Christophe Van de Wiele
Christophe Van de Wiele
In this review paper, available data on radioembolization of unresectable hepatocellular carcinoma (HCC) using commercially available radiopharmaceuticals, respectively (131)I-Lipiodol, Therasphere (glass-microspheres) and SIRspheres (resin...
Frank I Lin,Andrei Iagaru
Frank I Lin
Radioimmunotherapy relies on the principles of immunotherapy, but expands the cytotoxic effects of the antibody by complexing it with a radiation-emitting particle. If we consider radioimmunotherapy as a step beyond immunotherapy of cancer,...
Targeting the nucleus: an overview of Auger-electron radionuclide therapy [0.03%]
靶向细胞核：Auger电子放射性治疗概览
Bart Cornelissen,Katherine A Vallis
Bart Cornelissen
The review presented here lays out the present state of the art in the field of radionuclide therapies specifically targeted against the nucleus of cancer cells, focussing on the use of Auger-electron-emitters. Nuclear localisation of radio...
Emerging technologies for the study of drug metabolism and pharmacokinetics [0.03%]
用于药物代谢和药代动力学研究的新技术
Yunsheng Hsieh
Yunsheng Hsieh
Integration of physicochemical and pharmacokinetic parameters in lead optimization: a physiological pharmacokinetic model based approach [0.03%]
基于生理药代动力学模型的理化和药代参数在先导化合物优化中的整合应用
Biju Benjamin,Tarani Kanta Barman,Tridib Chaira et al.
Biju Benjamin et al.
There have been major strides in the development of novel ways of investigating drug like properties of new chemical entities (NCE) in the last three decades. Identification of ideal properties of a clinical candidate that would give a clin...
Alison E M Vickers,Robyn L Fisher,John R Sinclair
Alison E M Vickers
Glutathione (GSH) levels are modulated in human liver slices to evaluate if drug induced liver injury is enhanced by a poor liver GSH status. Liver slice GSH levels were decreased by: 1) BSO (L-buthionine-S-sulfoximine) to inhibit GSH synth...
The in silico prediction of human-specific metabolites from hepatotoxic drugs [0.03%]
基于计算预测人体特异代谢产物中的肝毒性药物
Luis G Valerio Jr,Anthony Long
Luis G Valerio Jr
In this study we employed the use of the Meteor computational software program to perform predictions in silico on 17 hepatotoxic drugs for determining human-specific drug metabolites. Congruence of the in silico predictions from a qualitat...
Hepatocytes as a tool in drug metabolism, transport and safety evaluations in drug discovery [0.03%]
肝细胞在药物代谢、转运及安全性评估中的作用——从靶点到临床二期试验
Jasminder Sahi,Susan Grepper,Cornelia Smith
Jasminder Sahi
The liver is the primary site of metabolism for most drugs. Its major roles include detoxification of the systemic and portal blood, and production and secretion of critical blood and biliary components. A number of liver-derived in vitro s...
Emerging in vitro tools to evaluate cytochrome P450 and transporter-mediated drug-drug interactions [0.03%]
体外评估药物-药物相互作用的新兴工具——细胞色素P450和转运蛋白介导的药物-药物相互作用
Chuang Lu,Mingxiang Liao,Lawrence Cohen et al.
Chuang Lu et al.
Drug-drug interactions comprise a significant cause of morbidity and mortality worldwide as they may lead to adverse clinical events, result in decrease/inactivation of the therapeutic effect of a drug, may enhance drug toxicity and indirec...
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for drug development [0.03%]
亲水作用色谱-质谱联用在药物研发中的应用
Yunsheng Hsieh
Yunsheng Hsieh
Hydrophilic interaction chromatography (HILIC) offers a difference in selectivity as compared to traditional normal phase and reversed-phase liquid chromatography and therefore has great potential for the separation of a variety of pharmace...