Unveiling the Therapeutic Potential of 8-Hydroxyquinoline: A Multi-Targeting Approach [0.03%]
8-羟基喹啉治疗潜力的揭示：多靶点策略
Riddhisiddhi Patel,Drashti Shah,Ashish Patel
Riddhisiddhi Patel
In recent years, extensive research has been conducted by medicinal and organic chemists on derivatives of 8-Hydroxyquinoline (8-HQ) due to their potential as therapeutic agents for a wide range of diseases and disorders. These derivatives ...
Hypolipidemic and Hepatoprotective Effects of 5-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)Pentanoic Acid (TDPPA) on Hyperlipidemic Mice [0.03%]
5-(4-(3-硫代-3h-1,2-二噻-5-基)苯氧基)戊酸(TDPPA)对高脂血症小鼠的降血脂和保肝作用
Ting Li,Manjun Liu,Qiuzhen Yuan et al.
Ting Li et al.
Introduction: Hyperlipidemia is a prevalent condition that accelerates the development of cardiovascular diseases. Traditional treatments targeting lipid regulation often have limitations, such as hepatotoxicity. This stu...
Virtual Screening of HBV Capsid Assembly Modulators with the Combination of Pharmacophore Modeling and Hydrogen Bond Constraints [0.03%]
基于药效团模型和氢键约束的HBV衣壳组装调节剂虚拟筛选研究
Hui Zhao,Yunwen Wang,Huihui Yan et al.
Hui Zhao et al.
Introduction: Hepatitis B virus (HBV) infection remains a significant public health challenge. Targeting HBV capsid assembly has the potential to achieve a functional cure for HBV infection, and the capsid assembly modula...
Stereoisomerism in Chemistry and Drug Development: Optical, Geometrical, and Conformational Isomers [0.03%]
化学和药物开发中的立体异构现象：光学异构体、几何异构体和构象异构体
Shivani Chawla,Rishikesh Gupta,Sudhanshu Kumar Jha et al.
Shivani Chawla et al.
Stereoisomerism in addition to conformational, geometrical, and optical isomerism, has considerable effects on the stability, reactivity, and functioning of molecules. Therefore, the objective of this article is to review the recent develop...
Dimitra Hadjipavlou-Litina
Dimitra Hadjipavlou-Litina
A Step Towards Development and Bio-evaluation of a Novel Radio-ligand 99mTc-CYX-DTPA Targeting Sigma 2 Receptors [0.03%]
新型放射配体99mtc-cyx-dtpa的作用机制及Sigma-2受体显像的初步研究
Ritika Chaudhary,Shubhra Chaturvedi,Divya Gautam et al.
Ritika Chaudhary et al.
Introduction: Development of theranostics agents targeted towards particular receptors can effectively help in the management of cancer. The overexpression of the sigma-2 receptor (S2R) in tumors establishes it as a promi...
In silico Study of Novel Tryptanthrin-Based Topoisomerase Inhibitors [0.03%]
基于试验证据的新型喜树碱衍生物拓扑异构酶抑制剂的计算机虚拟筛选及活性评价研究
Mukesh Kumar Kumawat,Kapil Kumar
Mukesh Kumar Kumawat
Background: Over the past ten years, a remarkable number of changes have occurred in the field of cancer drug research. Most anticancer drugs from the first generation work by breaking down DNA, preventing its production,...
De novo Drug Design and Repurposing to Suppress Liver Cancer via VEGF-R1 Mechanism: Comprehensive Molecular Docking, Molecular Dynamics Simulations and ADME Estimation [0.03%]
基于VEGF-R1机制的肝癌抑制药物从头设计与老药新用：全面分子对接、分子动力学模拟及ADME估算
Soykan Agar
Soykan Agar
Aim: The aim is to halt the progression of liver cancer (Hepatocellular carcinoma) by suppressing the VEGF-R1 receptor using Myricetin and its de novo-designed analogues. ...
Arylcarboxamide Derivatives as Promising HDAC8 Inhibitors: An Overview in Light of Structure-activity Relationship and Binding Mode of Interaction Analysis [0.03%]
基于结构活性关系和相互作用结合模式分析的有前景HDAC8抑制剂芳基羧胺衍生物研究综述
Suvankar Banerjee,Sandip Kumar Baidya,Tarun Jha et al.
Suvankar Banerjee et al.
HDAC8 is associated with several disease conditions as well as various cancers of several organs and hematological malignancies. To counter such pathophysiological and disease conditions, inhibition of HDAC8 may be a promising approach for ...
Unveiling the Anti-cancer Potential of Oxadiazole Derivatives: A Comprehensive Exploration of Structure-Activity Relationships and Chemico-Biological Insights [0.03%]
噁二唑衍生物的抗肿瘤潜力研究：结构活性关系及化学生物学见解的全面探索
Sai Satyaprakash Mishra,Ajeya Samanta,Abhik Paul et al.
Sai Satyaprakash Mishra et al.
Background: Oxadiazole derivatives have shown significant potential as anti-cancer agents with low μM potencies. Some examples of drugs in this class include Raltegravir, Zibotentan, Setileuton (MK-0633), Nesapidil, Fura...