Dan Wang,Ming-Tao Xia,Jia-Xin Yan et al.
Dan Wang et al.
Cyclin-Dependent Kinase (CDK) 12 is a member of the 20-membered CDK family (CDK1-20) and plays a vital role in regulating gene transcription, mRNA splicing, translation, cell cycle, and repair of DNA damage. CDK12 is an emerging therapeutic...
Ajit Manchare,Swapnali Parit,Mukta Lele et al.
Ajit Manchare et al.
The escalating prevalence of lifestyle and microbial diseases poses a significant threat to human well-being, necessitating the discovery and development of novel drugs with distinct modes of action. Addressing this challenge involves emplo...
Natural Compounds from Alhagi maurorum as Potential HCC and HepG2 Inhibitors: An Integrated Study using Pharmacophore Development, Molecular Docking, MD Simulation, and DFT Approaches [0.03%]
基于阿尔哈吉毛蕊苔中的天然化合物作为潜在的肝癌和HepG2抑制剂：一种结合药效团生成、分子对接、MD模拟和DFT方法的研究
Aniqa Moveed,Shagufta Parveen,Nusrat Shafiq et al.
Aniqa Moveed et al.
Background: The rise in the frequency of liver cancer all over the world makes it a prominent area of research in the discovery of new drugs or repurposing of existing drugs. ...
High-prediction QSAR Modeling Study Based on the Efficacy of a Novel 6-hydroxybenzothiazole-2-carboxamide Targeted Monoamine Oxidase B in the Treatment of Neurodegenerative Diseases [0.03%]
基于新型6-羟基苯并噻唑-2-羧酰胺单胺氧化酶B靶向性效力的高预测QSAR建模研究
Dong Xie,Zhibiao Cai,Junxiang Mao et al.
Dong Xie et al.
Background: Neurodegenerative diseases are a group of disorders characterized by progressive neuronal degeneration and death, of which Alzheimer's disease and Parkinson's disease are the most common. These diseases are cl...
Recent Advancements in the Synthetic Chemistry of Oxazole Derivatives and their Significant Medicinal Applications [0.03%]
噁唑衍生物合成化学的最新进展及其重要的医药应用
Pratibha Yadav,Kamal Shah
Pratibha Yadav
The five-membered oxazole motif heterocyclic aromatic ring has been gaining considerable attention due to its bioisosterism property and unusually wide range of desired biological properties. Thus, it is a perfect pre-built platform for the...
Promising Anticancer Activity of Pyrazole Compounds against Glioblastoma Multiforme: Their Synthesis, In vitro, and Molecular Docking Studies [0.03%]
吡唑化合物抗胶质母细胞瘤的抗癌活性研究：合成、体外及分子对接研究
Kemal Alp Nalcı,Cihat Mete,Zeynep Demir et al.
Kemal Alp Nalcı et al.
Background: Glioblastoma Multiforme (GBM), a highly aggressive and prevalent brain cancer with a higher incidence in males, has limited treatment success due to drug resistance, inadequate targeting and penetration of can...
An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive [0.03%]
一种集成的计算方法识别抗帕金森氏病植物来源生物活性分子中的C-Abl激酶抑制剂
Haruna Isiyaku Umar,Zainab Ashimiyu-Abdusalam,Neeraj Kumar et al.
Haruna Isiyaku Umar et al.
Background: Oxidative stress is strongly linked to neurodegeneration through the activation of c-Abl kinase, which arrests α-synuclein proteolysis by interacting with parkin interacting substrate (PARIS) and aminoacyl tR...
Identification of Natural Terpenoid Compounds as Potential Inhibitors of Nucleoprotein of Influenza A Virus using in silico Approach: ADMET, Molecular Docking, and Molecular Dynamic Simulation [0.03%]
基于计算方法鉴定天然倍半萜化合物为流感病毒核蛋白抑制剂：ADMET，分子对接及分子动力学模拟研究
Md Saddam Hossain,Md Mosahaq Ali,Prithbay Raj et al.
Md Saddam Hossain et al.
Background: We continue to struggle with the prevention and treatment of the influenza virus. The 2009 swine flu pandemic, caused by the H1N1 strain of influenza A, resulted in numerous fatalities. The threat of influenza...
Pyrazoline Derivatives: Exploring the Synthesis and Development of New Ligands for Anti-Cancer Therapy [0.03%]
吡唑啉衍生物：抗癌症治疗新配体的合成与开发研究
Renu Sharma,Salahuddin,Avijit Mazumder et al.
Renu Sharma et al.
Pyrazoline is a 5-membered ring that has two adjacent nitrogen. It has gained advanced attention from medical and organic chemists due to very low cytotoxic activities. It is applicable and more applied in research fields and has various ph...
Isoindoline-1,3-dione Derivatives as Prototypes for Anticonvulsant Drug Discovery [0.03%]
异吲哚-1,3-二酮衍生物作为抗惊厥药物发现的原型分子
Rafael Consolin Chelucci,Richard Chiquetto,Diego Eidy Chiba et al.
Rafael Consolin Chelucci et al.
Introduction: Epilepsy encompasses numerous syndromes characterized by spontaneous, intermittent, and abnormal electrical activity in the brain. Affecting about 1-2% of the population, it is estimated that approximately 3...