Xinyu Rong,Yinghua Xie,Xiaomei Hao et al.
Xinyu Rong et al.
Drug-loaded polymeric nanocapsules have exhibited potential applications in the field of drug delivery systems in recent years. This article entails the biodegradable polymers generally used for preparing nanocapsules, which include both na...
Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective [0.03%]
基于物理化学原理的凝集素免疫型荧光纳球用于结直肠癌识别研究
Shinji Sakuma,Shinji Yamashita,Ken-ichiro Hiwatari et al.
Shinji Sakuma et al.
The goal of this research is to develop an imaging agent that enables real-time and accurate diagnosis of small-sized colorectal cancer. Since colorectal cancer initially develops in the mucous membrane of the large intestine, a nonabsorbab...
Quercetin-phospholipid complex: an amorphous pharmaceutical system in herbal drug delivery [0.03%]
檞皮素-磷脂复合物：一种草药药物传递系统的无定形药物体系
Devendra Singh,Mohan S Rawat,Ajay Semalty et al.
Devendra Singh et al.
Development of amphiphilic drug-lipid complexes is a potential approach for improving therapeutic efficacy of the drugs by increasing solubility, release profile and oral bioavailability. Quercetin (3, 3', 4', 5, 7-pentahydroxyflavone), a p...
Annmarie Mollaghan,Jarmila Vinsova,Ales Imramovsky et al.
Annmarie Mollaghan et al.
This study examined the antibacterial properties of nineteen benzoxazole, isoniazid, ethionamide and salicylanilide derivatives against Staphylococcus aureus (S. aureus). It was found that three salicylanilide-derived compounds demonstrated...
Comparative Study
Current drug discovery technologies. 2012 Mar;9(1):39-47. DOI:10.2174/157016312799304525 2012
Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway [0.03%]
胰岛素通过激活PI3K/Akt途径降低结肠癌细胞系HT29的疗效
Jiezhong Chen,Andrew Katsifis,Changhua Hu et al.
Jiezhong Chen et al.
Obesity has been associated with both the carcinogenesis and poor prognosis of colon cancer, one of the leading causes of cancer-related death. Increased blood levels of insulin in obese subjects have been demonstrated to play a key role in...
Evaluation of mutual information, genetic algorithm and SVR for feature selection in QSAR regression [0.03%]
用于QSAR回归的互信息、遗传算法和SVR在特征选择中的评估
Jianwen Fang,David Tai
Jianwen Fang
Feature selection has become increasingly important for quantitative structure-activity relationship (QSAR) studies. In the present article, we evaluate three state-of-the-art feature selection algorithms, namely mutual information (MI), ge...
Comparative Study
Current drug discovery technologies. 2011 Jun;8(2):107-11. DOI:10.2174/157016311795563839 2011
Kenneth Lundstrom
Kenneth Lundstrom
The key regular functions of microRNAs (miRNAs) were only discovered a few years ago, when it became evident that miRNAs play important roles in gene regulation. Today, more than 700 miRNAs have been identified from the human genome. Becaus...
Hydrogels based on interpenetrating network of chitosan and polyvinyl pyrrolidone for pH-sensitive delivery of repaglinide [0.03%]
基于壳聚糖和聚乙烯吡咯烷酮互穿网络的用于瑞格列奈pH敏感传递的水凝胶
Subhash S Vaghani,Madhabhai M Patel
Subhash S Vaghani
The aim of this study was to develop a pH-sensitive chitosan/polyvinyl pyrrolidone (PVP) based controlled drug release system for repaglinide. The hydrogels were synthesised by crosslinking chitosan and PVP blend with glutaraldehyde to form...
Current advances in delivery of biotherapeutics across the blood-brain barrier [0.03%]
穿越血脑屏障递送生物治疗药物的最新进展
Manoj Rajadhyaksha,Tracey Boyden,Jennifer Liras et al.
Manoj Rajadhyaksha et al.
Significant efforts through genomic approaches have been dedicated toward the identification of novel protein-protein interactions as promising therapeutic targets for indications such as Alzheimer's disease, Parkinson's disease and neurops...
Soo-Hyun Kim,Hyo-Jeong Kuh,Crispin R Dass
Soo-Hyun Kim
Despite significant improvements in ways to treat cancer, numerous patients still die from this disease. One of the reasons for this inability to cure cancer is the lack of ability of drugs to penetrate target cells properly. While studies ...