Design, In Silico Molecular Docking, and ADMET Prediction of Amide Derivatives of Chalcone Nucleus as EGFR Inhibitors for the Treatment of Cancer [0.03%]
作为癌症治疗的EGFR抑制剂的查尔酮核酰胺衍生物的设计、分子对接和ADMET预测
Shital M Patil,Vrushali Randive,Indrani Mahadik et al.
Shital M Patil et al.
Background: Cancer is a devastating disease. Many studies have shown that the primary causes of the aggressive and resistant types of cancer are the overexpression of receptors and growth factors, activation of oncogenes,...
A Review on the Role of Phytoconstituents Chrysin on the Protective Effect on Liver and Kidney [0.03%]
查尔辛对肝脏和肾脏保护作用的植物成分的作用综述
Debika Sarmah,Rupa Sengupta
Debika Sarmah
Background: The chance of contracting significant diseases increases due to an unhealthy and contemporary lifestyle. Chrysin is a flavonoid of the flavone class in numerous plants, including Passiflora and Pelargonium. Ch...
Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF-α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats [0.03%]
姜黄、牛轧和芝麻联合提取物的毒理学评估及对链脲佐菌素诱导的糖尿病大鼠抗糖尿病作用及其对TNF-α、TGF-β和氧化应激的调节作用
Shivam,Asheesh Kumar Gupta
Shivam
Background: Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum are used as traditional medicines to treat diabetes mellitus. A collection of metabolic illnesses known as diabetes mellitus (DM) involves chroni...
Modeling the Antiviral Activity of Ginkgo biloba Polyphenols against Variola: In Silico Exploration of Inhibitory Candidates for Var TMPK and Hss TMPK Enzymes [0.03%]
基于计算机的抗天花病毒药物筛选与活性分子发现研究
Hamdani Sarra,Bouchentouf Salim,Allali Hocine
Hamdani Sarra
Background: The aim of this study is to use modeling methods to estimate the antiviral activity of natural molecules extracted from Ginkgo biloba for the treatment of variola which is a zoonotic disease posing a growing t...
In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets [0.03%]
计算筛选一些植物化学活性成分以寻找针对SARS-CoV-2靶点的有前景的抑制剂
V Alagarsamy,V Raja Solomon,S Murugesan et al.
V Alagarsamy et al.
Background: There are very few small-molecule drug candidates developed against SARS-CoV-2 that have been revealed since the epidemic began in November 2019. The typical medicinal chemistry discovery approach requires mor...
Design, Docking, Characterisation, and Synthesis of Pyrimidine Derivatives for Antidepressant Activity [0.03%]
设计、对接、表征和合成具有抗抑郁活性的嘧啶衍生物
Ashwini Jadhav,Sunil G Shingade,Prachita Gauns Dessai et al.
Ashwini Jadhav et al.
Background: According to the report, in 2022, the prevalence rate of depression in India was 4.50%, and the cases stood at 56,675,969. The development of antidepressant agents has reduced the number of depressant and suic...
Nutritional Profile, GC-MS Analysis and In-silico Anti-diabetic Phytocompounds Candidature of Jatropha gossypifolia Leaf Extracts [0.03%]
Jatropha gossypifolia叶提取物的营养谱系，GC-MS分析及反向模拟抗糖尿病候选药理成分研究
Olasunkanmi Kayode Awote,Rahmon Ilesanmi Kanmodi,Success Chidera Ebube et al.
Olasunkanmi Kayode Awote et al.
Background: Diabetes mellitus (DM) is a metabolic disorder known to impair many physiological functions via reactive oxygen species (ROS). Aldose reductase, sorbitol dehydrogenase, dipeptidyl peptidase IV, α-amylase and ...
Samah Hamed Almurisi,Ayah Mohammed,Farah Qassem et al.
Samah Hamed Almurisi et al.
Aim: This study aimed to formulate and characterize aceclofenac buccal film formulations made of different polymers and evaluate the effects of polymer type on buccal film properties. ...
Inhibitory Effects of Carvacrol on Biofilm Formation in Colistin Heteroresistant Acinetobacter baumannii Clinical Isolates [0.03%]
肉桂酚抑制黏菌素低度耐药的鲍曼不动杆菌临床分离株生物被膜形成的作用机制研究
Iraj Pakzad,Fatemeh Yarkarami,Behrooz Sadeghi Kalani et al.
Iraj Pakzad et al.
Background: The ability of bacteria to form biofilm is an essential strategy for creating stable infections. This issue is more critical in Acinetobacter bauamannii as a hospital pathogen. Today, the control of biofilm fo...
Computational Studies and Synthesis of New Heterocyclics as CNS Agents [0.03%]
作为CNS活性剂的新杂环化合物的计算研究和合成
Pooja Saini,Sushil Kumar
Pooja Saini
Aim: This research work aimed to design and synthesize some new molecules of phenothiazine. The work's emphasis was on forming new phenothiazines in two series, 1-(10H-phenothiazin-10-yl)-2-((4-(1-(phenylimino)ethyl)pheny...