Andreia Marques,Susen Müller
Andreia Marques
Significant progress has been made in past decades in our understanding of the basic mechanisms underlying autoimmune diseases. Nevertheless, many questions remain unanswered, in particular regarding the mechanisms at very early stages of t...
Karsten Seeger
Karsten Seeger
Metabolomics is a recently emerging member of the "omics" technologies. It aims at detecting and quantifying all detectable small molecules, the so-called metabolites, present in a biological sample. Because of the lower number of metabolit...
Biologics as treatment for systemic lupus: great efforts, sobering results, new challenges [0.03%]
生物制剂治疗系统性红斑狼疮的尝试、反思和展望
Johann O Schröder,Rainald A Zeuner
Johann O Schröder
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by specific organ manifestations and the production of autoantibodies to nuclear antigens. SLE can induce severe organ damage and carries the risk of fatal outcome. D...
Update on clinical, pathophysiological and therapeutic aspects in ANCA-associated vasculitides [0.03%]
抗中性粒细胞胞浆抗体相关性血管炎的临床、病理生理和治疗进展的更新
Peter Lamprecht,Julia Holle,Wolfgang L Gross
Peter Lamprecht
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) comprise the most common group of primary systemic vasculitides and include Wegener;s granulomatosis (WG), microscopic polyangiitis (MPA), Churg-Strauss syndrome ...
Manfred Kunz
Manfred Kunz
Psoriasis is a chronic inflammatory skin disease with a significant number of patients suffering from additional joint involvement and other co-morbidities. The precise pathomechanisms of this disease are still unknown. But based on recent ...
M Kunz
M Kunz
The use of iontophoresis in the administration of nicotine and new non-nicotine drugs through the skin for smoking cessation [0.03%]
经皮烟碱和新非烟碱类药物的电穿孔法给药在戒烟中的应用
José Juan Escobar-Chávez,Virginia Merino,Miriam López-Cervantes et al.
José Juan Escobar-Chávez et al.
Cigarette smoking is the primary cause of lung cancer, cardiovascular diseases, reproductive disorders and delayed wound healing all over the world; as such, the goals of smoking cessation are both to reduce health risks and to improve qual...
Johan L F Kock,Chantel W Swart,Desmond M Ncango et al.
Johan L F Kock et al.
Previous studies show that acetylsalicylic acid (aspirin) at low concentrations affects yeast sexual structure development in a similar fashion than oxygen depletion. This is ascribed to its anti-mitochondrial action. In this study, we repo...
Systemic delivery of curcumin: 21st century solutions for an ancient conundrum [0.03%]
姜黄素的全身给药：21世纪的解决方案与古难题
Savita Bisht,Anirban Maitra
Savita Bisht
Curcumin, a polyphenolic compound derived from the dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, anti-oxidant, anti-proliferative and anti-angiogenic activities. Accumulating experimental evide...
Future therapeutic directions; new medications and insulin delivery in a changing world for effective diabetes management [0.03%]
未来治疗方向；新药与胰岛素输送在糖尿病管理中的应用展望
Pankaj Modi
Pankaj Modi
Insulin remains a key to the management of diabetes. The early addition of insulin to oral therapy in type-2 patients is recognized as an effective option that can help improve glycemic control and reduces the complications and contribute t...