In Vitro Evaluation of p-Toluenesulfonyl Hydrazones as Anti- Trypanosoma cruzi and Leishmanicidal Agents [0.03%]
作为抗查科尔森锥虫和利什曼原生动物剂的对甲苯磺酰腙的体外评价研究
Eya Caridad,Timoteo Delgado-Maldonado,Diana V Navarrete-Carriola et al.
Eya Caridad et al.
Introduction: Neglected tropical diseases (NTDs), such as Chagas disease (CD) and Cutaneous Leishmaniasis (CL), are significant global health concerns. The limited number of treatments and their severe adverse effects wor...
Discovery of Novel 1,3,4-oxadiazole-based Inhibitors Against Urease and Diabetes: Design, Synthesis, SAR, Biological, and Molecular Docking Screening [0.03%]
基于1,3,4-噁二唑的脲酶和糖尿病抑制剂的设计、合成、生物筛选及分子对接筛选
Sabeen Arshad,Aneela Maalik,Wajid Rehman et al.
Sabeen Arshad et al.
Introduction: Heterocyclic compounds bearing oxygen and nitrogen atoms are key pharmacophores in modern drug design. Among them, 1,3,4-oxadiazoles are notable for their diverse biological activities, including anti-inflam...
Recent Advances in the Biological Profiles of Fluorine-Containing Pyridine and its Derivatives: A Brief Overview [0.03%]
含氟吡啶及其衍生物的生物学谱新进展：概览
Abrar Hussain,Sayeda Sania Seher,Shahzaib Akhter et al.
Abrar Hussain et al.
Fluorine-containing pyridine derivatives have emerged as pivotal structures in modern drug discovery due to their unique physicochemical properties and diverse pharmacological activities. The incorporation of fluorine into pyridine-based sc...
Exploring Recent Advances in the Pharmacological Activities of Pyrazole Compounds: A Comprehensive Review [0.03%]
近吡唑化合物药理活性研究进展的全面综述
Kunal G Raut,Anuruddha R Chabukswar,Priyanka S Waghmare et al.
Kunal G Raut et al.
Pyrazole-based compounds have gained considerable attention in recent years due to their diverse and potent pharmacological properties. This review provides an up-to-date examination of the therapeutic potential of various substituted pyraz...
Recent Advances in Synthetic Pathways and Therapeutic Potential of Acridine and Acridone Derivatives [0.03%]
近年吖啶及吖啶酮衍生物合成途径及其治疗潜力的最新进展
Kalyani A Dalvi,Sarita S Pawar
Kalyani A Dalvi
Cancer, bacterial, parasitic, viral, and neurological diseases like Alzheimer's continue to pose serious health risks around the world. We need new therapeutic agents that are more targeted, effective, and safer. Because of their wide range...
Pluripotent Cinnamic Acid and Valproic Acid Hybrid Molecules Designed as Strong Anti-inflammatory and Anti-hyperlipidemic Compounds [0.03%]
作为强抗炎和抗高脂血症化合物的肉桂酸和丙戊酸杂化分子的设计
Panagiotis Theodosis-Nobelos,Eleni A Rekka
Panagiotis Theodosis-Nobelos
Introduction: Inflammation and oxidative stress are considered main pathophysiological factors for neuronal and cardiovascular diseases, also leading to the impairment of main cellular metabolic pathways. Promotion of hyp...
Design, Synthesis, Biological Evaluation, and In Silico Studies of Tetrazole Derivatives as Potential Cytotoxic Agents [0.03%]
设计、合成、生物评价及分子模拟研究新型四氮唑衍生物作为潜在的细胞毒剂
Mahalakshmi C S Parepalli,Rajitha Galla
Mahalakshmi C S Parepalli
Introduction: Despite significant progress in cancer treatment, the need for new anticancer agents remains critical. Current research efforts are directed toward discovering novel compounds that exhibit potent cytotoxic a...
Advances in Medicinal Chemistry of Fused and Substituted Piperazines: Unlocking their Potential as Anticancer Agents [0.03%]
融合和取代哌嗪类药物化学的研究进展：开发新型抗癌药物的潜力探索
Saumya Singh,Rajnish Kumar,Shrishti Tripathi et al.
Saumya Singh et al.
Cancer is an abnormal growth of normal cells and has become a global healthcare concern. The availability of safer anticancer drugs with exceptional selectivity for healthy cells and high efficacy against various forms of cancer remains a s...
Blueberries and Their Polyphenols: A Review of the Evidence and the Potential Impact on Inflammation, Oxidative Stress, Vascular and Cardiometabolic Function [0.03%]
关于蓝莓及其多酚的综述：证据及对炎症、氧化应激和血管功能与心血管代谢的影响
Shivangi Sharma
Shivangi Sharma
Blueberries contain a wide range of bioactive compounds, including polyphenols- plant-based chemicals known for their antioxidant and anti-inflammatory properties. Numerous in vitro and animal studies have suggested that these compounds may...
Unlocking the Multifunctional Therapeutic Potential of Herbacetin: A Flavone derived Scaffold [0.03%]
揭开学松素的多功能治疗潜力：一种黄酮衍生支架
Navin Kumar Tailor
Navin Kumar Tailor
Herbacetin (HBT), a naturally occurring flavone, exhibits broad therapeutic -- potential, including anti-cancer, anti-inflammatory, antioxidant, antimicrobial, neuroprotective, and anti-diabetic effects, by modulating key signaling pathways...