Discovering Active Chemotherapeutic Agents for Sexually Transmitted Diseases to Inhibit Pathogenic HPV-16-E6 Protein [0.03%]
用于抑制病原体HPV-16-E6蛋白的性传播疾病化疗活性药物的研究发现
Vemula Vani,Manikandan Alagumuthu,Sanjay Prasad et al.
Vemula Vani et al.
Background: One of the most prevalent sexually transmitted diseases (STDs) is infection with the human papillomavirus (HPV). The current treatment methods comprise employing chemotherapeutic medications or doing surgery t...
Recent Development, Applications, and Patents of Artificial Intelligence in Drug Design and Development [0.03%]
人工智能在药物设计与研发中的 recent进展、应用和专利布局分析
Prashant Kumar,Alpana Mahor,Roopam Tomar
Prashant Kumar
Drug design and development are crucial areas of study for chemists and pharmaceutical companies. Nevertheless, the significant expenses, lengthy process, inaccurate delivery, and limited effectiveness present obstacles and barriers that af...
Molecular Modeling Studies and Synthesis of Isocryptolepine Derivatives as Antimalarial Using Docking, CoMFA, CoMSIA, and HQSAR [0.03%]
用于抗疟疾的异隐品碱衍生物的分子对接、CoMFA、CoMSIA和HQSAR研究及合成
Shourya Pratap,Abhilasha Mittal,Sambit Kumar Parida
Shourya Pratap
Background: Our research highlights the synthesis of newer antimalarial compounds using molecular modeling studies. Objective: The stud...
Fatemeh Forouzanfar,Zahra Meshkat
Fatemeh Forouzanfar
Berberine is an isoquinoline alkaloid with strong pharmacological activity such as analgesic, antioxidant, neuroprotective, antivirus, anti-inflammatory, anti-seizure, anti-obesity, and hypolipidemic effects. Accumulated evidence indicates ...
Renal Impairment Caused by Statins in Rats Can Be Restored by Thymoquinone [0.03%]
鼠类他莫喹通过辅酶Q10介导的途径逆转由他汀类药物所致的肾损害
Sherif S Hassan,Charity Thomann,Shaimaa Amin et al.
Sherif S Hassan et al.
Background: Atorvastatin (ATO) is an HMG-CoA reductase inhibitor used to lower blood cholesterol, but it causes renal injury in high doses. Thymoquinone (TQ), is a natural antioxidant that has been shown to protect the ki...
Peptic Ulcer Disease: A Comprehensive Review on Conventional Therapy and Herbal Treatment [0.03%]
消化性溃疡病：常规治疗与草药疗法的全面综述
Vijay Kumar,Vrinda Goel,Sakshi Bajaj et al.
Vijay Kumar et al.
Still today, peptic ulcer disease (PUD) is a major digestive illness that affects millions of people around the world every year. This study looks at both traditional and herbal ways of treating PUD, focusing on how they work, how well they...
Delineating CYP2C19-Mediated Interactions: Network Pharmacology Investigation of Ilaprazole and Clopidogrel versus Conventional Proton Pump Inhibitors [0.03%]
基于网络药理学的艾拉普拉唑与氯吡格雷联合用药相对于常规质子泵抑制剂的作用机制研究
Priyadharshini Ananthathandavan,Damodharan Narayanasamy
Priyadharshini Ananthathandavan
Background: Clopidogrel, an antiplatelet drug commonly used in cardiovascular disease, is metabolized by the liver mainly through CYP2C19. Concomitant use of Proton pump inhibitors along with clopidogrel may affect the po...
Importance of Computer-Aided Drug Design in Modern Pharmaceutical Research [0.03%]
计算机辅助药物设计在现代药学研究中的重要性
Uma Agarwal,Rajiv Kumar Tonk,Swati Paliwal
Uma Agarwal
Background: Computer-Aided Drug Design (CADD) approaches are essential in the drug discovery and development process. Both academic institutions and pharmaceutical and biotechnology corporations utilize them to enhance th...
Potential of Nanoparticle Based Antimicrobial Drug Repurposing to Efficiently Target Alzheimer's: A Concise Update on Evidence-based Research and Challenges Ahead [0.03%]
基于纳米颗粒的抗菌药物再定位有效靶向阿尔茨海默病的潜力：有关循证研究和未来挑战的简要更新
Biswabhusan Biswal,Bhabani Sankar Satapathy,Abhishek Mishra et al.
Biswabhusan Biswal et al.
Repurposing of drugs through nanocarriers (NCs) based platforms has been a recent trend in drug delivery research. Various routine drugs are now being repurposed to treat challenging neurodegenerative disorders including Alzheimer disease (...
Shikha Sharma,Utkarsh Sharma,Neha Dangi et al.
Shikha Sharma et al.
An efficient immune system in the host body plays a crucial role in the preservation of normal biological and immune reactions and processes, as well as the intrinsic environment. This is because the immune system is responsible for fightin...