Pharmacological Insights on USFDA-Approved Novel Drug Therapies in the Year 2023 [0.03%]
2023年美国食品药品监督管理局批准的新型药物治疗的药理学见解
Parveen Kumar Goyal,Vipasha Sharma,Kavita Sangwan
Parveen Kumar Goyal
Objective: This manuscript, aimed to prepare a scientific report, underscores the pharma-cotherapeutic aspects, including therapeutic indications, mechanisms of therapeutic action, pharma-cokinetics, adverse reactions, sa...
Breaking Boundaries in Cancer Therapy: Harnessing Chromothripsis- Induced Mutations for Targeted BCL2 Protein Destabilization [0.03%]
突破癌症治疗的界限：利用染色体碎裂诱导的突变进行靶向BCL2蛋白失稳化疗法
Sergey Shityakov,Michael Nosonovsky,Ekaterina Skorb et al.
Sergey Shityakov et al.
Chromothripsis, a phenomenon of massive genomic rearrangements, introduces extensive mutations in critical genes, affecting cell survival and apoptosis. Among these genes, the BCL2 (B-cell lymphoma 2) gene, which plays a crucial antiapoptot...
Therapeutic Potential of Flavonoids in Diabetes Mellitus Management: Molecular Insights and the Future Directions for Drug Design [0.03%]
黄酮类化合物在糖尿病治疗中的潜力：分子机制洞察及药物设计的未来方向
Ritika Chauhan,Srinivasa Rao Sirasanagandla,Vishnu Priya Veeraraghavan et al.
Ritika Chauhan et al.
Diabetes mellitus (DM) is a prevalent metabolic disorder with a rapidly rising global inci-dence, presenting a significant burden to healthcare systems worldwide. Flavonoids, a class of natu-rally occurring polyphenolic compounds, are well-...
Exploring Herbal Remedies as Adjunctive Therapies in Managing Inflammation and Rheumatoid Arthritis [0.03%]
探究草药作为辅助疗法在炎症和类风湿性关节炎管理中的作用
Vijay Raghav,Swati Arya,Rubina Bhutani et al.
Vijay Raghav et al.
Habitual inflammation is defined as the persistent activation of the body's susceptible sys-tem in response to harmful events. This ongoing inflammatory process can sometimes harm normal organs & tissues. Crucially, chronic inflammation has...
Challenges and Countermeasures for Ensuring Health and Drug Stability During Long-Term Space Missions [0.03%]
保障长期太空任务中健康和药物稳定性的挑战与对策
Santhosh Kumar Venugopalan,Sneha Sri R,Harikrishnan N et al.
Santhosh Kumar Venugopalan et al.
Microgravity, space radiation, and pharmaceutical degradation are all long-term chal-lenges for astronauts traveling through space. Radiation exposure is one of the greatest health risks to astronauts in space. Associated with these conditi...
Cannabigerol and Cannabinoid Receptors in Major Depressive Disorder: Network Pharmacology, Molecular Docking, and In-vivo Analysis [0.03%]
大麻叶素和大麻素受体在抑郁症中的作用：网络药理学、分子对接及体内分析
Abhishek Sharma,Rahul Singh,Shivkant Sharma et al.
Abhishek Sharma et al.
Introduction: Cannabigerol (CBG), being one of the non-psychotropic phyto-cannabinoid, has been labelled and recognized to be antioxidant and neuroprotective; it may conceivably hold depression-relieving activity. Consequ...
Bioactive Compounds as a Potential Inhibitor of Biofilm Production: An In silico Study to Identify Natural Hindrance Resources [0.03%]
生物活性化合物作为潜在的抑制生物膜产生的物质：一项关于识别天然阻碍资源的分子模拟研究
Jai Gupta,Avi Gupta,Debasmita Bhattacharya et al.
Jai Gupta et al.
Background: Biofilm formation by microorganisms, specifically bacteria, threatens vari-ous fields, including biomedicine and the environment. The development of biofilms has associations with increased resistance to antim...
Bioactive Flavonoids and Phenolic Acids of Petroselinum Crispum as a Potential Inhibitor of α-amylase: An in silico Evaluation [0.03%]
欧芹(Petroselinum crispum)中的黄酮类和酚酸化合物作为α-淀粉酶抑制剂的潜力：基于计算机的评估
Ishita Biswas,Trishanjan Biswas,Debanjan Mitra
Ishita Biswas
Background: Type II diabetes mellitus is treated as one of the detrimental diseases and the drugs used for its treatment often lead to several side effects. Therefore, herbal medication of plant origin with lesser offshoo...
Techniques and Strategies for Engineering Vaccine Adjuvants: A Comprehensive Review [0.03%]
疫苗佐剂的工程技巧和策略：全面综述
Suman Sharma,Rajani Chauhan,Qumar Negar et al.
Suman Sharma et al.
Vaccines are biological products used to prevent diseases and ailments caused by viruses, bacteria, and fungi. Vaccine adjuvants increase the potency of the vaccine. The vaccine adjuvants like gold nanoparticle, silver nanoparticle, Lentina...
Design of Potent Telomerase Inhibitors Using Ligand-based Approaches and Molecular Dynamics Simulations Studies [0.03%]
基于配体的潜在端粒酶抑制剂的设计及分子动力学模拟研究
Shalini Bajaj,Manikanta Murahari,Mayur Yc
Shalini Bajaj
Background: Telomerase is a well-recognised and a promising target for cancer therapy. In this study, we selected ligand-based approaches to design telomerase inhibitors for the develop-ment of potent anticancer agents fo...