/PBSA Studies: A Comprehensive In Silico Study [0.03%]
基于分子对接、分子动力学和MM/PBSA研究的潜在癌症治疗型组蛋白脱乙酰酶6和HSP90双靶向抑制剂的鉴定：一项全面的计算机模拟研究
Muhsin Samet Yücel,İsmail Akçok
Muhsin Samet Yücel
Background: Histone deacetylase 6 (HDAC6) and heat shock protein 90 (Hsp90) are crucial therapeutic targets in cancer research with their interconnected roles in regulating protein homeostasis and cellular processes. The ...
Antioxidant and Cytotoxic Activity of the Aporphine Alkaloid (Boldine) Against DMH-induced Colorectal Carcinogenesis in Wistar Rats: An In silico, In vitro, and In vivo study [0.03%]
番木碱通过体内、体外及分子模拟研究对抗DMH致Wister大鼠 colorectalcancer的作用机制
Monu Kumar Kashyap,Akash Ved,Pranay Wal et al.
Monu Kumar Kashyap et al.
Objective: The objective of this study is to investigate the role of the aporphine alkaloid boldine as a potential inhibitor of specific protein targets involved in colorectal cancer, using in silico docking and molecular...
Syntheses and Identification of New Dithiophosphinic Acid Complexes and Their Potential as Photodynamic Agents in Cancer Therapy [0.03%]
新的二硫代磷酸复合物的合成、鉴定及其作为癌症治疗光动力剂的潜力
Kübra A Coşkun,Elif Bulat,Hamza Yılmaz et al.
Kübra A Coşkun et al.
Background: The photo-efficacy of oncological phototherapy for both internal and external tumors is encouraging. When light and photochemotherapeutic drugs are applied together, precise cancer targeting, minimal invasiven...
Vishakha A Patil,Kalyani R Thombre,Krishna Radheshyam Gupta et al.
Vishakha A Patil et al.
Currently, the main focus of anticancer drug development and research is to develop anticancer treatment strategies that are both less harmful and more effective. Flavones, a subclass of flavonoids, have shown great promise in the advanceme...
Exploring the Cholinesterase Inhibitory Potential of Azines Bearing a 4,4-bisdimethylaminobenzophenone Scaffold: An Experimental and Computational Approach [0.03%]
基于4,4-双二甲氨基苯并苯酮支架的偶氮化合物乙酰胆碱酯酶抑制活性的实验和计算研究
Ghulam Ahad,Aftab Alam,Ahmed A Elhenawy et al.
Ghulam Ahad et al.
Background: Acetyl and butyrylcholinesterase are significant enzymes involved in neurological diseases, and the development of more effective inhibitors is crucial for beneficial interference. ...
Identification of Potential FDA-Approved Inhibitors of SARS-CoV-2 Helicase Through a Multistep In silico Approach: A Promising Prospect for COVID-19 Treatment [0.03%]
通过多步计算机模拟鉴定SARS-CoV-2解旋酶潜在的FDA批准抑制剂：治疗COVID-19的一项有希望的前景
Ibrahim H Eissa,Eslam B Elkaeed,Alaa Elwan et al.
Ibrahim H Eissa et al.
Introduction: In this research aiming at combating COVID-19, we employed advanced computer-based methods to identify potential inhibitors of SARS-CoV-2 helicase from a pool of 3009 clinical and FDA-approved drugs. ...