In-silico, in-vitro and in-vivo Biological Activities of Flavonoids for the Management of Type 2 Diabetes [0.03%]
黄酮类化合物的体外、离体及体内生物活性对2型糖尿病的控制管理研究
Jyoshna Rani Dash,Biswakanth Kar,Gurudutta Pattnaik
Jyoshna Rani Dash
In spite of the fact that many medicinal plants have been truly utilized for the management of diabetes all through the world, very few of them have been reported scientifically. Recently, a diverse variety of animal models have been establ...
The Evolving Landscape of Pharmaceutical Regulation: Striking a Balance between Innovation and Safety [0.03%]
药品监管的演变格局：在创新与安全之间寻求平衡
Debanjan Mukherjee,Sarjana Raikwar
Debanjan Mukherjee
Design, Synthesis, Characterisation, and Evaluation of Substituted Quinolin-2-one Derivatives as Possible Anti-lung Cancer Agents [0.03%]
取代喹啉-2-酮衍生物的设计，合成，特征描述及作为潜在抗肺癌药物的评价
Riya Swar,Prachita Gauns Dessai,Shivalingrao MamleDesai et al.
Riya Swar et al.
Background: According to 2022, the estimated number of cancer cases in India was found to be 1,461,427. Lung cancers are the leading cause of death among Indian males. Research on cancer has been conducted to develop bett...
Biological Activities of Zinc Oxide Nanoparticles Green Synthesized Using the Aqueous Extract of Dracocephalum kotschyi Boiss [0.03%]
利用龙胆紫蜂草水提取液绿色合成的氧化锌纳米粒子的生物活性
Foroogh Mirzania,Iraj Salimikia,Javad Ghasemian Yadegari et al.
Foroogh Mirzania et al.
Background: Dracocephalum kotschyi Boiss. is known as a native medicinal plant of Iran. Objective: In this study, aqueous extract of D....
An Eco-friendly Strategy for the Synthesis of Spiro-benzimidazoquinazolinone and Spiro-benzothiazoloquinazolinone Derivatives using β-cyclodextrin as a Supramolecular Catalyst [0.03%]
以β-环糊精为超分子催化剂合成螺-苯并咪唑喹唑啉酮和螺-苯并噻唑喹唑啉酮衍生物的环保策略
Jyoti Baranwal,Swastika Singh,Smriti Kushwaha et al.
Jyoti Baranwal et al.
Background: Cyclodextrins selectively bind with reactants and facilitate chemical reactions through supramolecular catalysis, similar to the mechanisms employed by enzymes. In this paper, β-cyclodextrin was used as a sup...
Articulate Chemotherapeutic Strategies for the Development of Effective Drugs against a Fatal Disease, Visceral Leishmaniasis [0.03%]
开发有效治疗致命疾病——内脏利什曼病的化学治疗策略药物
Awanish Kumar
Awanish Kumar
Visceral Leishmaniasis (VL) control relies mainly on chemotherapy in the absence of no effective vaccines. However, available anti-VL drugs are limited in number, having toxicity issues, adverse reactions, low efficacy, and resistance obser...
Effects of Kojic Acid-mediated Sonodynamic Therapy as a Matrix Metalloprotease-9 Inhibitor against Oral Squamous Cell Carcinoma: A Bioinformatics Screening and in vitro Analysis [0.03%]
基于生物信息学筛选的曲酸介导聚焦超声联合抑制基质金属蛋白酶-9治疗舌鳞状细胞癌的研究
Maryam Pourhajibagher,Mojgan Alaeddini,Shahroo Etemad-Moghadam et al.
Maryam Pourhajibagher et al.
Background: Oral squamous cell carcinoma (OSCC) is a type of cancer that is responsible for a significant amount of morbidity and mortality worldwide. Researchers are searching for promising therapeutic methods to manage ...
Kapil Kumar,Harshita Gandhi
Kapil Kumar
Breast cancer is a severe global health problem, and early detection, accurate diagnosis, and personalized treatment is the key to improving patient outcomes. Artificial intelligence (AI) and machine learning (ML) have emerged as promising ...
In Search of Novel SGLT2 Inhibitors by High-throughput Virtual Screening [0.03%]
基于高通量虚拟筛选的新SGLT2抑制剂的探究
Abhijit Debnath,Shalini Sharma,Rupa Mazumder et al.
Abhijit Debnath et al.
Background: Type 2 diabetes mellitus constitutes approximately 90% of all reported forms of diabetes mellitus. Insulin resistance characterizes this manifestation of diabetes. The prevalence of this condition is commonly ...
Docking of T6361 Analogues as Potential Inhibitors of E.coli MurA Followed by ADME-Toxicity Study [0.03%]
T6361类似物与大肠杆菌MurA的对接及药物代谢动力学-毒性研究
Ilham Boulhissa,Hanane Boucherit,Abdelouahab Chikhi et al.
Ilham Boulhissa et al.
Background: Developing more potent antibacterial agents is one of the most important tasks of scientists in the health field due to the problem of antibiotic resistance. Among the antibiotic targets, we mention MurA (UDP-...