Advancements in Drug Discovery Techniques for Cancer Treatment: Clinical Progress and Future Directions [0.03%]
癌症治疗的药物发现技术进展：临床进步和未来方向
Rachana Choudhary,Neetu Das,Bhuneshwari Nayak et al.
Rachana Choudhary et al.
Cancer has emerged as one of the most pressing public health issues in the world and has led to extensive research in novel treatment techniques. Among them, cancer treatment strategies targeting disease-specific pathways have become a focu...
Theranostic Applications of Microrobots: Integrating Diagnostics and Precision Drug Delivery [0.03%]
微机器人诊疗应用：诊断与精准药物输送的集成
Pushpender Sharma,Chirag Jain,Shikha Baghel Chauhan et al.
Pushpender Sharma et al.
A game-changing strategy in precision medicine is theranostics, which is the combination of diagnostics and treatments on one platform. Microrobots have drawn a lot of interest as promising agents in theranostic applications because of thei...
Recent Advancement in Drug Delivery Systems for the Treatment of Rheumatoid Arthritis [0.03%]
用于治疗类风湿性关节炎的给药系统最新进展
Neelesh Singh,Rajesh Choudhary
Neelesh Singh
Rheumatoid arthritis (RA) is an autoimmune disease that features chronic inflammation of the joints, destruction of the synovial tissue, and progressive disability. Traditional treatments with disease-modifying antirheumatic drugs (DMARDs),...
Anjali,Sumitra Nain
Anjali
Nowadays, a wide range of aromatic heterocyclic compounds are employed as therapeutics. Among these, pyrimidine is a well-known nucleus with two nitrogen atoms at the first and third positions of six-membered rings, with the chemical formul...
Advances in Periodontal Therapy: A Comprehensive Review of In-Situ Forming Dental Cements for Effective Pocket Filling [0.03%]
牙周治疗进展：用于有效袋装的原位形成性牙膏综述
Anuj Kumar,Anurag Verma,Phool Chandra et al.
Anuj Kumar et al.
Fifty percent of people worldwide suffer from periodontitis, a chronic inflammation of the soft tissue that surrounds the teeth. Effective filling of dental pockets is paramount for successful treatment outcomes in periodontal therapy. This...
Formulation, Optimization and Design of Capecitabine Nanosuspension to Enhance the Anti-Gastric Cancer Efficacy using Box-Behnken Quality-based Design Study [0.03%]
采用Box-Behnken质量设计法优化和设计卡培他滨纳米混悬液以增强抗胃癌疗效
Mayank Kumar Khede,Bhabani Shankar Nayak,Harekrishna Roy et al.
Mayank Kumar Khede et al.
Background: Capecitabine is an anticancer antimetabolite of fluorouracil that inhibits cell proliferation and impairs DNA repair in cancer cells. It is given specifically to treat metastatic breast, gastric and colorectal...
Computational Investigation of Phytochemicals Targeting Isocitrate Lyase to Inhibit Mycobacterium tuberculosis [0.03%]
计算研究植物化学物质靶向异柠檬酸裂解酶以抑制结核分枝杆菌
Mandeep Chouhan,Mukesh Kumar,Richa Mishra et al.
Mandeep Chouhan et al.
Introduction: The global burden of tuberculosis (TB) remains a major concern for society that is worsening day by day with the emergence of drug-resistant TB as well as risks associated with latent TB. Isocitrate lyase (I...
In Silico Prediction of Human Intestinal Permeability (Caco-2) using QSPR Modelling for Efficient Drug Discovery [0.03%]
基于QSAR建模的药物跨胃肠上皮吸收的计算机预测方法研究
Aayush Chowdhury,Sayantani Garai,Dipro Mukherjee et al.
Aayush Chowdhury et al.
Background: The quantitative structure-property relationship (QSPR) modelling can be helpful in the in-silico prediction and pre-determination of the drug permeability values of a large number of compounds through human i...
Unlocking the Potential of Alginate Polymers: A Review of Recent Advances in Physicochemical Modulation for Versatile Biomaterials [0.03%]
藻酸盐聚合物的物理化学调控研究进展：多功能生物材料的构建解锁
Shiom Mane,Poournima Sankpal,Sachinkumar Patil et al.
Shiom Mane et al.
Alginate, a naturally occurring polysaccharide, exhibits immense potential for diverse ap-plications due to its ability to undergo chemical modifications and blend with other constituents. These modifications enable the creation of alginate...
Exploring Novel Oxazole Derivatives for Cancer Therapy: Design, Synthesis, and Mechanistic Insights [0.03%]
用于癌症治疗的新款噁唑衍生物的探索：设计、合成及机制见解
Mushtaque A S Shaikh,Pawan Jadhav,Trupti Jadhav et al.
Mushtaque A S Shaikh et al.
Background: The search for potent anticancer agents has accelerated the evaluation of a wide variety of pharmacological scaffolds, including oxazole derivatives. Although they are currently underexplored, they are promisi...