Ligustrazine derivatives. Part 8: design, synthesis, and preliminary biological evaluation of novel Ligustrazinyl amides as cardiovascular agents [0.03%]
Ligustrazine衍生物。第8部分：新颖的Ligustrazinin酰胺作为心血管制剂的设计、合成和初步生物评价
Zhenyu Li,Fang Yu,Lei Cui et al.
Zhenyu Li et al.
A series of novel Ligustrazinyl amides was designed, synthesized and evaluated for their protective effect on the injured vascular endothelial cells. The preliminary results demonstrated that some compounds possessed more potent activities ...
Bioavailability of endomorphins and the blood-brain barrier--a review [0.03%]
内源性摩菲肽与血脑屏障的生物利用度--综述式研究
Renata Perlikowska,Anna Janecka
Renata Perlikowska
Opioid peptides have the potential to be pharmaceutical agents for the treatment of pain because they modulate nociceptive pathways at supraspinal, spinal and peripheral levels. Unfortunately, peptides are generally hydrophilic compounds an...
Antimicrobial, crown gall tumor inhibitory and cytotoxicity assays of N-[(1-methyl-1H-indole-3-yl)methylene]amines synthesized by an improved protocol [0.03%]
通过改进的方法合成的N-[(1-甲基-1H-吲哚-3-基)亚甲基]胺类化合物的抗菌、冠瘿瘤抑制及细胞毒性研究
Girija S Singh,Yasser M S A Al-kahraman,Disah Mpadi et al.
Girija S Singh et al.
The present paper reports an easy preparation of imines of N-methyl-1H-indole-3-carboxaldehyde by its condensation with alkyl and aromatic amines in ethanol without using any catalyst or dehydrating agent. The compounds have been screened f...
Microwave assisted synthesis and in vitro antimicrobial activities of fluorine containing 4-benzofuran-2-yl-6-phenyl-pyrimidin-2-ylamines [0.03%]
含氟4-苯并呋喃-2-基-6-苯基-嘧啶-2-胺的合成及其体外抗菌活性研究
Tejpal Singh Chundawat,Nutan Sharma,Sunita Bhagat
Tejpal Singh Chundawat
A series of new analogs fluorine containing heterocyclic system viz. 4-benzofuran-2-yl-6-phenyl-pyrimidin-2- ylamine has been synthesized and evaluated for in vitro antibacterial and antifungal activities. Microwave assisted Claisen-Schmidt...
Synthesis and antiproliferative assay of norcantharidin derivatives in cancer cells [0.03%]
胆衍安宁类似物的合成及其抗肿瘤细胞增殖活性检测
Guo Gang Tu,Jian Feng Zhan,Qiao Li Lv et al.
Guo Gang Tu et al.
Diels-Alder reaction between furan and maleic anhydride resulted in 5,6-dehydro norcantharidin, then norcantharidin was obtained by reduction. The substituted-carboxylic acid was condensed with N-aminothiourea in presence of phosphorus oxyc...
Self-organizing maps for the classification of gallic acylate polyphenols as HSV-1 inhibitors [0.03%]
自组织图分类棓酸茋类黄酮聚合酚作为HSV-1抑制剂
Xianxiu Qiu,Meigong Zhong,Yangfei Xiang et al.
Xianxiu Qiu et al.
Herpes simplex virus type 1 (HSV-1), a member of the Herpesviridae family, is a ubiquitous, contagious, hostadapted pathogen that causes a wide variety of disease states, such as herpes labialis ("cold sores") and encephalitis. Recently, du...
Synthesis, immunomodulation and cytotoxic effects of vanadium (IV) complexes [0.03%]
vanadium(IV)复合物的合成、免疫调节和细胞毒性效应
Uzma Ashiq,Rifat Ara Jamal,Mohammad Ahmed Mesaik et al.
Uzma Ashiq et al.
Vanadium is known to exhibit several bioactivities and shows potential as a pharmaceutical drug. The current studies were conducted with the goal of synthesizing a new generation of oxovanadium(IV) complexes, investigating their effects on ...
Synthesis and biological activities of 2,6-dihydroxy-4-isopentenyloxychalcone as an antimicrobial and anti-inflammatory compound [0.03%]
2,6-二羟基-4-异戊烯氧基查尔酮的合成及其抗菌和抗炎活性研究
Laetitia Bonifait,Lei Zhao,Jabrane Azelmat et al.
Laetitia Bonifait et al.
Chalcones are a group of plant-derived polyphenolic compounds possessing a wide variety of biological activities. The aim of this study was to synthesize 2,6-dihydroxy-4-isopentenyloxychalcone (1), a chalcone found in plants belonging to th...
Antifungal activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone derivatives [0.03%]
3-（杂芳基-2-亚甲基）硫唑烷酮衍生物的抗真菌活性
Gabriela H Marques,Alice Kunzler,Valéria D O Bareño et al.
Gabriela H Marques et al.
Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus la...
Synthesis and inhibitory effects of some novel 1,3-diarylprop-2-en-1-one analogues in Foxp3 expression: a novel class of anti-cancer candidates [0.03%]
一些新型1,3-二芳基丙-2-烯-1-酮类似物的合成及其对Foxp3表达抑制作用和抗肿瘤活性的研究
Mayank Kinger,Jeong Hoon Park,Min Goo Hur et al.
Mayank Kinger et al.
A series of novel analogues of 1,3-diarylprop-2-en-1-one (3a-m) were synthesized and evaluated for their inhibitory activity of FOX P3 gene expression and apoptosis in CD4(+)T cells that had been isolated from the spleen of 8 to 10 weeks ol...